Gene Page: ALS2

Summary
GeneID  57679
Symbol  ALS2
Synonyms  ALS2CR6|ALSJ|FLJ31851|IAHSP|KIAA1563|MGC87187|PLSJ
Description  amyotrophic lateral sclerosis 2 (juvenile)
See related  HGNC:443|MIM:606352|Ensembl:ENSG00000003393|HPRD:05893|
Locus tag  -
Gene type  protein-coding
Map location  2q33.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005085guanyl-nucleotide exchange factor activityIDA15247254 
GO:0005087Ran guanyl-nucleotide exchange factor activityNAS11586298 
GO:0005515protein bindingIPI17239822 
GO:0017112Rab guanyl-nucleotide exchange factor activityIDA12837691 
GO:0017137Rab GTPase bindingIDA15247254 
GO:0017137Rab GTPase bindingNAS16670179 
GO:0042803protein homodimerization activityIPI15247254 
GO:0030676Rac guanyl-nucleotide exchange factor activityIDA16049005 
GO:0043539protein serine/threonine kinase activator activityIDA16049005 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007528neuromuscular junction developmentIEASynap (GO term level: 10)-
GO:0035249synaptic transmission, glutamatergicIEAneuron, glutamate, Synap, Neurotransmitter (GO term level: 8)-
GO:0048812neurite morphogenesisIDAneuron, axon, neurite, dendrite (GO term level: 11)16049005 
GO:0001662behavioral fear responseIEA-
GO:0001881receptor recyclingIEA-
GO:0016050vesicle organizationIEA-
GO:0007626locomotory behaviorIEA-
GO:0008104protein localizationIEA-
GO:0006979response to oxidative stressIEA-
GO:0007032endosome organizationNAS12837691 
GO:0016197endosome transportIEA-
GO:0035022positive regulation of Rac protein signal transductionIC16049005 
GO:0035023regulation of Rho protein signal transductionIEA-
GO:0051036regulation of endosome sizeIEP15247254 
GO:0032313regulation of Rab GTPase activityIEA-
GO:0032855positive regulation of Rac GTPase activityIDA16049005 
GO:0045860positive regulation of protein kinase activityIDA16049005 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0014069postsynaptic densityIEASynap (GO term level: 10)-
GO:0043197dendritic spineIEASynap, dendrite (GO term level: 7)-
GO:0001726ruffleISS-
GO:0005813centrosomeIDA16085057 
GO:0005829cytosolIDA12837691 
GO:0005622intracellularIEA-
GO:0005737cytoplasmIEA-
GO:0005769early endosomeIDA12837691 
GO:0030027lamellipodiumISS-
GO:0042598vesicular fractionIDA12837691 
GO:0043234protein complexIDA15247254 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 5343All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
KEEN_RESPONSE_TO_ROSIGLITAZONE_UP 3823All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_UP 10968All SZGR genes in this pathway
MARSON_FOXP3_TARGETS_DN 5438All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-142-5p120412111A,m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-14412341240m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-1997227291A,m8hsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-264484551A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-50587941A,m8hsa-miR-505GUCAACACUUGCUGGUUUCCUC
miR-54312451251m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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