SZGR2

Summary ?

GeneID	53615
Symbol	MBD3
Synonyms	-
Description	methyl-CpG binding domain protein 3
Reference	MIM:603573\|HGNC:HGNC:6918\|Ensembl:ENSG00000071655\|HPRD:04653\|Vega:OTTHUMG00000180081
Gene type	protein-coding
Map location	19p13.3
Pascal p-value	0.089
Sherlock p-value	0.363
Fetal beta	-0.133
eGene	Myers' cis & trans
Support	Ascano FMRP targets Chromatin Remodeling Genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs4491879	chr3	189373908	MBD3	53615	0.16	trans
rs17542473	chr4	111182451	MBD3	53615	0.2	trans
rs2143256	chr20	9664538	MBD3	53615	0.09	trans
rs6039548	chr20	9666092	MBD3	53615	0.14	trans
rs6056802		0	MBD3	53615	0.09	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AURKA	AIK \| ARK1 \| AURA \| AURORA2 \| BTAK \| MGC34538 \| STK15 \| STK6 \| STK7	aurora kinase A	-	HPRD,BioGRID	12354758
BCL6	BCL5 \| BCL6A \| LAZ3 \| ZBTB27 \| ZNF51	B-cell CLL/lymphoma 6	BCL6 interacts with MBD3.	BIND	15454082
CHD4	DKFZp686E06161 \| Mi-2b \| Mi2-BETA	chromodomain helicase DNA binding protein 4	Affinity Capture-Western	BioGRID	12354758
DNMT1	AIM \| CXXC9 \| DNMT \| FLJ16293 \| MCMT \| MGC104992	DNA (cytosine-5-)-methyltransferase 1	-	HPRD	10947852
GATAD2A	FLJ20085 \| FLJ21017 \| p66alpha	GATA zinc finger domain containing 2A	-	HPRD,BioGRID	12183469
GATAD2B	FLJ37346 \| KIAA1150 \| MGC138257 \| MGC138285 \| P66beta \| RP11-216N14.6	GATA zinc finger domain containing 2B	-	HPRD	12183469
GATAD2B	FLJ37346 \| KIAA1150 \| MGC138257 \| MGC138285 \| P66beta \| RP11-216N14.6	GATA zinc finger domain containing 2B	-	HPRD,BioGRID	11756549 \|12183469
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	-	HPRD,BioGRID	12124384
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	MBD3 interacts with HDAC1.	BIND	12124384
HDAC2	RPD3 \| YAF1	histone deacetylase 2	Affinity Capture-Western	BioGRID	12354758
MBD2	DKFZp586O0821 \| DMTase \| NY-CO-41	methyl-CpG binding domain protein 2	-	HPRD	10947852
MBD2	DKFZp586O0821 \| DMTase \| NY-CO-41	methyl-CpG binding domain protein 2	Reconstituted Complex Two-hybrid	BioGRID	10444591 \|15456747
MBD3	-	methyl-CpG binding domain protein 3	Two-hybrid	BioGRID	15456747
MBD3L1	MBD3L \| MGC138263 \| MGC138269	methyl-CpG binding domain protein 3-like 1	-	HPRD,BioGRID	15456747
MTA2	DKFZp686F2281 \| MTA1L1 \| PID	metastasis associated 1 family, member 2	MBD3 interacts with MTA2.	BIND	12124384
MTA2	DKFZp686F2281 \| MTA1L1 \| PID	metastasis associated 1 family, member 2	-	HPRD,BioGRID	12124384
RBBP4	NURF55 \| RBAP48	retinoblastoma binding protein 4	-	HPRD,BioGRID	10444591
RBBP7	MGC138867 \| MGC138868 \| RbAp46	retinoblastoma binding protein 7	-	HPRD,BioGRID	10444591
SPEN	KIAA0929 \| MINT \| RP1-134O19.1 \| SHARP	spen homolog, transcriptional regulator (Drosophila)	-	HPRD	11331609

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
BIOCARTA MTA3 PATHWAY	19	10	All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY	66	50	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN	335	193	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP	479	299	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES	230	137	All SZGR 2.0 genes in this pathway
MOOTHA VOXPHOS	87	51	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP	157	105	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS REQUIRE MYC	210	123	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D DN	64	35	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN	274	165	All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002	429	260	All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA	447	277	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES	462	273	All SZGR 2.0 genes in this pathway

Gene Page: MBD3