Gene Page: PTPRH
Summary ?
| GeneID | 5794 |
| Symbol | PTPRH |
| Synonyms | R-PTP-H|SAP1 |
| Description | protein tyrosine phosphatase, receptor type H |
| Reference | MIM:602510|HGNC:HGNC:9672|Ensembl:ENSG00000080031|HPRD:03942|Vega:OTTHUMG00000180701 |
| Gene type | protein-coding |
| Map location | 19q13.4 |
| Pascal p-value | 0.016 |
| eGene | Cerebellum Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2870246 | chr4 | 91234497 | PTPRH | 5794 | 0.12 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TTC31 | 0.89 | 0.81 |
| CDK5RAP3 | 0.88 | 0.84 |
| LEPRE1 | 0.87 | 0.80 |
| METT11D1 | 0.87 | 0.84 |
| RGL2 | 0.86 | 0.87 |
| GUSB | 0.86 | 0.81 |
| SFRS6 | 0.86 | 0.79 |
| TTLL4 | 0.86 | 0.82 |
| STK36 | 0.86 | 0.84 |
| FANCA | 0.85 | 0.76 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.27 | -0.52 | -0.56 |
| AF347015.31 | -0.52 | -0.56 |
| MT-CO2 | -0.50 | -0.54 |
| AF347015.8 | -0.49 | -0.55 |
| MT-CYB | -0.48 | -0.53 |
| AF347015.21 | -0.48 | -0.60 |
| C5orf53 | -0.48 | -0.49 |
| AF347015.33 | -0.47 | -0.50 |
| AF347015.15 | -0.46 | -0.51 |
| MT-ATP8 | -0.44 | -0.59 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| JAZAG TGFB1 SIGNALING UP | 108 | 69 | All SZGR 2.0 genes in this pathway |
| PENG RAPAMYCIN RESPONSE UP | 203 | 130 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 | 720 | 440 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| GYORFFY DOXORUBICIN RESISTANCE | 56 | 34 | All SZGR 2.0 genes in this pathway |