Gene Page: PRKAR2B

Summary ?
GeneID5577
SymbolPRKAR2B
SynonymsPRKAR2|RII-BETA
Descriptionprotein kinase cAMP-dependent type II regulatory subunit beta
ReferenceMIM:176912|HGNC:HGNC:9392|Ensembl:ENSG00000005249|HPRD:01486|Vega:OTTHUMG00000137418
Gene typeprotein-coding
Map location7q22
Pascal p-value0.199
Sherlock p-value0.857
Fetal beta1.357
eGeneMyers' cis & trans
Meta
SupportCANABINOID
DOPAMINE
INTRACELLULAR SIGNAL TRANSDUCTION
SEROTONIN
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6949961chr7106850754PRKAR2B55770.16cis
rs17429118chr7106964051PRKAR2B55770.14cis
rs10994209chr1061877705PRKAR2B55770.16trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ARHGEF180.880.90
ZNF5920.870.88
MYBBP1A0.870.89
MUM10.870.87
GAK0.870.88
PPM1F0.870.87
NACAD0.860.87
INTS10.860.88
KIAA04270.860.89
FLCN0.850.87
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.70-0.74
AF347015.31-0.70-0.68
C1orf54-0.66-0.70
MT-CO2-0.64-0.65
CLEC2B-0.63-0.68
GNG11-0.62-0.64
MT-CYB-0.62-0.62
AF347015.27-0.62-0.63
HIGD1B-0.62-0.61
AF347015.8-0.62-0.63

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG APOPTOSIS 8862All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137103All SZGR 2.0 genes in this pathway
BIOCARTA NO1 PATHWAY 3324All SZGR 2.0 genes in this pathway
BIOCARTA CSK PATHWAY 2420All SZGR 2.0 genes in this pathway
BIOCARTA AKAP95 PATHWAY 129All SZGR 2.0 genes in this pathway
BIOCARTA AGPCR PATHWAY 1312All SZGR 2.0 genes in this pathway
BIOCARTA CFTR PATHWAY 1211All SZGR 2.0 genes in this pathway
BIOCARTA GATA3 PATHWAY 1615All SZGR 2.0 genes in this pathway
BIOCARTA MPR PATHWAY 3428All SZGR 2.0 genes in this pathway
BIOCARTA MCALPAIN PATHWAY 2516All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY 5843All SZGR 2.0 genes in this pathway
BIOCARTA IGF1R PATHWAY 2320All SZGR 2.0 genes in this pathway
BIOCARTA VIP PATHWAY 2926All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY 5645All SZGR 2.0 genes in this pathway
BIOCARTA NOS1 PATHWAY 2421All SZGR 2.0 genes in this pathway
BIOCARTA PLCE PATHWAY 1210All SZGR 2.0 genes in this pathway
BIOCARTA AKAPCENTROSOME PATHWAY 1514All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY 4235All SZGR 2.0 genes in this pathway
BIOCARTA BAD PATHWAY 2623All SZGR 2.0 genes in this pathway
BIOCARTA CK1 PATHWAY 1717All SZGR 2.0 genes in this pathway
BIOCARTA DREAM PATHWAY 1413All SZGR 2.0 genes in this pathway
BIOCARTA AKAP13 PATHWAY 1211All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY 3731All SZGR 2.0 genes in this pathway
BIOCARTA SHH PATHWAY 1615All SZGR 2.0 genes in this pathway
BIOCARTA STATHMIN PATHWAY 1917All SZGR 2.0 genes in this pathway
BIOCARTA CREB PATHWAY 2725All SZGR 2.0 genes in this pathway
BIOCARTA CARM1 PATHWAY 1311All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME DAG AND IP3 SIGNALING 3225All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2 10178All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER 10980All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137105All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE 12788All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM 12084All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325185All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 7856All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 6643All SZGR 2.0 genes in this pathway
REACTOME CA DEPENDENT EVENTS 3023All SZGR 2.0 genes in this pathway
REACTOME DARPP 32 EVENTS 2520All SZGR 2.0 genes in this pathway
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES 5938All SZGR 2.0 genes in this pathway
REACTOME PLC BETA MEDIATED EVENTS 4332All SZGR 2.0 genes in this pathway
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB 1814All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION 3423All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 12293All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 9576All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 4328All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION 9365All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 10074All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE 5440All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES 8150All SZGR 2.0 genes in this pathway
REACTOME AQUAPORIN MEDIATED TRANSPORT 5134All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 4430All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 132101All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR 11280All SZGR 2.0 genes in this pathway
LU TUMOR VASCULATURE DN 136All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE DN 8453All SZGR 2.0 genes in this pathway
DAVICIONI PAX FOXO1 SIGNATURE IN ARMS UP 5938All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP 332228All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255177All SZGR 2.0 genes in this pathway
DAVICIONI RHABDOMYOSARCOMA PAX FOXO1 FUSION UP 6437All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408247All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
LIU CMYB TARGETS UP 165106All SZGR 2.0 genes in this pathway
LIU VMYB TARGETS UP 12778All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN UP 184125All SZGR 2.0 genes in this pathway
GRABARCZYK BCL11B TARGETS UP 8140All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 15791All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194122All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP 175108All SZGR 2.0 genes in this pathway
HUMMEL BURKITTS LYMPHOMA UP 4327All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL QUIESCENT UP 8745All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP 5733All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP 181101All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS UP 14984All SZGR 2.0 genes in this pathway
BEGUM TARGETS OF PAX3 FOXO1 FUSION UP 6045All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326213All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL 330217All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514319All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203134All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS MODERATELY UP 10969All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411249All SZGR 2.0 genes in this pathway
WANG PROSTATE CANCER ANDROGEN INDEPENDENT 6637All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183111All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING DN 6844All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA DN 4127All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544307All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244165All SZGR 2.0 genes in this pathway
DELASERNA MYOD TARGETS UP 8951All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR DN 160101All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393244All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491310All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS DN 10563All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202132All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP 295149All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION C 6949All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535325All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE UP 10467All SZGR 2.0 genes in this pathway
NIELSEN GIST 9866All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 15099All SZGR 2.0 genes in this pathway
RAGHAVACHARI PLATELET SPECIFIC GENES 7046All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397206All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244157All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway