Gene Page: C20orf24

Summary ?
GeneID55969
SymbolC20orf24
SynonymsPNAS-11|RIP5
Descriptionchromosome 20 open reading frame 24
ReferenceHGNC:HGNC:15870|Ensembl:ENSG00000101084|HPRD:12761|Vega:OTTHUMG00000032384
Gene typeprotein-coding
Map location20q11.23
Pascal p-value0.624
Sherlock p-value0.114
Fetal beta-0.364
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 6

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg047597562035273933C20orf243.48E-63.804DMG:vanEijk_2014
cg047597562035273933C20orf241.79E-63.481DMG:vanEijk_2014
cg047597562035273933C20orf241.66E-53.194DMG:vanEijk_2014
cg216714762035169609C20orf245.382E-4-3.896DMG:vanEijk_2014
cg216714762035169609C20orf248.014E-4-4.197DMG:vanEijk_2014
cg216714762035169609C20orf246.3E-5-4.427DMG:vanEijk_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6902183chr6121963786C20orf24559690.16trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABCD3ABC43 | PMP70 | PXMP1ATP-binding cassette, sub-family D (ALD), member 3Affinity Capture-MSBioGRID17353931 
AIFM1AIF | MGC111425 | PDCD8apoptosis-inducing factor, mitochondrion-associated, 1Affinity Capture-MSBioGRID17353931 
ATAD3AFLJ10709ATPase family, AAA domain containing 3AAffinity Capture-MSBioGRID17353931 
ATAD3BAAA-TOB3 | KIAA1273 | TOB3ATPase family, AAA domain containing 3BAffinity Capture-MSBioGRID17353931 
CLPX-ClpX caseinolytic peptidase X homolog (E. coli)Affinity Capture-MSBioGRID17353931 
DDX3XDBX | DDX14 | DDX3 | HLP2DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linkedAffinity Capture-MSBioGRID17353931 
DYNC1H1DHC1 | DHC1a | DKFZp686P2245 | DNCH1 | DNCL | DNECL | DYHC | Dnchc1 | HL-3 | KIAA0325 | p22dynein, cytoplasmic 1, heavy chain 1Affinity Capture-MSBioGRID17353931 
FANCIFLJ10719 | KIAA1794Fanconi anemia, complementation group IAffinity Capture-MSBioGRID17353931 
FAR1DKFZp686A0370 | DKFZp686P18247 | FLJ22728 | FLJ33561 | MLSTD2fatty acyl CoA reductase 1Affinity Capture-MSBioGRID17353931 
GCN1L1GCN1 | GCN1L | KIAA0219GCN1 general control of amino-acid synthesis 1-like 1 (yeast)Affinity Capture-MSBioGRID17353931 
IPO11RanBP11importin 11Affinity Capture-MSBioGRID17353931 
PSMD3P58 | RPN3 | S3proteasome (prosome, macropain) 26S subunit, non-ATPase, 3Affinity Capture-MSBioGRID17353931 
PTPLAD1B-IND1 | FLJ90376 | HSPC121protein tyrosine phosphatase-like A domain containing 1Affinity Capture-MSBioGRID17353931 
RFXANKANKRA1 | BLS | F14150_1 | MGC138628 | RFX-Bregulatory factor X-associated ankyrin-containing proteinAffinity Capture-MSBioGRID17353931 
SLC25A12ARALAR | ARALAR1solute carrier family 25 (mitochondrial carrier, Aralar), member 12Affinity Capture-MSBioGRID17353931 
SPTLC1HSAN | HSAN1 | HSN1 | LBC1 | LCB1 | MGC14645 | SPT1 | SPTIserine palmitoyltransferase, long chain base subunit 1Affinity Capture-MSBioGRID17353931 
SSR3TRAPGsignal sequence receptor, gamma (translocon-associated protein gamma)Affinity Capture-MSBioGRID17353931 
SSR4TRAPDsignal sequence receptor, delta (translocon-associated protein delta)Affinity Capture-MSBioGRID17353931 
SURF4ERV29 | FLJ22993 | MGC102753surfeit 4Affinity Capture-MSBioGRID17353931 
TNPO3IPO12 | MTR10A | TRN-SR | TRN-SR2 | TRNSRtransportin 3Affinity Capture-MSBioGRID17353931 
XPO7KIAA0745 | RANBP16exportin 7Affinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285181All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP 15184All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633376All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP 14296All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162104All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP 147101All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146104All SZGR 2.0 genes in this pathway
CHOI ATL STAGE PREDICTOR 4424All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
GOLDRATH HOMEOSTATIC PROLIFERATION 171102All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C1 7245All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN 414237All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448282All SZGR 2.0 genes in this pathway