Gene Page: NECAP2
Summary ?
| GeneID | 55707 |
| Symbol | NECAP2 |
| Synonyms | - |
| Description | NECAP endocytosis associated 2 |
| Reference | MIM:611624|HGNC:HGNC:25528|Ensembl:ENSG00000157191|HPRD:07674|Vega:OTTHUMG00000002313 |
| Gene type | protein-coding |
| Map location | 1p36.13 |
| Pascal p-value | 0.022 |
| Sherlock p-value | 0.734 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7033592 | chr9 | 38119899 | NECAP2 | 55707 | 0.17 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PLEKHH1 | 0.93 | 0.85 |
| NIPAL4 | 0.93 | 0.71 |
| GLDN | 0.92 | 0.76 |
| NPC1 | 0.92 | 0.78 |
| MYO1D | 0.92 | 0.80 |
| PDE8A | 0.92 | 0.85 |
| SLC31A2 | 0.92 | 0.79 |
| USP54 | 0.92 | 0.79 |
| ERBB3 | 0.92 | 0.72 |
| SHROOM4 | 0.92 | 0.82 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RPL35 | -0.48 | -0.65 |
| RPL36 | -0.46 | -0.64 |
| RPL12 | -0.45 | -0.57 |
| SCNM1 | -0.45 | -0.50 |
| RPL27 | -0.45 | -0.62 |
| TBC1D10A | -0.45 | -0.41 |
| BCL7C | -0.45 | -0.52 |
| RPS9 | -0.44 | -0.60 |
| RPSA | -0.44 | -0.51 |
| C9orf46 | -0.44 | -0.51 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS DN | 848 | 527 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL CIS | 128 | 77 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL CIS | 65 | 38 | All SZGR 2.0 genes in this pathway |
| REN ALVEOLAR RHABDOMYOSARCOMA DN | 408 | 274 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | All SZGR 2.0 genes in this pathway |
| CHNG MULTIPLE MYELOMA HYPERPLOID DN | 28 | 19 | All SZGR 2.0 genes in this pathway |
| MOOTHA PGC | 420 | 269 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS UP | 221 | 135 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 3 DN | 42 | 24 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| KRIEG HYPOXIA VIA KDM3A | 53 | 34 | All SZGR 2.0 genes in this pathway |
| PHONG TNF RESPONSE NOT VIA P38 | 337 | 236 | All SZGR 2.0 genes in this pathway |