Gene Page: PRKCB

Summary
GeneID  5579
Symbol  PRKCB
Synonyms  MGC41878|PKC-beta|PKCB|PRKCB1|PRKCB2
Description  protein kinase C, beta
See related  HGNC:9395|MIM:176970|Ensembl:ENSG00000166501|HPRD:01499|
Locus tag  -
Gene type  protein-coding
Map location  16p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 9.3648 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ACAP20.880.86
CLCN30.880.89
CPD0.870.87
SNX130.870.86
KIAA07760.860.83
ITCH0.860.83
TM9SF30.860.87
GFM10.860.87
FAR10.860.83
EEA10.860.86
Top 10 negatively co-expressed genes
C1orf61-0.48-0.55
AF347015.21-0.48-0.38
AL022328.1-0.47-0.50
NUDT8-0.45-0.51
ENHO-0.45-0.49
IL32-0.45-0.40
C1orf54-0.44-0.41
CSAG1-0.43-0.40
MT-CO2-0.42-0.41
HIGD1B-0.41-0.40
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004697protein kinase C activityTAS3755548 
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI9765207 
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0019992diacylglycerol bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationTAS3755548 
GO:0007242intracellular signaling cascadeIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9814702 
GO:0005737cytoplasmTAS10828076 
GO:0005886plasma membraneEXP9814702 |10194441 |10856305 
GO:0005886plasma membraneTAS10828076 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADRBK1BARK1 | BETA-ARK1 | FLJ16718 | GRK2adrenergic, beta, receptor kinase 1-HPRD12456365 
Affinity Capture-Western
Reconstituted Complex		BioGRID12679936 
AFAP1AFAP | AFAP-110 | FLJ56849actin filament associated protein 1-HPRD,BioGRID12134071 
BTKAGMX1 | AT | ATK | BPK | IMD1 | MGC126261 | MGC126262 | PSCTK1 | XLABruton agammaglobulinemia tyrosine kinaseReconstituted ComplexBioGRID12679936 
CDC2CDC28A | CDK1 | DKFZp686L20222 | MGC111195cell division cycle 2, G1 to S and G2 to MAffinity Capture-WesternBioGRID11901153 
CSF2RBCD131 | CDw131 | IL3RB | IL5RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)Affinity Capture-WesternBioGRID10490850 
EIF62 | CAB | EIF3A | ITGB4BP | b | b(2)gcn | gcn | p27BBPeukaryotic translation initiation factor 6-HPRD14654845 
GCNT1C2GNT | C2GNT-L | C2GNT1 | G6NT | MGC126335 | MGC126336 | NACGT2 | NAGCT2glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)-HPRD12765965 
GNA12MGC104623 | MGC99644 | NNX3 | RMP | gepguanine nucleotide binding protein (G protein) alpha 12Biochemical ActivityBioGRID8824244 
GNA13G13 | MGC46138guanine nucleotide binding protein (G protein), alpha 13-HPRD,BioGRID8824244 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1Affinity Capture-Western
Reconstituted Complex		BioGRID10480917 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD10862698 
GSK3B-glycogen synthase kinase 3 beta-HPRD1324914 
HABP4IHABP4 | Ki-1/57 | MGC825 | SERBP1Lhyaluronan binding protein 4-HPRD14699138 
LMNB1ADLD | LMN | LMN2 | LMNB | MGC111419lamin B1-HPRD,BioGRID11901153 
MAPK6DKFZp686F03189 | ERK3 | HsT17250 | PRKM6 | p97MAPKmitogen-activated protein kinase 6-HPRD8626698 
MKI67KIA | Ki-67antigen identified by monoclonal antibody Ki-67-HPRD10502411 
NCAM1CD56 | MSK39 | NCAMneural cell adhesion molecule 1Affinity Capture-WesternBioGRID12743109 
NCF1FLJ79451 | NCF1A | NOXO2 | SH3PXD1A | p47phoxneutrophil cytosolic factor 1Affinity Capture-WesternBioGRID11120743 
PDLIM5ENH | ENH1 | L9 | LIMPDZ and LIM domain 5-HPRD,BioGRID8940095 
PDLIM7LMP1PDZ and LIM domain 7 (enigma)-HPRD8940095 
PDPK1MGC20087 | MGC35290 | PDK1 | PRO04613-phosphoinositide dependent protein kinase-1-HPRD,BioGRID11376011 
RASGRP3GRP3 | KIAA0846RAS guanyl releasing protein 3 (calcium and DAG-regulated)Biochemical ActivityBioGRID15213298 
RGS2G0S8regulator of G-protein signaling 2, 24kDa-HPRD,BioGRID11063746 
RIPK4ANKK2 | ANKRD3 | DIK | MGC129992 | MGC129993 | PKK | RIP4receptor-interacting serine-threonine kinase 4-HPRD,BioGRID11278382 
