Gene Page: RPL36AL
Summary ?
| GeneID | 6166 |
| Symbol | RPL36AL |
| Synonyms | RPL36A |
| Description | ribosomal protein L36a like |
| Reference | MIM:180469|HGNC:HGNC:10346|HPRD:01597|Vega:OTTHUMG00000152330 |
| Gene type | protein-coding |
| Map location | 14q21 |
| Pascal p-value | 0.002 |
| Sherlock p-value | 0.4 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4900925 | chr14 | 50012324 | RPL36AL | 6166 | 0.07 | cis | ||
| rs4900928 | chr14 | 50020816 | RPL36AL | 6166 | 0.18 | cis | ||
| rs2985697 | chr14 | 50092901 | RPL36AL | 6166 | 0.03 | cis | ||
| rs4902421 | chr14 | 66299435 | RPL36AL | 6166 | 0.18 | trans | ||
| rs72380805 | 14 | 50077007 | RPL36AL | ENSG00000165502.6 | 3.262E-6 | 0.02 | 10396 | gtex_brain_ba24 |
| rs112308201 | 14 | 50090812 | RPL36AL | ENSG00000165502.6 | 2.817E-6 | 0.02 | -3409 | gtex_brain_ba24 |
| rs10136571 | 14 | 50863560 | RPL36AL | ENSG00000165502.6 | 9.035E-7 | 0.02 | -776157 | gtex_brain_ba24 |
| rs8015368 | 14 | 50020510 | RPL36AL | ENSG00000165502.6 | 2.088E-6 | 0 | 66893 | gtex_brain_putamen_basal |
| rs4900929 | 14 | 50022600 | RPL36AL | ENSG00000165502.6 | 8.242E-7 | 0 | 64803 | gtex_brain_putamen_basal |
| rs1957979 | 14 | 50063332 | RPL36AL | ENSG00000165502.6 | 4.499E-6 | 0 | 24071 | gtex_brain_putamen_basal |
| rs7161649 | 14 | 50064028 | RPL36AL | ENSG00000165502.6 | 4.499E-6 | 0 | 23375 | gtex_brain_putamen_basal |
| rs192623780 | 14 | 50066542 | RPL36AL | ENSG00000165502.6 | 3.458E-6 | 0 | 20861 | gtex_brain_putamen_basal |
| rs200898470 | 14 | 50070229 | RPL36AL | ENSG00000165502.6 | 1.538E-6 | 0 | 17174 | gtex_brain_putamen_basal |
| rs201466061 | 14 | 50070242 | RPL36AL | ENSG00000165502.6 | 1.608E-6 | 0 | 17161 | gtex_brain_putamen_basal |
| rs201572159 | 14 | 50070243 | RPL36AL | ENSG00000165502.6 | 2.116E-6 | 0 | 17160 | gtex_brain_putamen_basal |
| rs1952013 | 14 | 50087357 | RPL36AL | ENSG00000165502.6 | 5.081E-8 | 0 | 46 | gtex_brain_putamen_basal |
| rs1957977 | 14 | 50090603 | RPL36AL | ENSG00000165502.6 | 2.764E-8 | 0 | -3200 | gtex_brain_putamen_basal |
| rs112308201 | 14 | 50090812 | RPL36AL | ENSG00000165502.6 | 5.954E-7 | 0 | -3409 | gtex_brain_putamen_basal |
| rs2147712 | 14 | 50091684 | RPL36AL | ENSG00000165502.6 | 2.443E-8 | 0 | -4281 | gtex_brain_putamen_basal |
| rs12160 | 14 | 50091932 | RPL36AL | ENSG00000165502.6 | 2.511E-8 | 0 | -4529 | gtex_brain_putamen_basal |
| rs2985697 | 14 | 50092902 | RPL36AL | ENSG00000165502.6 | 2.25E-8 | 0 | -5499 | gtex_brain_putamen_basal |
| rs3007041 | 14 | 50094430 | RPL36AL | ENSG00000165502.6 | 2.469E-8 | 0 | -7027 | gtex_brain_putamen_basal |
| rs2985696 | 14 | 50094913 | RPL36AL | ENSG00000165502.6 | 2.55E-8 | 0 | -7510 | gtex_brain_putamen_basal |
| rs3007042 | 14 | 50095335 | RPL36AL | ENSG00000165502.6 | 3.516E-8 | 0 | -7932 | gtex_brain_putamen_basal |
| rs2224949 | 14 | 50096560 | RPL36AL | ENSG00000165502.6 | 2.206E-7 | 0 | -9157 | gtex_brain_putamen_basal |
| rs2209417 | 14 | 50096859 | RPL36AL | ENSG00000165502.6 | 2.113E-7 | 0 | -9456 | gtex_brain_putamen_basal |
| rs17121651 | 14 | 50097172 | RPL36AL | ENSG00000165502.6 | 2.207E-7 | 0 | -9769 | gtex_brain_putamen_basal |
| rs57119148 | 14 | 50097226 | RPL36AL | ENSG00000165502.6 | 1.714E-7 | 0 | -9823 | gtex_brain_putamen_basal |
| rs7142457 | 14 | 50097862 | RPL36AL | ENSG00000165502.6 | 2.176E-7 | 0 | -10459 | gtex_brain_putamen_basal |
| rs2354448 | 14 | 50098296 | RPL36AL | ENSG00000165502.6 | 2.207E-7 | 0 | -10893 | gtex_brain_putamen_basal |
| rs1952012 | 14 | 50098896 | RPL36AL | ENSG00000165502.6 | 2.206E-7 | 0 | -11493 | gtex_brain_putamen_basal |
| rs11299236 | 14 | 50099417 | RPL36AL | ENSG00000165502.6 | 8.605E-7 | 0 | -12014 | gtex_brain_putamen_basal |
| rs2985687 | 14 | 50100386 | RPL36AL | ENSG00000165502.6 | 2.209E-7 | 0 | -12983 | gtex_brain_putamen_basal |
| rs2985686 | 14 | 50100683 | RPL36AL | ENSG00000165502.6 | 7.018E-7 | 0 | -13280 | gtex_brain_putamen_basal |
| rs2985685 | 14 | 50101370 | RPL36AL | ENSG00000165502.6 | 2.21E-7 | 0 | -13967 | gtex_brain_putamen_basal |
| rs2985684 | 14 | 50101682 | RPL36AL | ENSG00000165502.6 | 2.21E-7 | 0 | -14279 | gtex_brain_putamen_basal |
| rs3007031 | 14 | 50102269 | RPL36AL | ENSG00000165502.6 | 2.214E-7 | 0 | -14866 | gtex_brain_putamen_basal |
| rs55782144 | 14 | 50102527 | RPL36AL | ENSG00000165502.6 | 1.555E-7 | 0 | -15124 | gtex_brain_putamen_basal |
| rs12879185 | 14 | 50102595 | RPL36AL | ENSG00000165502.6 | 1.13E-7 | 0 | -15192 | gtex_brain_putamen_basal |
| rs12879350 | 14 | 50102673 | RPL36AL | ENSG00000165502.6 | 1.596E-7 | 0 | -15270 | gtex_brain_putamen_basal |
| rs3007033 | 14 | 50103816 | RPL36AL | ENSG00000165502.6 | 6.36E-7 | 0 | -16413 | gtex_brain_putamen_basal |
| rs11157696 | 14 | 50105746 | RPL36AL | ENSG00000165502.6 | 6.048E-7 | 0 | -18343 | gtex_brain_putamen_basal |
| rs56098064 | 14 | 50105849 | RPL36AL | ENSG00000165502.6 | 3.268E-7 | 0 | -18446 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CHKB | 0.85 | 0.83 |
| ADCK5 | 0.84 | 0.83 |
| RFNG | 0.83 | 0.83 |
| CCDC130 | 0.83 | 0.82 |
| NCAPH2 | 0.82 | 0.82 |
| C16orf68 | 0.81 | 0.79 |
| TRMT2A | 0.81 | 0.79 |
| ZBTB48 | 0.81 | 0.83 |
| MTG1 | 0.81 | 0.82 |
| APBA3 | 0.80 | 0.78 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.27 | -0.55 | -0.59 |
| MT-CYB | -0.54 | -0.58 |
| AF347015.8 | -0.53 | -0.57 |
| AF347015.15 | -0.53 | -0.58 |
| ABCG2 | -0.53 | -0.56 |
| AF347015.31 | -0.52 | -0.55 |
| AF347015.2 | -0.51 | -0.56 |
| MT-ATP8 | -0.51 | -0.62 |
| MT-CO2 | -0.51 | -0.54 |
| AF347015.33 | -0.51 | -0.56 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG RIBOSOME | 88 | 43 | All SZGR 2.0 genes in this pathway |
| HOLLMANN APOPTOSIS VIA CD40 DN | 267 | 178 | All SZGR 2.0 genes in this pathway |
| ONKEN UVEAL MELANOMA DN | 526 | 357 | All SZGR 2.0 genes in this pathway |
| LAIHO COLORECTAL CANCER SERRATED UP | 112 | 71 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 3 DN | 229 | 142 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP | 555 | 346 | All SZGR 2.0 genes in this pathway |
| KAYO AGING MUSCLE DN | 123 | 76 | All SZGR 2.0 genes in this pathway |
| HILLION HMGA1 TARGETS | 90 | 71 | All SZGR 2.0 genes in this pathway |
| ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN | 354 | 216 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |
| MALONEY RESPONSE TO 17AAG DN | 79 | 45 | All SZGR 2.0 genes in this pathway |
| NUTT GBM VS AO GLIOMA DN | 45 | 22 | All SZGR 2.0 genes in this pathway |
| HSIAO HOUSEKEEPING GENES | 389 | 245 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP | 756 | 494 | All SZGR 2.0 genes in this pathway |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP | 682 | 440 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS LOW SERUM | 100 | 51 | All SZGR 2.0 genes in this pathway |
| BILANGES RAPAMYCIN SENSITIVE VIA TSC1 AND TSC2 | 73 | 37 | All SZGR 2.0 genes in this pathway |
| KRIEG KDM3A TARGETS NOT HYPOXIA | 208 | 107 | All SZGR 2.0 genes in this pathway |
| BOUDOUKHA BOUND BY IGF2BP2 | 111 | 59 | All SZGR 2.0 genes in this pathway |
| PECE MAMMARY STEM CELL UP | 146 | 75 | All SZGR 2.0 genes in this pathway |