Summary ?
GeneID5830
SymbolPEX5
SynonymsPBD2A|PBD2B|PTS1-BP|PTS1R|PXR1|RCDP5
Descriptionperoxisomal biogenesis factor 5
ReferenceMIM:600414|HGNC:HGNC:9719|Ensembl:ENSG00000139197|HPRD:02684|Vega:OTTHUMG00000168175
Gene typeprotein-coding
Map location12p13.31
Pascal p-value0.05
Sherlock p-value0.112
Fetal beta-0.319
DMG3 (# studies)
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 3
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg05236530127362357PEX55.888E-40.3640.05DMG:Wockner_2014
cg15754084127343020PEX5-0.0380.87DMG:Nishioka_2013
cg07748017127342621PEX55.83E-8-0.0121.49E-5DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2456470chr1562777955PEX558300.19trans
rs2053887127346530PEX5ENSG00000139197.61.478E-60.015249gtex_brain_ba24
rs12830671127347278PEX5ENSG00000139197.68.763E-70.015997gtex_brain_ba24
rs12820829127347534PEX5ENSG00000139197.68.763E-70.016253gtex_brain_ba24
rs61917956127348659PEX5ENSG00000139197.64.544E-70.017378gtex_brain_ba24
rs78613188127348728PEX5ENSG00000139197.69.674E-80.017447gtex_brain_ba24
rs200498082127348907PEX5ENSG00000139197.61.518E-70.017626gtex_brain_ba24
rs61917957127349987PEX5ENSG00000139197.67.538E-70.018706gtex_brain_ba24
rs200609395127350135PEX5ENSG00000139197.67.415E-80.018854gtex_brain_ba24
rs185073397127350136PEX5ENSG00000139197.65.77E-70.018855gtex_brain_ba24
rs7139158127350155PEX5ENSG00000139197.61.011E-70.018874gtex_brain_ba24
rs7962563127353514PEX5ENSG00000139197.68.647E-70.0112233gtex_brain_ba24
rs10743271127353790PEX5ENSG00000139197.61.326E-70.0112509gtex_brain_ba24
rs7315553127353838PEX5ENSG00000139197.68.667E-70.0112557gtex_brain_ba24
rs12825629127355583PEX5ENSG00000139197.68.702E-70.0114302gtex_brain_ba24
rs6486910127356479PEX5ENSG00000139197.63.866E-70.0115198gtex_brain_ba24
rs6486911127356494PEX5ENSG00000139197.63.874E-70.0115213gtex_brain_ba24
rs7970916127357746PEX5ENSG00000139197.68.763E-70.0116465gtex_brain_ba24
rs75912799127357897PEX5ENSG00000139197.68.763E-70.0116616gtex_brain_ba24
rs10161405127358646PEX5ENSG00000139197.63.071E-70.0117365gtex_brain_ba24
rs10161542127358684PEX5ENSG00000139197.63.071E-70.0117403gtex_brain_ba24
rs11044332127358768PEX5ENSG00000139197.68.763E-70.0117487gtex_brain_ba24
rs111408486127359175PEX5ENSG00000139197.68.763E-70.0117894gtex_brain_ba24
rs397737333127359309PEX5ENSG00000139197.68.763E-70.0118028gtex_brain_ba24
rs3825405127360143PEX5ENSG00000139197.68.763E-70.0118862gtex_brain_ba24
rs3816424127360229PEX5ENSG00000139197.61.42E-70.0118948gtex_brain_ba24
rs1057225127363574PEX5ENSG00000139197.68.763E-70.0122293gtex_brain_ba24
rs11448434127363943PEX5ENSG00000139197.61.015E-80.0122662gtex_brain_ba24
rs4329748127364442PEX5ENSG00000139197.68.763E-70.0123161gtex_brain_ba24
rs4492891127364789PEX5ENSG00000139197.61.497E-60.0123508gtex_brain_ba24
rs200081407127366581PEX5ENSG00000139197.68.857E-70.0125300gtex_brain_ba24
rs12228393127368182PEX5ENSG00000139197.68.763E-70.0126901gtex_brain_ba24
rs10161170127368629PEX5ENSG00000139197.61.422E-70.0127348gtex_brain_ba24
rs11044901127368691PEX5ENSG00000139197.61.413E-70.0127410gtex_brain_ba24
rs10161103127369087PEX5ENSG00000139197.61.42E-70.0127806gtex_brain_ba24
rs7969508127370502PEX5ENSG00000139197.61.427E-70.0129221gtex_brain_ba24
rs7969635127370612PEX5ENSG00000139197.61.427E-70.0129331gtex_brain_ba24
rs7969751127370702PEX5ENSG00000139197.61.423E-70.0129421gtex_brain_ba24
rs7962917127317194PEX5ENSG00000139197.61.276E-80-24087gtex_brain_putamen_basal
rs1450962127320545PEX5ENSG00000139197.62.133E-100-20736gtex_brain_putamen_basal
rs12828040127326541PEX5ENSG00000139197.61.997E-100-14740gtex_brain_putamen_basal
rs7310539127329996PEX5ENSG00000139197.62.435E-100-11285gtex_brain_putamen_basal
rs111377129127331606PEX5ENSG00000139197.61.413E-60-9675gtex_brain_putamen_basal
rs1839622127334534PEX5ENSG00000139197.62.247E-100-6747gtex_brain_putamen_basal
rs7973719127334813PEX5ENSG00000139197.66.325E-100-6468gtex_brain_putamen_basal
rs12828421127335217PEX5ENSG00000139197.62.079E-100-6064gtex_brain_putamen_basal
rs12816419127335420PEX5ENSG00000139197.66.331E-100-5861gtex_brain_putamen_basal
rs397742110127336926PEX5ENSG00000139197.65.252E-100-4355gtex_brain_putamen_basal
rs397851127127338793PEX5ENSG00000139197.69.714E-90-2488gtex_brain_putamen_basal
rs61917955127338947PEX5ENSG00000139197.61.839E-100-2334gtex_brain_putamen_basal
rs12227917127342343PEX5ENSG00000139197.62.655E-1001062gtex_brain_putamen_basal
rs200807978127342364PEX5ENSG00000139197.63.05E-901083gtex_brain_putamen_basal
rs201786247127342367PEX5ENSG00000139197.61.249E-601086gtex_brain_putamen_basal
rs200032511127342371PEX5ENSG00000139197.66.54E-701090gtex_brain_putamen_basal
rs12424618127344802PEX5ENSG00000139197.61.258E-1103521gtex_brain_putamen_basal
rs2053887127346530PEX5ENSG00000139197.64.144E-1205249gtex_brain_putamen_basal
rs12830671127347278PEX5ENSG00000139197.62.807E-1205997gtex_brain_putamen_basal
rs12820829127347534PEX5ENSG00000139197.62.799E-1206253gtex_brain_putamen_basal
rs61917956127348659PEX5ENSG00000139197.63.767E-1207378gtex_brain_putamen_basal
rs78613188127348728PEX5ENSG00000139197.61.218E-1107447gtex_brain_putamen_basal
rs200897876127348841PEX5ENSG00000139197.61.086E-807560gtex_brain_putamen_basal
rs200264446127348912PEX5ENSG00000139197.62.823E-707631gtex_brain_putamen_basal
rs181450002127349108PEX5ENSG00000139197.61.562E-807827gtex_brain_putamen_basal
rs186088555127349135PEX5ENSG00000139197.63.921E-707854gtex_brain_putamen_basal
rs183222544127349162PEX5ENSG00000139197.61.979E-907881gtex_brain_putamen_basal
rs61917957127349987PEX5ENSG00000139197.62.169E-908706gtex_brain_putamen_basal
rs71067161127350013PEX5ENSG00000139197.67.964E-1008732gtex_brain_putamen_basal
rs117028872127350028PEX5ENSG00000139197.61.328E-608747gtex_brain_putamen_basal
rs79081846127350052PEX5ENSG00000139197.69.669E-1008771gtex_brain_putamen_basal
rs200609395127350135PEX5ENSG00000139197.63.462E-808854gtex_brain_putamen_basal
rs185073397127350136PEX5ENSG00000139197.65.01E-708855gtex_brain_putamen_basal
rs7139158127350155PEX5ENSG00000139197.62.458E-808874gtex_brain_putamen_basal
rs78964892127352735PEX5ENSG00000139197.66.008E-10011454gtex_brain_putamen_basal
rs138686752127352903PEX5ENSG00000139197.62.405E-12011622gtex_brain_putamen_basal
rs7973600127353351PEX5ENSG00000139197.66.853E-14012070gtex_brain_putamen_basal
rs7962563127353514PEX5ENSG00000139197.61.329E-13012233gtex_brain_putamen_basal
rs10743271127353790PEX5ENSG00000139197.62.402E-10012509gtex_brain_putamen_basal
rs7315553127353838PEX5ENSG00000139197.61.455E-13012557gtex_brain_putamen_basal
rs12825629127355583PEX5ENSG00000139197.61.005E-13014302gtex_brain_putamen_basal
rs6486910127356479PEX5ENSG00000139197.61.906E-13015198gtex_brain_putamen_basal
rs6486911127356494PEX5ENSG00000139197.61.904E-13015213gtex_brain_putamen_basal
rs372666240127356574PEX5ENSG00000139197.61.163E-6015293gtex_brain_putamen_basal
rs7970916127357746PEX5ENSG00000139197.61.449E-13016465gtex_brain_putamen_basal
rs75912799127357897PEX5ENSG00000139197.61.449E-13016616gtex_brain_putamen_basal
rs10161405127358646PEX5ENSG00000139197.65.601E-8017365gtex_brain_putamen_basal
rs10161542127358684PEX5ENSG00000139197.65.601E-8017403gtex_brain_putamen_basal
rs11044332127358768PEX5ENSG00000139197.61.449E-13017487gtex_brain_putamen_basal
rs111408486127359175PEX5ENSG00000139197.61.449E-13017894gtex_brain_putamen_basal
rs397737333127359309PEX5ENSG00000139197.61.449E-13018028gtex_brain_putamen_basal
rs3825405127360143PEX5ENSG00000139197.61.449E-13018862gtex_brain_putamen_basal
rs3816424127360229PEX5ENSG00000139197.66.524E-10018948gtex_brain_putamen_basal
rs1057225127363574PEX5ENSG00000139197.61.449E-13022293gtex_brain_putamen_basal
rs11448434127363943PEX5ENSG00000139197.61.995E-9022662gtex_brain_putamen_basal
rs4329748127364442PEX5ENSG00000139197.61.449E-13023161gtex_brain_putamen_basal
rs4512930127364623PEX5ENSG00000139197.62.205E-13023342gtex_brain_putamen_basal
rs4492891127364789PEX5ENSG00000139197.61.454E-13023508gtex_brain_putamen_basal
rs200081407127366581PEX5ENSG00000139197.61.143E-9025300gtex_brain_putamen_basal
rs12228393127368182PEX5ENSG00000139197.62.807E-12026901gtex_brain_putamen_basal
rs10161170127368629PEX5ENSG00000139197.66.543E-10027348gtex_brain_putamen_basal
rs11044901127368691PEX5ENSG00000139197.66.612E-10027410gtex_brain_putamen_basal
rs10161103127369087PEX5ENSG00000139197.66.524E-10027806gtex_brain_putamen_basal
rs397830029127369169PEX5ENSG00000139197.61.22E-12027888gtex_brain_putamen_basal
rs6487053127369318PEX5ENSG00000139197.61.275E-12028037gtex_brain_putamen_basal
rs61919598127370116PEX5ENSG00000139197.65.956E-7028835gtex_brain_putamen_basal
rs7969508127370502PEX5ENSG00000139197.67.99E-10029221gtex_brain_putamen_basal
rs7969635127370612PEX5ENSG00000139197.67.99E-10029331gtex_brain_putamen_basal
rs7969751127370702PEX5ENSG00000139197.68E-10029421gtex_brain_putamen_basal
rs72098838127371483PEX5ENSG00000139197.62.216E-7030202gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ATAD10.930.91
SLC30A90.920.91
RAB180.920.92
CUL20.920.89
STX120.920.91
FAM49B0.920.90
USP330.920.90
C10orf880.910.90
PPP2CA0.910.89
CCDC1320.910.89
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.74-0.68
AF347015.33-0.72-0.66
AF347015.8-0.71-0.67
MT-CYB-0.71-0.66
FXYD1-0.71-0.68
AF347015.2-0.71-0.65
AF347015.26-0.71-0.66
HIGD1B-0.69-0.64
AF347015.31-0.69-0.65
AF347015.21-0.69-0.60

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI9653144 |10837480 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001764neuron migrationIEAneuron (GO term level: 8)-
GO:0021895cerebral cortex neuron differentiationIEAneuron, Brain (GO term level: 9)-
GO:0000038very-long-chain fatty acid metabolic processIEA-
GO:0007006mitochondrial membrane organizationIEA-
GO:0048468cell developmentIEA-
GO:0007031peroxisome organizationIEA-
GO:0007029endoplasmic reticulum organizationIEA-
GO:0006635fatty acid beta-oxidationIEA-
GO:0015031protein transportIEA-
GO:0040018positive regulation of multicellular organism growthIEA-
GO:0021795cerebral cortex cell migrationIEA-
GO:0044255cellular lipid metabolic processIEA-
GO:0050905neuromuscular processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0005777peroxisomeIEA-
GO:0005778peroxisomal membraneIEA-
GO:0016020membraneIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutated-HPRD,BioGRID10567403 
CATMGC138422 | MGC138424catalaseTwo-hybridBioGRID10567403 
DDODASOX | DDO-1 | DDO-2 | FLJ45203D-aspartate oxidase-HPRD,BioGRID9820813 
HSPA1AFLJ54303 | FLJ54370 | FLJ54392 | FLJ54408 | FLJ75127 | HSP70-1 | HSP70-1A | HSP70I | HSP72 | HSPA1 | HSPA1Bheat shock 70kDa protein 1A-HPRD11415446 
PDZK1CAP70 | CLAMP | NHERF3 | PDZD1PDZ domain containing 1Two-hybridBioGRID16189514 
PEX10MGC1998 | NALD | RNF69peroxisomal biogenesis factor 10-HPRD,BioGRID10837480 
PEX12PAF-3peroxisomal biogenesis factor 12PEX12 interacts with PEX5.BIND12096124 
PEX12PAF-3peroxisomal biogenesis factor 12-HPRD,BioGRID10562279 |10837480 
PEX13NALD | ZWSperoxisomal biogenesis factor 13-HPRD,BioGRID8858165 |11865044 
PEX14MGC12767 | NAPP2 | Pex14p | dJ734G22.2peroxisomal biogenesis factor 14PEX14 interacts with PEX5.BIND12096124 
PEX14MGC12767 | NAPP2 | Pex14p | dJ734G22.2peroxisomal biogenesis factor 14Reconstituted Complex
Two-hybrid
BioGRID10212238 |10837480 
|11865044 
PEX14MGC12767 | NAPP2 | Pex14p | dJ734G22.2peroxisomal biogenesis factor 14-HPRD10212238 |11865044 
PEX7PTS2R | RCDP1 | RDperoxisomal biogenesis factor 7-HPRD,BioGRID11546814 |11865044 
PXMP3PAF-1 | PAF1 | PEX2 | PMP3 | PMP35 | RNF72peroxisomal membrane protein 3, 35kDa-HPRD10837480 
SIRT3SIR2L3sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)Two-hybridBioGRID16189514 
SNUPNKPNBL | RNUT1 | Snurportin1snurportin 1Two-hybridBioGRID16169070 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PEROXISOME 7847All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526357All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN 241146All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED DN 8647All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP 13378All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 14789All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 10173All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514330All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
ZHAN V2 LATE DIFFERENTIATION GENES 4534All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION MUSCLE UP 4333All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
YOSHIOKA LIVER CANCER EARLY RECURRENCE UP 4023All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS UP 8451All SZGR 2.0 genes in this pathway
TERAO AOX4 TARGETS HG UP 2820All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND WITH H4K20ME1 MARK 14582All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS 239156All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-141/200a9199261A,m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-15/16/195/424/497272278m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-29269275m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-318928991A,m8hsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-361330336m8hsa-miR-361brainUUAUCAGAAUCUCCAGGGGUAC