SPTAN1(ALPHA)II-SPECTRIN | FLJ44613 | NEASspectrin, alpha, non-erythrocytic 1 (alpha-fodrin)-HPRD8163551 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)An unspecified isoform of PKC-beta interacts with Stat3.BIND10446219 
TIAM1FLJ36302T-cell lymphoma invasion and metastasis 1Biochemical ActivityBioGRID10212259 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide-HPRD,BioGRID10433554 
ZMYND8MGC31836 | PRKCBP1 | PRO2893 | RACK7zinc finger, MYND-type containing 8-HPRD11003709 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 7656All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
KEGG_WNT_SIGNALING_PATHWAY 151112All SZGR genes in this pathway
KEGG_VEGF_SIGNALING_PATHWAY 7653All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 7556All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 7958All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 11878All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 4229All SZGR genes in this pathway
KEGG_VIBRIO_CHOLERAE_INFECTION 5632All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_GLIOMA 6556All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER 5447All SZGR genes in this pathway
BIOCARTA_SRCRPTP_PATHWAY 119All SZGR genes in this pathway
BIOCARTA_AT1R_PATHWAY 3628All SZGR genes in this pathway
BIOCARTA_CHEMICAL_PATHWAY 2215All SZGR genes in this pathway
BIOCARTA_SPPA_PATHWAY 2218All SZGR genes in this pathway
BIOCARTA_AGPCR_PATHWAY 1312All SZGR genes in this pathway
BIOCARTA_BCR_PATHWAY 3728All SZGR genes in this pathway
BIOCARTA_BIOPEPTIDES_PATHWAY 4535All SZGR genes in this pathway
BIOCARTA_CDMAC_PATHWAY 1615All SZGR genes in this pathway
BIOCARTA_CBL_PATHWAY 1310All SZGR genes in this pathway
BIOCARTA_CCR3_PATHWAY 2321All SZGR genes in this pathway
BIOCARTA_CXCR4_PATHWAY 2422All SZGR genes in this pathway
BIOCARTA_CALCINEURIN_PATHWAY 2117All SZGR genes in this pathway
BIOCARTA_EGF_PATHWAY 3125All SZGR genes in this pathway
BIOCARTA_FCER1_PATHWAY 4130All SZGR genes in this pathway
BIOCARTA_GH_PATHWAY 2822All SZGR genes in this pathway
BIOCARTA_KERATINOCYTE_PATHWAY 4638All SZGR genes in this pathway
BIOCARTA_PYK2_PATHWAY 3124All SZGR genes in this pathway
BIOCARTA_PPARA_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_NOS1_PATHWAY 2421All SZGR genes in this pathway
BIOCARTA_ARENRF2_PATHWAY 139All SZGR genes in this pathway
BIOCARTA_PDGF_PATHWAY 3225All SZGR genes in this pathway
BIOCARTA_CCR5_PATHWAY 2016All SZGR genes in this pathway
BIOCARTA_EDG1_PATHWAY 2724All SZGR genes in this pathway
BIOCARTA_MYOSIN_PATHWAY 3122All SZGR genes in this pathway
BIOCARTA_EIF4_PATHWAY 2419All SZGR genes in this pathway
BIOCARTA_CARDIACEGF_PATHWAY 1816All SZGR genes in this pathway
BIOCARTA_MEF2D_PATHWAY 2316All SZGR genes in this pathway
BIOCARTA_GPCR_PATHWAY 3731All SZGR genes in this pathway
BIOCARTA_TCR_PATHWAY 4937All SZGR genes in this pathway
BIOCARTA_PAR1_PATHWAY 3728All SZGR genes in this pathway
BIOCARTA_TPO_PATHWAY 2417All SZGR genes in this pathway
BIOCARTA_CREB_PATHWAY 2725All SZGR genes in this pathway
BIOCARTA_TRKA_PATHWAY 1210All SZGR genes in this pathway
BIOCARTA_VEGF_PATHWAY 2918All SZGR genes in this pathway
PID_FCER1_PATHWAY 6243All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY 6352All SZGR genes in this pathway
PID_TCR_PATHWAY 6651All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY 5342All SZGR genes in this pathway
PID_TXA2PATHWAY 5743All SZGR genes in this pathway
PID_NFAT_3PATHWAY 5447All SZGR genes in this pathway
PID_IL2_1PATHWAY 5543All SZGR genes in this pathway
PID_TCR_RAS_PATHWAY 1414All SZGR genes in this pathway
PID_TCR_JNK_PATHWAY 1411All SZGR genes in this pathway
PID_IL8_CXCR2_PATHWAY 3426All SZGR genes in this pathway
