Gene Page: TRIM27

Summary ?
GeneID5987
SymbolTRIM27
SynonymsRFP|RNF76
Descriptiontripartite motif containing 27
ReferenceMIM:602165|HGNC:HGNC:9975|Ensembl:ENSG00000204713|HPRD:15996|Vega:OTTHUMG00000031215
Gene typeprotein-coding
Map location6p22
Pascal p-value1E-12
Sherlock p-value0.72
Fetal beta0.756
DMG2 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3
GSMA_IGenome scan meta-analysisPsr: 0.033 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg11629443628891340TRIM271.53E-5-0.5120.015DMG:Wockner_2014
cg26135345628806907TRIM274.18E-9-0.0162.51E-6DMG:Jaffe_2016
cg10162774628864168TRIM273.33E-8-0.0199.98E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
snp_a-18569930TRIM2759870.18trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PDLIM30.520.43
PECI0.500.44
CD990.500.35
DBI0.490.43
NUP370.470.35
SNRPG0.460.31
TEX90.460.21
EFNA40.450.35
CLIC10.450.34
RAB320.450.30
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NDRG1-0.35-0.40
SLCO3A1-0.35-0.37
AC016910.1-0.35-0.39
DOCK9-0.35-0.34
C1orf115-0.34-0.39
KIF16B-0.34-0.30
SPTBN2-0.33-0.34
RHOU-0.33-0.37
SPTBN1-0.33-0.32
DUSP7-0.33-0.35

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004714transmembrane receptor protein tyrosine kinase activityTASneurite (GO term level: 8)3078962 
GO:0003677DNA bindingIEA-
GO:0005515protein bindingIPI9570750 |15837424 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingTAS3380101 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA10976108 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0007283spermatogenesisTAS3380101 
GO:0008283cell proliferationTAS2734021 
GO:0045814negative regulation of gene expression, epigeneticIDA10976108 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005624membrane fractionTAS3078962 
GO:0005634nucleusIEA-
GO:0005654nucleoplasmIDA10976108 
GO:0005737cytoplasmIEA-
GO:0005887integral to plasma membraneTAS3078962 
GO:0031965nuclear membraneIDA10976108 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BEGAINKIAA1446brain-enriched guanylate kinase-associated homolog (rat)Two-hybridBioGRID16189514 
CHD4DKFZp686E06161 | Mi-2b | Mi2-BETAchromodomain helicase DNA binding protein 4-HPRD14530259 
DNMT1AIM | CXXC9 | DNMT | FLJ16293 | MCMT | MGC104992DNA (cytosine-5-)-methyltransferase 1Two-hybridBioGRID16169070 
EIF3EEIF3-P48 | EIF3S6 | INT6 | eIF3-p46eukaryotic translation initiation factor 3, subunit E-HPRD10504338 
EPC1DKFZp781P2312 | Epl1enhancer of polycomb homolog 1 (Drosophila)-HPRD10976108 
FBF1Alb | FBF-1 | FLJ00103Fas (TNFRSF6) binding factor 1Two-hybridBioGRID16189514 
FXYD6-FXYD domain containing ion transport regulator 6Two-hybridBioGRID16169070 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD14530259 
MAGEA11MAGE-11 | MAGE11 | MAGEA-11 | MGC10511melanoma antigen family A, 11Two-hybridBioGRID16189514 
MCOLN1ML4 | MLIV | MST080 | MSTP080 | TRP-ML1 | TRPM-L1 | TRPML1mucolipin 1Two-hybridBioGRID16169070 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD,BioGRID9570750 
PRAM1MGC39864 | PRAM-1PML-RARA regulated adaptor molecule 1Affinity Capture-Western
Two-hybrid		BioGRID9570750 
TRIM11BIA1 | RNF92tripartite motif-containing 11-HPRD,BioGRID11331580 
TRIM23ARD1 | ARFD1 | RNF46tripartite motif-containing 23-HPRD,BioGRID11331580 
TRIM27RFP | RNF76tripartite motif-containing 27Two-hybridBioGRID11331580 
TRIM29ATDC | FLJ36085tripartite motif-containing 29-HPRD,BioGRID11331580 
TRIM32BBS11 | HT2A | LGMD2H | TATIPtripartite motif-containing 32-HPRD,BioGRID11331580 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16Two-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
CASORELLI APL SECONDARY VS DE NOVO UP 3925All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 7751All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS 5845All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP 176111All SZGR 2.0 genes in this pathway
TOMLINS PROSTATE CANCER UP 4027All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287208All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
HOWLIN CITED1 TARGETS 2 UP 1710All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491310All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G 17196All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BAKKER FOXO3 TARGETS DN 187109All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL DN 14688All SZGR 2.0 genes in this pathway