Gene Page: RFNG

Summary ?
GeneID5986
SymbolRFNG
Synonyms-
DescriptionRFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
ReferenceMIM:602578|HGNC:HGNC:9974|Ensembl:ENSG00000169733|HPRD:09093|Vega:OTTHUMG00000178512
Gene typeprotein-coding
Map location17q25
Pascal p-value0.045
eGeneCerebellar Hemisphere
Cerebellum

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TOP2B0.970.97
DHX570.960.96
ZNF2920.960.97
ZNF840.960.97
CNOT20.960.95
DHX290.960.97
ZNF6440.960.96
WDR30.950.96
SF3B10.950.96
SUPT16H0.950.96
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.77-0.92
HLA-F-0.76-0.82
AIFM3-0.76-0.82
AF347015.27-0.75-0.89
MT-CO2-0.75-0.92
AF347015.33-0.75-0.89
TSC22D4-0.74-0.83
FXYD1-0.74-0.90
IFI27-0.74-0.90
S100B-0.74-0.84

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
GO:0016757transferase activity, transferring glycosyl groupsIEA-
GO:0033829O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0009887organ morphogenesisNAS10341080 
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000139Golgi membraneIEA-
GO:0005794Golgi apparatusIEA-
GO:0005576extracellular regionNAS10341080 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NOTCH SIGNALING PATHWAY 4735All SZGR 2.0 genes in this pathway
REACTOME PRE NOTCH EXPRESSION AND PROCESSING 4424All SZGR 2.0 genes in this pathway
REACTOME PRE NOTCH PROCESSING IN GOLGI 1610All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH 10364All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276187All SZGR 2.0 genes in this pathway
BOGNI TREATMENT RELATED MYELOID LEUKEMIA UP 3019All SZGR 2.0 genes in this pathway
MAYBURD RESPONSE TO L663536 UP 2918All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 UP 5734All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290172All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 2 3023All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN 264168All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 12081All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K9ME3 UP 14175All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway