Gene Page: SEPT4

Summary ?
GeneID5414
SymbolSEPT4
SynonymsARTS|BRADEION|CE5B3|H5|MART|PNUTL2|SEP4|hCDCREL-2|hucep-7
Descriptionseptin 4
ReferenceMIM:603696|HGNC:HGNC:9165|Ensembl:ENSG00000108387|HPRD:04738|Vega:OTTHUMG00000179243
Gene typeprotein-coding
Map location17q22
Pascal p-value6.625E-4
Sherlock p-value0.522
eGenePutamen basal ganglia
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs347042611756353429SEPT4ENSG00000108387.101.54396E-60.02264750gtex_brain_putamen_basal
rs1173693541756371332SEPT4ENSG00000108387.103.39794E-60.02246847gtex_brain_putamen_basal
rs757515341756377870SEPT4ENSG00000108387.103.73691E-60.02240309gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RARRES30.800.79
SDS0.790.73
MGST10.790.78
AGXT2L10.790.75
MT1X0.780.75
IL17RB0.780.62
NQO10.780.78
SCRG10.750.77
SAT10.750.73
TAPBPL0.750.73
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MKL1-0.51-0.69
SPTAN1-0.51-0.72
UBE2O-0.51-0.65
GTF2F1-0.51-0.72
MYO18A-0.51-0.63
USP7-0.51-0.68
KIF3C-0.51-0.72
HERC1-0.51-0.69
RUSC2-0.51-0.69
NEURL4-0.50-0.72

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003924GTPase activityTAS9889007 
GO:0005525GTP bindingIEA-
GO:0005198structural molecule activityTAS9889007 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000910cytokinesisTAS9889007 
GO:0007049cell cycleIEA-
GO:0042981regulation of apoptosisNAS11146656 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005634nucleusNAS11146656 
GO:0005737cytoplasmIEA-
GO:0005739mitochondrionNAS11146656 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
CEBALLOS TARGETS OF TP53 AND MYC DN 3831All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357212All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG UP 7850All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207145All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240152All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262186All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS UP 4731All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373196All SZGR 2.0 genes in this pathway
LEIN ASTROCYTE MARKERS 4235All SZGR 2.0 genes in this pathway
LEIN OLIGODENDROCYTE MARKERS 7453All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway
MATZUK SPERMATOZOA 11477All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL UP 185112All SZGR 2.0 genes in this pathway
SEKI INFLAMMATORY RESPONSE LPS DN 2316All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293203All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G6 UP 6543All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP 176110All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253192All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 11 10368All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 UP 13485All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242146All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321200All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
SERVITJA ISLET HNF1A TARGETS UP 163111All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-2141151221A,m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG