Gene Page: PTGS2

Summary
GeneID  5743
Symbol  PTGS2
Synonyms  COX-2|COX2|GRIPGHS|PGG/HS|PGHS-2|PHS-2|hCox-2
Description  prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
See related  HGNC:9605|MIM:600262|Ensembl:ENSG00000073756|HPRD:02599|
Locus tag  -
Gene type  protein-coding
Map location  1q25.2-q25.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PLCB40.860.81
CYLD0.840.78
AKAP20.840.75
MTMR70.840.86
PHACTR20.830.64
TBK10.820.79
PALM2-AKAP20.820.77
ADAM230.820.77
KCNH50.810.71
TLK10.810.76
Top 10 negatively co-expressed genes
EFEMP2-0.42-0.57
RAB34-0.38-0.55
GATSL3-0.37-0.53
CLEC3B-0.37-0.55
SLC2A4RG-0.37-0.49
C16orf74-0.36-0.53
EIF4EBP3-0.36-0.52
C1orf61-0.36-0.62
CSAG1-0.36-0.49
METRN-0.35-0.52
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004601peroxidase activityEXP4514999 
GO:0004601peroxidase activityIEA-
GO:0004601peroxidase activityNAS14511332 
GO:0005506iron ion bindingIEA-
GO:0004666prostaglandin-endoperoxide synthase activityIEA-
GO:0004666prostaglandin-endoperoxide synthase activityNAS14511332 
GO:0020037heme bindingIEA-
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenIEA-
GO:0016491oxidoreductase activityIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008217regulation of blood pressureIEA-
GO:0008217regulation of blood pressureISS-
GO:0006979response to oxidative stressIEA-
GO:0006928cell motionTAS9630216 
GO:0006633fatty acid biosynthetic processIEA-
GO:0019371cyclooxygenase pathwayNAS14511332 
GO:0042640anagenIEA-
GO:0050727regulation of inflammatory responseNAS14511332 
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeIEA-
GO:0005788endoplasmic reticulum lumenEXP4514999 
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005634nucleusISS-
GO:0005737cytoplasmIDA14511332 
GO:0005737cytoplasmIEA-
GO:0005737cytoplasmISS-
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAT5D6S82E | NG26HLA-B associated transcript 5-HPRD14667819 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDa-HPRD,BioGRID11432874 
NUCB1DKFZp686A15286 | FLJ40471 | NUCnucleobindin 1-HPRD,BioGRID8643612 
PTGS2COX-2 | COX2 | GRIPGHS | PGG/HS | PGHS-2 | PHS-2 | hCox-2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)COX-2 forms a homodimer. This interaction was modelled on a demonstrated homodimerization of mouse COX-1.BIND10811226 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID11687965 
COX-2 interacts with p53.BIND15608668 
ZFP36G0S24 | GOS24 | NUP475 | RNF162A | TIS11 | TTPzinc finger protein 36, C3H type, homolog (mouse)TTP interacts with Cox2 mRNA. This interaction was modelled on a demonstrated interaction between TTP and Cox2 mRNA, both from unspecified species.BIND15766526 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ARACHIDONIC_ACID_METABOLISM 5836All SZGR genes in this pathway
KEGG_VEGF_SIGNALING_PATHWAY 7653All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_SMALL_CELL_LUNG_CANCER 8467All SZGR genes in this pathway
BIOCARTA_PPARA_PATHWAY 5843All SZGR genes in this pathway
PID_NFAT_TFPATHWAY 4739All SZGR genes in this pathway
PID_S1P_S1P1_PATHWAY 2118All SZGR genes in this pathway
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY 3829All SZGR genes in this pathway
PID_TCR_CALCIUM_PATHWAY 2923All SZGR genes in this pathway
REACTOME_BIOLOGICAL_OXIDATIONS 13991All SZGR genes in this pathway
REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS 7050All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
PUIFFE_INVASION_INHIBITED_BY_ASCITES_DN 14591All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_MAGENTA_UP 2818All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP 182110All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP 15791All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP 194122All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP 175108All SZGR genes in this pathway
AKL_HTLV1_INFECTION_DN 6841All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_2HR_DN 8853All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP 5733All SZGR genes in this pathway
GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP 6647All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP 6446All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_DN 5135All SZGR genes in this pathway
CHIN_BREAST_CANCER_COPY_NUMBER_UP 2718All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_FOREVER_DN 3123All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
MISSIAGLIA_REGULATED_BY_METHYLATION_UP 12678All SZGR genes in this pathway
DEBOSSCHER_NFKB_TARGETS_REPRESSED_BY_GLUCOCORTICOIDS 2418All SZGR genes in this pathway
AGARWAL_AKT_PATHWAY_TARGETS 109All SZGR genes in this pathway
TSUNODA_CISPLATIN_RESISTANCE_DN 5138All SZGR genes in this pathway
WOOD_EBV_EBNA1_TARGETS_DN 4733All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
