Gene Page: MAP2K7
Summary ?
| GeneID | 5609 |
| Symbol | MAP2K7 |
| Synonyms | JNKK2|MAPKK7|MEK|MEK 7|MKK7|PRKMK7|SAPKK-4|SAPKK4 |
| Description | mitogen-activated protein kinase kinase 7 |
| Reference | MIM:603014|HGNC:HGNC:6847|Ensembl:ENSG00000076984|Vega:OTTHUMG00000137368 |
| Gene type | protein-coding |
| Map location | 19p13.3-p13.2 |
| Pascal p-value | 0.036 |
| Fetal beta | 0.185 |
| DMG | 1 (# studies) |
| eGene | Cerebellar Hemisphere |
| Support | CANABINOID DOPAMINE SEROTONIN G2Cdb.humanNRC G2Cdb.humanPSP |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg05512505 | 19 | 7968863 | MAP2K7 | 3.945E-4 | -0.352 | 0.043 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TMEM66 | 0.87 | 0.87 |
| ATP6AP2 | 0.83 | 0.85 |
| MAPRE3 | 0.83 | 0.83 |
| AP2M1 | 0.83 | 0.82 |
| CALM3 | 0.82 | 0.83 |
| ACP2 | 0.82 | 0.79 |
| ATP6AP1 | 0.82 | 0.80 |
| ARF3 | 0.81 | 0.84 |
| ENTPD6 | 0.81 | 0.82 |
| SCAMP5 | 0.81 | 0.80 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.18 | -0.53 | -0.35 |
| AF347015.21 | -0.50 | -0.27 |
| AC098691.2 | -0.49 | -0.39 |
| AF347015.26 | -0.48 | -0.28 |
| AF347015.2 | -0.47 | -0.26 |
| MT-CO2 | -0.47 | -0.29 |
| AC010300.1 | -0.45 | -0.37 |
| AF347015.8 | -0.44 | -0.27 |
| NOSTRIN | -0.44 | -0.26 |
| MT-CYB | -0.43 | -0.26 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CNKSR1 | CNK | CNK1 | KSR | connector enhancer of kinase suppressor of Ras 1 | CNKSR1 (hCNK1) interacts with MAP2K7 (MKK7). This interaction was modelled on a demonstrated interaction between human CNKSR1 and MAP2K7 from an unspecified species. | BIND | 15753034 |
| DUSP19 | DUSP17 | LMWDSP3 | MGC138210 | SKRP1 | TS-DSP1 | dual specificity phosphatase 19 | - | HPRD,BioGRID | 11959861 |11959862 |
| DUSP22 | JKAP | JSP1 | MKPX | VHX | dual specificity phosphatase 22 | - | HPRD | 12138158 |
| GADD45B | DKFZp566B133 | GADD45BETA | MYD118 | growth arrest and DNA-damage-inducible, beta | Affinity Capture-Western Reconstituted Complex | BioGRID | 14743220 |
| MAP2K4 | JNKK | JNKK1 | MAPKK4 | MEK4 | MKK4 | PRKMK4 | SEK1 | SERK1 | mitogen-activated protein kinase kinase 4 | Phenotypic Enhancement | BioGRID | 11062067 |
| MAP2K7 | Jnkk2 | MAPKK7 | MKK7 | PRKMK7 | mitogen-activated protein kinase kinase 7 | MKK7 autophosphorylates. This interaction was modeled on a demonstrated interaction using MKK7 from an unspecified species. | BIND | 10347227 |
| MAP3K1 | MAPKKK1 | MEKK | MEKK1 | mitogen-activated protein kinase kinase kinase 1 | MEKK1 interacts with MEK7. | BIND | 10969079 |
| MAP3K1 | MAPKKK1 | MEKK | MEKK1 | mitogen-activated protein kinase kinase kinase 1 | MKK7 interacts with MEKK1. This interaction was modeled on a demonstrated interaction between human MKK7 and rat MEKK1. | BIND | 15866172 |
| MAP3K11 | MGC17114 | MLK-3 | MLK3 | PTK1 | SPRK | mitogen-activated protein kinase kinase kinase 11 | MAP3K11 (MLK3) phosphorylates MAP2K7 (MKK7). This interaction was modeled on a demonstrated interaction between human MAP3K11 and MAP2K7 from an unspecified species. | BIND | 15001580 |
| MAP3K11 | MGC17114 | MLK-3 | MLK3 | PTK1 | SPRK | mitogen-activated protein kinase kinase kinase 11 | - | HPRD,BioGRID | 10187804 |
| MAP3K12 | DLK | MUK | ZPK | ZPKP1 | mitogen-activated protein kinase kinase kinase 12 | - | HPRD,BioGRID | 10187804 |
| MAP3K13 | LZK | MGC133196 | mitogen-activated protein kinase kinase kinase 13 | Biochemical Activity | BioGRID | 11726277 |
| MAP3K2 | MEKK2 | MEKK2B | mitogen-activated protein kinase kinase kinase 2 | MEKK2 phosphorylates MKK7. This interaction was modeled on a demonstrated interaction between MEKK2 from an unspecified species and MKK7 from an unspecified species. | BIND | 12659851 |
| MAP3K2 | MEKK2 | MEKK2B | mitogen-activated protein kinase kinase kinase 2 | - | HPRD,BioGRID | 10713157 |
| MAP3K5 | ASK1 | MAPKKK5 | MEKK5 | mitogen-activated protein kinase kinase kinase 5 | Affinity Capture-Western | BioGRID | 11959862 |
| MAPK14 | CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHA | mitogen-activated protein kinase 14 | Biochemical Activity | BioGRID | 9207092 |
| MAPK8 | JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1 | mitogen-activated protein kinase 8 | - | HPRD,BioGRID | 9207092 |
| MAPK8 | JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1 | mitogen-activated protein kinase 8 | MKK7 phosphorylates JNK1. This interaction was modeled on a demonstrated interaction between MKK7 from an unspecified species and JNK1 from an unspecified species. | BIND | 12659851 |
