Gene Page: PNMT

Summary ?
GeneID5409
SymbolPNMT
SynonymsPENT|PNMTase
Descriptionphenylethanolamine N-methyltransferase
ReferenceMIM:171190|HGNC:HGNC:9160|Ensembl:ENSG00000141744|HPRD:07176|Vega:OTTHUMG00000133209
Gene typeprotein-coding
Map location17q12
Pascal p-value0.004
Sherlock p-value0.557
Fetal beta-0.375
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16823058chr2170317903PNMT54090.08trans
rs10230373chr7147962729PNMT54090.15trans
rs7062071chrX17724830PNMT54090.08trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
POLR2I0.910.85
AP000350.60.860.76
MRPL230.850.78
SSNA10.840.74
LAGE30.840.73
RNASEH2C0.830.73
NDUFB70.830.84
NDUFA30.830.71
NDUFA110.820.75
C11orf830.820.76
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
UPF2-0.41-0.41
MYSM1-0.41-0.42
GOLGA4-0.41-0.43
KIF5B-0.40-0.43
BDP1-0.40-0.41
BTBD8-0.40-0.44
VPS13C-0.39-0.39
FMNL2-0.39-0.43
KIF16B-0.39-0.40
MON2-0.39-0.39

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG TYROSINE METABOLISM 4230All SZGR 2.0 genes in this pathway
BIOCARTA NEUROTRANSMITTERS PATHWAY 65All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200136All SZGR 2.0 genes in this pathway
REACTOME AMINE DERIVED HORMONES 1512All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 8 77All SZGR 2.0 genes in this pathway
WANG HCP PROSTATE CANCER 11169All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON 13378All SZGR 2.0 genes in this pathway
ROSS AML OF FAB M7 TYPE 6844All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157105All SZGR 2.0 genes in this pathway
HOEGERKORP CD44 TARGETS TEMPORAL UP 138All SZGR 2.0 genes in this pathway
SMID BREAST CANCER ERBB2 UP 14783All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 13 3020All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 18197All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
STAMBOLSKY RESPONSE TO VITAMIN D3 UP 8448All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418245All SZGR 2.0 genes in this pathway