GALIE_TUMOR_ANGIOGENESIS 87All SZGR genes in this pathway
GROSS_ELK3_TARGETS_DN 3217All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_DN 156106All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
RICKMAN_HEAD_AND_NECK_CANCER_C 11347All SZGR genes in this pathway
WU_CELL_MIGRATION 184114All SZGR genes in this pathway
AMIT_EGF_RESPONSE_40_HELA 4229All SZGR genes in this pathway
AMIT_EGF_RESPONSE_60_MCF10A 3924All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_60_MCF10A 5742All SZGR genes in this pathway
LIN_SILENCED_BY_TUMOR_MICROENVIRONMENT 10873All SZGR genes in this pathway
SUNG_METASTASIS_STROMA_UP 11070All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_6 119All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_DN 169102All SZGR genes in this pathway
ONDER_CDH1_TARGETS_3_DN 5932All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_UP 197110All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP 14591All SZGR genes in this pathway
GALINDO_IMMUNE_RESPONSE_TO_ENTEROTOXIN 8567All SZGR genes in this pathway
STOSSI_RESPONSE_TO_ESTRADIOL 5035All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
NEMETH_INFLAMMATORY_RESPONSE_LPS_UP 8864All SZGR genes in this pathway
HALMOS_CEBPA_TARGETS_UP 5234All SZGR genes in this pathway
NGUYEN_NOTCH1_TARGETS_DN 8667All SZGR genes in this pathway
BRUNO_HEMATOPOIESIS 6648All SZGR genes in this pathway
LIANG_SILENCED_BY_METHYLATION_2 5334All SZGR genes in this pathway
LY_AGING_PREMATURE_DN 3017All SZGR genes in this pathway
ABE_VEGFA_TARGETS_2HR 3421All SZGR genes in this pathway
SUZUKI_RESPONSE_TO_TSA_AND_DECITABINE_1A 2316All SZGR genes in this pathway
HARRIS_HYPOXIA 8164All SZGR genes in this pathway
CHANG_IMMORTALIZED_BY_HPV31_DN 6545All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
ZHU_CMV_ALL_UP 12089All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_2HR 5136All SZGR genes in this pathway
ZHOU_TNF_SIGNALING_30MIN 5436All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_UP 7757All SZGR genes in this pathway
ABE_VEGFA_TARGETS 2015All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_UP 12375All SZGR genes in this pathway
LY_AGING_OLD_DN 5635All SZGR genes in this pathway
LY_AGING_MIDDLE_DN 1610All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C3 2015All SZGR genes in this pathway
ABE_VEGFA_TARGETS_30MIN 2921All SZGR genes in this pathway
ZHU_CMV_8_HR_UP 4739All SZGR genes in this pathway
BURTON_ADIPOGENESIS_9 9259All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
DURCHDEWALD_SKIN_CARCINOGENESIS_DN 264168All SZGR genes in this pathway
SANSOM_WNT_PATHWAY_REQUIRE_MYC 5843All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
HOQUE_METHYLATED_IN_CANCER 5645All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
MATZUK_OVULATION 1410All SZGR genes in this pathway
MATZUK_IMPLANTATION_AND_UTERINE 2215All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_UP 10264All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_UP 11170All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP 223132All SZGR genes in this pathway
MATTHEWS_AP1_TARGETS 1712All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
FERRARI_RESPONSE_TO_FENRETINIDE_UP 2216All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
TAVAZOIE_METASTASIS 10868All SZGR genes in this pathway
LEE_LIVER_CANCER_HEPATOBLAST 1612All SZGR genes in this pathway
SCHOEN_NFKB_SIGNALING 3426All SZGR genes in this pathway
LI_PROSTATE_CANCER_EPIGENETIC 3022All SZGR genes in this pathway
UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN 3726All SZGR genes in this pathway
TIAN_TNF_SIGNALING_VIA_NFKB 2821All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G28 2011All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_UP 5541All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
AZARE_NEOPLASTIC_TRANSFORMATION_BY_STAT3_UP 12170All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
WINZEN_DEGRADED_VIA_KHSRP 10070All SZGR genes in this pathway
KUWANO_RNA_STABILIZED_BY_NO 77All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_1HR_UP 3426All SZGR genes in this pathway
PLASARI_TGFB1_TARGETS_10HR_UP 199143All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_A 182108All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
GHANDHI_DIRECT_IRRADIATION_UP 11068All SZGR genes in this pathway
GHANDHI_BYSTANDER_IRRADIATION_UP 8654All SZGR genes in this pathway
ZWANG_CLASS_3_TRANSIENTLY_INDUCED_BY_EGF 222159All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101173717441A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-143171117171Ahsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
miR-144173817441Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-262572641A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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