| MAPK8IP1 | IB1 | JIP-1 | JIP1 | PRKM8IP | mitogen-activated protein kinase 8 interacting protein 1 | - | HPRD,BioGRID | 10490659 |
| MAPK8IP2 | IB2 | JIP2 | PRKM8IPL | mitogen-activated protein kinase 8 interacting protein 2 | - | HPRD,BioGRID | 10756100 |
| MAPK8IP3 | DKFZp762N1113 | FLJ00027 | JIP3 | JSAP1 | KIAA1066 | SYD2 | mitogen-activated protein kinase 8 interacting protein 3 | - | HPRD,BioGRID | 10629060 |12189133 |
| ZAK | AZK | MLK7 | MLT | MLTK | MRK | mlklak | sterile alpha motif and leucine zipper containing kinase AZK | - | HPRD,BioGRID | 11836244 |15465036 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG MAPK SIGNALING PATHWAY | 267 | 205 | All SZGR 2.0 genes in this pathway |
| KEGG ERBB SIGNALING PATHWAY | 87 | 71 | All SZGR 2.0 genes in this pathway |
| KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY | 102 | 88 | All SZGR 2.0 genes in this pathway |
| KEGG T CELL RECEPTOR SIGNALING PATHWAY | 108 | 89 | All SZGR 2.0 genes in this pathway |
| KEGG FC EPSILON RI SIGNALING PATHWAY | 79 | 58 | All SZGR 2.0 genes in this pathway |
| KEGG NEUROTROPHIN SIGNALING PATHWAY | 126 | 103 | All SZGR 2.0 genes in this pathway |
| KEGG GNRH SIGNALING PATHWAY | 101 | 77 | All SZGR 2.0 genes in this pathway |
| BIOCARTA FCER1 PATHWAY | 41 | 30 | All SZGR 2.0 genes in this pathway |
| BIOCARTA HIVNEF PATHWAY | 58 | 43 | All SZGR 2.0 genes in this pathway |
| BIOCARTA KERATINOCYTE PATHWAY | 46 | 38 | All SZGR 2.0 genes in this pathway |
| BIOCARTA MAPK PATHWAY | 87 | 68 | All SZGR 2.0 genes in this pathway |
| ST DIFFERENTIATION PATHWAY IN PC12 CELLS | 45 | 35 | All SZGR 2.0 genes in this pathway |
| SIG CD40PATHWAYMAP | 34 | 28 | All SZGR 2.0 genes in this pathway |
| ST GRANULE CELL SURVIVAL PATHWAY | 27 | 23 | All SZGR 2.0 genes in this pathway |
| ST INTEGRIN SIGNALING PATHWAY | 82 | 62 | All SZGR 2.0 genes in this pathway |
| ST JNK MAPK PATHWAY | 40 | 30 | All SZGR 2.0 genes in this pathway |
| ST FAS SIGNALING PATHWAY | 65 | 54 | All SZGR 2.0 genes in this pathway |
| PID FCER1 PATHWAY | 62 | 43 | All SZGR 2.0 genes in this pathway |
| PID REELIN PATHWAY | 29 | 29 | All SZGR 2.0 genes in this pathway |
| PID CDC42 PATHWAY | 70 | 51 | All SZGR 2.0 genes in this pathway |
| PID FAS PATHWAY | 38 | 29 | All SZGR 2.0 genes in this pathway |
| PID TNF PATHWAY | 46 | 33 | All SZGR 2.0 genes in this pathway |
| PID PDGFRB PATHWAY | 129 | 103 | All SZGR 2.0 genes in this pathway |
| PID HIV NEF PATHWAY | 35 | 26 | All SZGR 2.0 genes in this pathway |
| PID ANTHRAX PATHWAY | 17 | 15 | All SZGR 2.0 genes in this pathway |
| PID RAC1 PATHWAY | 54 | 37 | All SZGR 2.0 genes in this pathway |
| REACTOME TRIF MEDIATED TLR3 SIGNALING | 74 | 54 | All SZGR 2.0 genes in this pathway |
| REACTOME MAP KINASE ACTIVATION IN TLR CASCADE | 50 | 37 | All SZGR 2.0 genes in this pathway |
| REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | 16 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION | 77 | 57 | All SZGR 2.0 genes in this pathway |
| REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE | 72 | 53 | All SZGR 2.0 genes in this pathway |
| REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | 83 | 63 | All SZGR 2.0 genes in this pathway |
| REACTOME INNATE IMMUNE SYSTEM | 279 | 178 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATED TLR4 SIGNALLING | 93 | 69 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME TOLL RECEPTOR CASCADES | 118 | 84 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
| DAIRKEE TERT TARGETS UP | 380 | 213 | All SZGR 2.0 genes in this pathway |
| RICKMAN METASTASIS DN | 261 | 155 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| MATSUDA NATURAL KILLER DIFFERENTIATION | 475 | 313 | All SZGR 2.0 genes in this pathway |
| NUMATA CSF3 SIGNALING VIA STAT3 | 22 | 17 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN | 274 | 165 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER GOOD SURVIVAL A12 | 317 | 177 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA | 43 | 27 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA CHEMOTAXIS UP | 74 | 45 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS UP | 518 | 299 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS UP | 504 | 321 | All SZGR 2.0 genes in this pathway |