Gene Page: C3orf18
Summary ?
| GeneID | 51161 |
| Symbol | C3orf18 |
| Synonyms | G20 |
| Description | chromosome 3 open reading frame 18 |
| Reference | HGNC:HGNC:24837|Ensembl:ENSG00000088543|HPRD:16654|Vega:OTTHUMG00000156854 |
| Gene type | protein-coding |
| Map location | 3p21.3 |
| Pascal p-value | 0.518 |
| Fetal beta | -0.528 |
| DMG | 2 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 3 |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 3 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg14035045 | 3 | 50606289 | HEMK1;C3orf18 | 2.002E-4 | 0.297 | 0.035 | DMG:Wockner_2014 |
| cg24075738 | 3 | 50605156 | C3orf18 | 5.574E-4 | -0.29 | 0.049 | DMG:Wockner_2014 |
| cg03703325 | 3 | 50606864 | C3orf18 | 5.78E-10 | -0.015 | 9.07E-7 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | C3orf18 | 51161 | 0 | trans | ||
| rs3845734 | chr2 | 171125572 | C3orf18 | 51161 | 0 | trans | ||
| rs7584986 | chr2 | 184111432 | C3orf18 | 51161 | 0.13 | trans | ||
| rs17762315 | chr5 | 76807576 | C3orf18 | 51161 | 3.824E-6 | trans | ||
| rs17111984 | chr14 | 95881425 | C3orf18 | 51161 | 0.11 | trans | ||
| rs16955618 | chr15 | 29937543 | C3orf18 | 51161 | 3.821E-8 | trans | ||
| rs17540498 | chr15 | 93800424 | C3orf18 | 51161 | 0.19 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| YAUCH HEDGEHOG SIGNALING PARACRINE DN | 264 | 159 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO CSF2RB AND IL4 UP | 338 | 225 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF UP | 418 | 282 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN | 245 | 150 | All SZGR 2.0 genes in this pathway |
| VANTVEER BREAST CANCER ESR1 UP | 167 | 99 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |