SZGR2

Summary ?

GeneID	5573
Symbol	PRKAR1A
Synonyms	ACRDYS1\|ADOHR\|CAR\|CNC\|CNC1\|PKR1\|PPNAD1\|PRKAR1\|TSE1
Description	protein kinase cAMP-dependent type I regulatory subunit alpha
Reference	MIM:188830\|HGNC:HGNC:9388\|Ensembl:ENSG00000108946\|HPRD:01786\|Vega:OTTHUMG00000180128
Gene type	protein-coding
Map location	17q24.2
Pascal p-value	0.163
Sherlock p-value	0.299
Fetal beta	-1.349
Support	CANABINOID DOPAMINE INTRACELLULAR SIGNAL TRANSDUCTION SEROTONIN G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ADRM1	0.91	0.89
POLR2E	0.90	0.89
GPS1	0.90	0.89
TOMM40	0.90	0.90
THAP4	0.89	0.87
TRAP1	0.89	0.88
FAM69B	0.89	0.90
IDH3G	0.88	0.86
MRPS2	0.88	0.88
TCF25	0.88	0.85

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.73	-0.73
AF347015.8	-0.71	-0.73
AF347015.33	-0.71	-0.74
MT-CO2	-0.71	-0.71
AF347015.27	-0.71	-0.75
MT-CYB	-0.70	-0.73
AF347015.21	-0.69	-0.72
AF347015.2	-0.68	-0.71
AF347015.15	-0.67	-0.71
AF347015.26	-0.64	-0.68

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKAP1	AKAP \| AKAP121 \| AKAP149 \| AKAP84 \| D-AKAP1 \| MGC1807 \| PRKA1 \| SAKAP84	A kinase (PRKA) anchor protein 1	-	HPRD	10764601 \|12634056\|12634056
AKAP1	AKAP \| AKAP121 \| AKAP149 \| AKAP84 \| D-AKAP1 \| MGC1807 \| PRKA1 \| SAKAP84	A kinase (PRKA) anchor protein 1	-	HPRD,BioGRID	9065479 \|12634056\|10764601 \|12634056\|12634056
AKAP10	D-AKAP2 \| MGC9414 \| PRKA10	A kinase (PRKA) anchor protein 10	-	HPRD,BioGRID	9326583
AKAP11	AKAP220 \| DKFZp781I12161 \| FLJ11304 \| KIAA0629 \| PRKA11	A kinase (PRKA) anchor protein 11	-	HPRD,BioGRID	10864471
AKAP4	AKAP82 \| FSC1 \| HI \| hAKAP82 \| p82	A kinase (PRKA) anchor protein 4	-	HPRD,BioGRID	9852104
AKAP7	AKAP18	A kinase (PRKA) anchor protein 7	-	HPRD	12804576
ARFGEF1	ARFGEP1 \| BIG1 \| D730028O18Rik \| DKFZP434L057 \| P200	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	Affinity Capture-Western	BioGRID	12571360
ARFGEF2	BIG2 \| FLJ23723 \| dJ1164I10.1	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	12571360
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	9050991
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	9050991
MCRS1	ICP22BP \| INO80Q \| MCRS2 \| MSP58 \| P78	microspherule protein 1	Affinity Capture-MS	BioGRID	17353931
MGC13057	-	hypothetical protein MGC13057	Two-hybrid	BioGRID	16189514
MYO7A	DFNA11 \| DFNB2 \| MYOVIIA \| MYU7A \| NSRD2 \| USH1B	myosin VIIA	Affinity Capture-Western Two-hybrid	BioGRID	10889203
NUAK1	ARK5 \| KIAA0537	NUAK family, SNF1-like kinase, 1	Affinity Capture-MS	BioGRID	17353931
PLEKHF2	FLJ13187 \| PHAFIN2 \| ZFYVE18	pleckstrin homology domain containing, family F (with FYVE domain) member 2	Two-hybrid	BioGRID	16189514
PRKACA	MGC102831 \| MGC48865 \| PKACA	protein kinase, cAMP-dependent, catalytic, alpha	Affinity Capture-MS	BioGRID	17353931
PRKAR1A	CAR \| CNC \| CNC1 \| DKFZp779L0468 \| MGC17251 \| PKR1 \| PPNAD1 \| PRKAR1 \| TSE1	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	Affinity Capture-Western Two-hybrid	BioGRID	12634056
PRKAR1B	PRKAR1	protein kinase, cAMP-dependent, regulatory, type I, beta	-	HPRD	12634056
PRKAR1B	PRKAR1	protein kinase, cAMP-dependent, regulatory, type I, beta	-	HPRD,BioGRID	8407966 \|12634056
PRKX	PKX1	protein kinase, X-linked	Reconstituted Complex	BioGRID	10026146
PYCARD	ASC \| CARD5 \| MGC10332 \| TMS \| TMS-1 \| TMS1	PYD and CARD domain containing	Two-hybrid	BioGRID	16189514
TUSC4	NPR2L \| NPRL2	tumor suppressor candidate 4	Affinity Capture-MS	BioGRID	17353931
UBE2M	UBC-RS2 \| UBC12 \| hUbc12	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	Affinity Capture-MS	BioGRID	17353931

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG APOPTOSIS	88	62	All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY	137	103	All SZGR 2.0 genes in this pathway
BIOCARTA NO1 PATHWAY	33	24	All SZGR 2.0 genes in this pathway
BIOCARTA CSK PATHWAY	24	20	All SZGR 2.0 genes in this pathway
BIOCARTA AGPCR PATHWAY	13	12	All SZGR 2.0 genes in this pathway
BIOCARTA CFTR PATHWAY	12	11	All SZGR 2.0 genes in this pathway
BIOCARTA GATA3 PATHWAY	16	15	All SZGR 2.0 genes in this pathway
BIOCARTA MPR PATHWAY	34	28	All SZGR 2.0 genes in this pathway
BIOCARTA MCALPAIN PATHWAY	25	16	All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1R PATHWAY	23	20	All SZGR 2.0 genes in this pathway
BIOCARTA VIP PATHWAY	29	26	All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY	56	45	All SZGR 2.0 genes in this pathway
BIOCARTA NOS1 PATHWAY	24	21	All SZGR 2.0 genes in this pathway
BIOCARTA PLCE PATHWAY	12	10	All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY	42	35	All SZGR 2.0 genes in this pathway
BIOCARTA BAD PATHWAY	26	23	All SZGR 2.0 genes in this pathway
BIOCARTA CK1 PATHWAY	17	17	All SZGR 2.0 genes in this pathway
BIOCARTA DREAM PATHWAY	14	13	All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY	37	31	All SZGR 2.0 genes in this pathway
BIOCARTA SHH PATHWAY	16	15	All SZGR 2.0 genes in this pathway
BIOCARTA STATHMIN PATHWAY	19	17	All SZGR 2.0 genes in this pathway
BIOCARTA CREB PATHWAY	27	25	All SZGR 2.0 genes in this pathway
BIOCARTA CARM1 PATHWAY	13	11	All SZGR 2.0 genes in this pathway
PID INTEGRIN A4B1 PATHWAY	33	24	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME DAG AND IP3 SIGNALING	32	25	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM	120	84	All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING	78	56	All SZGR 2.0 genes in this pathway
REACTOME CA DEPENDENT EVENTS	30	23	All SZGR 2.0 genes in this pathway
REACTOME DARPP 32 EVENTS	25	20	All SZGR 2.0 genes in this pathway
REACTOME PLC BETA MEDIATED EVENTS	43	32	All SZGR 2.0 genes in this pathway
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	18	14	All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES	413	270	All SZGR 2.0 genes in this pathway
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	34	23	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	43	28	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION	93	65	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE	54	40	All SZGR 2.0 genes in this pathway
REACTOME AQUAPORIN MEDIATED TRANSPORT	51	34	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	44	30	All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	132	101	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN	634	384	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED UP	112	71	All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP	372	227	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN	406	230	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP	175	108	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP	185	126	All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN	199	124	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN	537	339	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 UP	64	46	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B	392	251	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL	330	215	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
XU AKT1 TARGETS 6HR	27	18	All SZGR 2.0 genes in this pathway
SIMBULAN UV RESPONSE IMMORTALIZED DN	31	26	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN	81	51	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON	335	181	All SZGR 2.0 genes in this pathway
PARK HSC VS MULTIPOTENT PROGENITORS UP	19	14	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP	151	100	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
VISALA RESPONSE TO HEAT SHOCK AND AGING UP	15	10	All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP	198	132	All SZGR 2.0 genes in this pathway
MMS MOUSE LYMPH HIGH 4HRS UP	36	20	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP	123	75	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING	510	309	All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP	126	92	All SZGR 2.0 genes in this pathway
MATZUK SPERMATOZOA	114	77	All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP	198	128	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP	188	121	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP	91	59	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP	90	58	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway

Gene Page: PRKAR1A