Gene Page: DEF8
Summary ?
| GeneID | 54849 |
| Symbol | DEF8 |
| Synonyms | - |
| Description | differentially expressed in FDCP 8 homolog (mouse) |
| Reference | HGNC:HGNC:25969|Ensembl:ENSG00000140995|HPRD:07882|Vega:OTTHUMG00000138989 |
| Gene type | protein-coding |
| Map location | 16q24.3 |
| Pascal p-value | 0.029 |
| Sherlock p-value | 0.744 |
| eGene | Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7195043 | chr16 | 90020860 | DEF8 | 54849 | 0.08 | cis | ||
| rs8063761 | chr16 | 90027625 | DEF8 | 54849 | 0.15 | cis | ||
| rs17178299 | chr16 | 90103658 | DEF8 | 54849 | 0.13 | cis |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| XRCC6 | 0.92 | 0.93 |
| SF3A3 | 0.91 | 0.91 |
| MKI67IP | 0.91 | 0.93 |
| CPSF3 | 0.91 | 0.93 |
| VPS45 | 0.90 | 0.90 |
| DNTTIP2 | 0.90 | 0.91 |
| UTP11L | 0.90 | 0.89 |
| PLRG1 | 0.90 | 0.90 |
| TAF7 | 0.90 | 0.92 |
| SFRS3 | 0.90 | 0.92 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.78 | -0.81 |
| AF347015.33 | -0.78 | -0.83 |
| AF347015.8 | -0.77 | -0.81 |
| MT-CYB | -0.77 | -0.81 |
| AF347015.27 | -0.76 | -0.80 |
| AF347015.2 | -0.75 | -0.81 |
| AF347015.31 | -0.75 | -0.80 |
| AF347015.15 | -0.75 | -0.81 |
| AF347015.26 | -0.72 | -0.78 |
| AF347015.9 | -0.72 | -0.80 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ZHOU INFLAMMATORY RESPONSE LIVE DN | 384 | 220 | All SZGR 2.0 genes in this pathway |
| TIEN INTESTINE PROBIOTICS 24HR UP | 557 | 331 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| ROYLANCE BREAST CANCER 16Q COPY NUMBER UP | 63 | 44 | All SZGR 2.0 genes in this pathway |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 16Q24 AMPLICON | 53 | 38 | All SZGR 2.0 genes in this pathway |
| WANG SMARCE1 TARGETS DN | 371 | 218 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS STEM CELL | 254 | 164 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | All SZGR 2.0 genes in this pathway |
| GRADE COLON AND RECTAL CANCER UP | 285 | 167 | All SZGR 2.0 genes in this pathway |
| VANTVEER BREAST CANCER ESR1 DN | 240 | 153 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |