Gene Page: RELB
Summary ?
| GeneID | 5971 |
| Symbol | RELB |
| Synonyms | I-REL|IREL|REL-B |
| Description | v-rel avian reticuloendotheliosis viral oncogene homolog B |
| Reference | MIM:604758|HGNC:HGNC:9956|Ensembl:ENSG00000104856|HPRD:06886|Vega:OTTHUMG00000162116 |
| Gene type | protein-coding |
| Map location | 19q13.32 |
| Pascal p-value | 8.964E-4 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.009 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003700 | transcription factor activity | TAS | 8188306 | |
| GO:0003714 | transcription corepressor activity | TAS | 1577270 | |
| GO:0005515 | protein binding | IPI | 15799966 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0043011 | myeloid dendritic cell differentiation | IEA | dendrite (GO term level: 10) | - |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | - | |
| GO:0019882 | antigen processing and presentation | IEA | - | |
| GO:0045063 | T-helper 1 cell differentiation | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ACTL6A | ACTL6 | Arp4 | BAF53A | INO80K | MGC5382 | actin-like 6A | - | HPRD,BioGRID | 14743216 |
| AKAP8L | DKFZp434L0650 | HA95 | HAP95 | NAKAP | NAKAP95 | A kinase (PRKA) anchor protein 8-like | - | HPRD | 14743216 |
| ARID1A | B120 | BAF250 | BAF250a | BM029 | C1orf4 | P270 | SMARCF1 | AT rich interactive domain 1A (SWI-like) | - | HPRD | 14743216 |
| ARID1B | 6A3-5 | BAF250b | BRIGHT | DAN15 | ELD/OSA1 | KIAA1235 | p250R | AT rich interactive domain 1B (SWI1-like) | - | HPRD | 14743216 |
| BCL3 | BCL4 | D19S37 | B-cell CLL/lymphoma 3 | Co-localization | BioGRID | 14678988 |
| BCL7A | BCL7 | B-cell CLL/lymphoma 7A | Affinity Capture-MS | BioGRID | 14743216 |
| DPF2 | MGC10180 | REQ | UBID4 | ubi-d4 | D4, zinc and double PHD fingers family 2 | Affinity Capture-MS | BioGRID | 14743216 |
| DSP | DPI | DPII | desmoplakin | - | HPRD | 14743216 |
| HDAC6 | FLJ16239 | HD6 | JM21 | histone deacetylase 6 | Affinity Capture-MS | BioGRID | 14743216 |
| HSPA8 | HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71 | heat shock 70kDa protein 8 | - | HPRD | 14743216 |
| KPNA2 | IPOA1 | QIP2 | RCH1 | SRP1alpha | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | Affinity Capture-MS | BioGRID | 14743216 |
| KPNA6 | FLJ11249 | IPOA7 | KPNA7 | MGC17918 | karyopherin alpha 6 (importin alpha 7) | Affinity Capture-MS | BioGRID | 14743216 |
| NFKB1 | DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Affinity Capture-MS | BioGRID | 14743216 |
| NFKB2 | LYT-10 | LYT10 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | Affinity Capture-MS Co-localization | BioGRID | 14678988 |14743216 |
| NFKB2 | LYT-10 | LYT10 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | - | HPRD | 12505990 |
| RELA | MGC131774 | NFKB3 | p65 | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Affinity Capture-MS | BioGRID | 14743216 |
| SMARCA4 | BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2b | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | Affinity Capture-MS | BioGRID | 14743216 |
| SMARCB1 | BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFS | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | Affinity Capture-MS | BioGRID | 14743216 |
| SMARCC1 | BAF155 | CRACC1 | Rsc8 | SRG3 | SWI3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | Affinity Capture-MS | BioGRID | 14743216 |
| SMARCC2 | BAF170 | CRACC2 | Rsc8 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | - | HPRD,BioGRID | 14743216 |
| SMARCE1 | BAF57 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | Affinity Capture-MS | BioGRID | 14743216 |
| TNIP2 | ABIN-2 | ABIN2 | FLIP1 | KLIP | MGC4289 | TNFAIP3 interacting protein 2 | - | HPRD | 14743216 |
| TUBA3C | TUBA2 | bA408E5.3 | tubulin, alpha 3c | - | HPRD | 14743216 |
| USP11 | UHX1 | ubiquitin specific peptidase 11 | Affinity Capture-MS | BioGRID | 14743216 |
| USP9X | DFFRX | FAF | FAM | ubiquitin specific peptidase 9, X-linked | - | HPRD | 14743216 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG MAPK SIGNALING PATHWAY | 267 | 205 | All SZGR 2.0 genes in this pathway |
| PID IL12 2PATHWAY | 63 | 54 | All SZGR 2.0 genes in this pathway |
| BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP | 206 | 111 | All SZGR 2.0 genes in this pathway |
| GARY CD5 TARGETS UP | 473 | 314 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | All SZGR 2.0 genes in this pathway |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP | 136 | 80 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LPS UP | 431 | 237 | All SZGR 2.0 genes in this pathway |
| KIM WT1 TARGETS UP | 214 | 155 | All SZGR 2.0 genes in this pathway |
| GILMORE CORE NFKB PATHWAY | 14 | 10 | All SZGR 2.0 genes in this pathway |
| ROVERSI GLIOMA COPY NUMBER UP | 100 | 75 | All SZGR 2.0 genes in this pathway |
| RASHI RESPONSE TO IONIZING RADIATION 2 | 127 | 92 | All SZGR 2.0 genes in this pathway |
| RASHI NFKB1 TARGETS | 19 | 18 | All SZGR 2.0 genes in this pathway |
| AMUNDSON RESPONSE TO ARSENITE | 217 | 143 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | All SZGR 2.0 genes in this pathway |
| SCIAN INVERSED TARGETS OF TP53 AND TP73 DN | 31 | 23 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES CORE NINE CORRELATED | 100 | 68 | All SZGR 2.0 genes in this pathway |
| ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP | 223 | 140 | All SZGR 2.0 genes in this pathway |
| TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | All SZGR 2.0 genes in this pathway |
| OKUMURA INFLAMMATORY RESPONSE LPS | 183 | 115 | All SZGR 2.0 genes in this pathway |
| PENG RAPAMYCIN RESPONSE UP | 203 | 130 | All SZGR 2.0 genes in this pathway |
| XU CREBBP TARGETS DN | 44 | 31 | All SZGR 2.0 genes in this pathway |
| MUNSHI MULTIPLE MYELOMA UP | 81 | 52 | All SZGR 2.0 genes in this pathway |
| LEE CALORIE RESTRICTION NEOCORTEX UP | 83 | 66 | All SZGR 2.0 genes in this pathway |
| LEE CALORIE RESTRICTION MUSCLE DN | 51 | 28 | All SZGR 2.0 genes in this pathway |
| HUANG FOXA2 TARGETS UP | 45 | 28 | All SZGR 2.0 genes in this pathway |
| SAGIV CD24 TARGETS DN | 46 | 26 | All SZGR 2.0 genes in this pathway |
| GAURNIER PSMD4 TARGETS | 73 | 55 | All SZGR 2.0 genes in this pathway |
| CHEN HOXA5 TARGETS 9HR UP | 223 | 132 | All SZGR 2.0 genes in this pathway |
| QI PLASMACYTOMA UP | 259 | 185 | All SZGR 2.0 genes in this pathway |
| CUI GLUCOSE DEPRIVATION | 60 | 44 | All SZGR 2.0 genes in this pathway |
| BLUM RESPONSE TO SALIRASIB UP | 245 | 159 | All SZGR 2.0 genes in this pathway |
| HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS | 80 | 56 | All SZGR 2.0 genes in this pathway |
| VILIMAS NOTCH1 TARGETS UP | 52 | 41 | All SZGR 2.0 genes in this pathway |
| LINDSTEDT DENDRITIC CELL MATURATION B | 53 | 36 | All SZGR 2.0 genes in this pathway |
| MARSHALL VIRAL INFECTION RESPONSE DN | 29 | 21 | All SZGR 2.0 genes in this pathway |
| SWEET LUNG CANCER KRAS UP | 491 | 316 | All SZGR 2.0 genes in this pathway |
| HINATA NFKB TARGETS FIBROBLAST UP | 84 | 60 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| COULOUARN TEMPORAL TGFB1 SIGNATURE DN | 138 | 99 | All SZGR 2.0 genes in this pathway |
| TIAN TNF SIGNALING VIA NFKB | 28 | 21 | All SZGR 2.0 genes in this pathway |
| WONG ADULT TISSUE STEM MODULE | 721 | 492 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13 | 172 | 107 | All SZGR 2.0 genes in this pathway |
| VERHAAK GLIOBLASTOMA MESENCHYMAL | 216 | 130 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
| PEDRIOLI MIR31 TARGETS DN | 418 | 245 | All SZGR 2.0 genes in this pathway |
| PHONG TNF RESPONSE NOT VIA P38 | 337 | 236 | All SZGR 2.0 genes in this pathway |
| ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION | 128 | 81 | All SZGR 2.0 genes in this pathway |
| GHANDHI DIRECT IRRADIATION UP | 110 | 68 | All SZGR 2.0 genes in this pathway |
| GHANDHI BYSTANDER IRRADIATION UP | 86 | 54 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |