Gene Page: ABCD3

Summary ?
GeneID5825
SymbolABCD3
SynonymsABC43|CBAS5|PMP70|PXMP1|ZWS2
DescriptionATP binding cassette subfamily D member 3
ReferenceMIM:170995|HGNC:HGNC:67|Ensembl:ENSG00000117528|HPRD:01368|Vega:OTTHUMG00000010717
Gene typeprotein-coding
Map location1p21.3
Pascal p-value0.595
Sherlock p-value0.36
Fetal beta0.568
DMG1 (# studies)
eGeneMyers' cis & trans
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg17906523194883536ABCD39.04E-9-0.014.12E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4847340chr195158602ABCD358250.12cis

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABCD1ABC42 | ALD | ALDP | AMNATP-binding cassette, sub-family D (ALD), member 1Heterodimerization of ALDP with PMP70.BIND10551832 
ABCD1ABC42 | ALD | ALDP | AMNATP-binding cassette, sub-family D (ALD), member 1-HPRD,BioGRID10551832 
ABCD2ABC39 | ALDL1 | ALDR | ALDRP | hALDRATP-binding cassette, sub-family D (ALD), member 2PMP70 interacts with ALDRP. This interaction was modelled on a demonstrated interaction between human PMP70 and mouse ALDRP.BIND10551832 
ABCD3ABC43 | PMP70 | PXMP1ATP-binding cassette, sub-family D (ALD), member 3PMP70 homodimerizes via the carboxy-terminal half.BIND10551832 
BRF2BRFU | FLJ11052 | TFIIIB50BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-likeAffinity Capture-MSBioGRID17353931 
C20orf24PNAS-11 | RIP5chromosome 20 open reading frame 24Affinity Capture-MSBioGRID17353931 
COL6A2DKFZp586E1322 | FLJ46862 | PP3610collagen, type VI, alpha 2-HPRD12176987 
MESTDKFZp686L18234 | MGC111102 | MGC8703 | PEG1mesoderm specific transcript homolog (mouse)Affinity Capture-MSBioGRID17353931 
MLF2NTN4myeloid leukemia factor 2Affinity Capture-MSBioGRID17353931 
PELOCGI-17 | PRO1770pelota homolog (Drosophila)Affinity Capture-MSBioGRID17353931 
PEX19D1S2223E | HK33 | PMP1 | PMPI | PXF | PXMP1peroxisomal biogenesis factor 19PMP70 interacts with both farnesylated and mutant farnesyl-deficient PEX19.BIND10777694 
PEX19D1S2223E | HK33 | PMP1 | PMPI | PXF | PXMP1peroxisomal biogenesis factor 19-HPRD,BioGRID10777694 |11453642 
PGRMC1HPR6.6 | MPRprogesterone receptor membrane component 1Affinity Capture-MSBioGRID17353931 
PTP4A3PRL-3 | PRL-R | PRL3protein tyrosine phosphatase type IVA, member 3Affinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ABC TRANSPORTERS 4429All SZGR 2.0 genes in this pathway
KEGG PEROXISOME 7847All SZGR 2.0 genes in this pathway
REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS 1811All SZGR 2.0 genes in this pathway
REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT 3421All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE UP 10867All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE DN 8453All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
LIU VMYB TARGETS UP 12778All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455304All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310188All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP 181101All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265158All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 UP 13784All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633376All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206136All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 DN 6438All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309206All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA DN 7445All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C4 2014All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION UP 8349All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262186All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198132All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
MALONEY RESPONSE TO 17AAG DN 7945All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342220All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
ZHAN EARLY DIFFERENTIATION GENES DN 4229All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2 11574All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317190All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337236All SZGR 2.0 genes in this pathway