PID_VEGFR1_PATHWAY 2623All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY 6957All SZGR genes in this pathway
PID_THROMBIN_PAR1_PATHWAY 4332All SZGR genes in this pathway
PID_IL8_CXCR1_PATHWAY 2819All SZGR genes in this pathway
PID_RAS_PATHWAY 3022All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY 6556All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 9766All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 6443All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 8956All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 2823All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS 1611All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS 4429All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_DN 17582All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_UP 9564All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP 12672All SZGR genes in this pathway
VANHARANTA_UTERINE_FIBROID_UP 4526All SZGR genes in this pathway
SHI_SPARC_TARGETS_UP 2417All SZGR genes in this pathway
WATTEL_AUTONOMOUS_THYROID_ADENOMA_UP 7347All SZGR genes in this pathway
BALLIF_DEVELOPMENTAL_DISABILITY_P16_P12_DELETION 138All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP 176115All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX4_UP 118All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_DN 165104All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
SHIPP_DLBCL_CURED_VS_FATAL_DN 4530All SZGR genes in this pathway
BASSO_B_LYMPHOCYTE_NETWORK 14396All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 8758All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_UP 203130All SZGR genes in this pathway
ZHANG_TARGETS_OF_EWSR1_FLI1_FUSION 8868All SZGR genes in this pathway
HOFMANN_CELL_LYMPHOMA_UP 5035All SZGR genes in this pathway
YU_MYC_TARGETS_DN 5538All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_VS_CD2_DN 5235All SZGR genes in this pathway
MCCLUNG_DELTA_FOSB_TARGETS_8WK 4738All SZGR genes in this pathway
MODY_HIPPOCAMPUS_POSTNATAL 6350All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
RAMALHO_STEMNESS_DN 7455All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_DN 178121All SZGR genes in this pathway
JOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_UP 3121All SZGR genes in this pathway
DURCHDEWALD_SKIN_CARCINOGENESIS_UP 8847All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
FINETTI_BREAST_CANCER_KINOME_GREEN 1614All SZGR genes in this pathway
OUYANG_PROSTATE_CANCER_PROGRESSION_UP 2014All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
CHUNG_BLISTER_CYTOTOXICITY_DN 4429All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_DN 9753All SZGR genes in this pathway
NAKAMURA_METASTASIS 4728All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_DN 235144All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
HOFMANN_MYELODYSPLASTIC_SYNDROM_LOW_RISK_UP 2215All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE 200115All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP 288168All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
RAGHAVACHARI_PLATELET_SPECIFIC_GENES 7046All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_DN 11683All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
WIERENGA_PML_INTERACTOME 4223All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-129-5p8228291A,m8hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-1841622m8hsa-miR-184UGGACGGAGAACUGAUAAGGGU
miR-1948648701Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-203.17717781A,m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-3309189251A,m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-4508228281Ahsa-miR-450UUUUUGCGAUGUGUUCCUAAUA
miR-4941281341Ahsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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