Gene Page: SHOX
Summary ?
| GeneID | 6473 |
| Symbol | SHOX |
| Synonyms | GCFX|PHOG|SHOXY|SS |
| Description | short stature homeobox |
| Reference | MIM:312865|MIM:400020|HGNC:HGNC:10853|Ensembl:ENSG00000185960|HPRD:02430| |
| Gene type | protein-coding |
| Map location | Xp22.33;Yp11.3 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NLGN3 | 0.77 | 0.81 |
| PCDHGA12 | 0.77 | 0.82 |
| PCDHGB8P | 0.76 | 0.81 |
| DHCR7 | 0.76 | 0.79 |
| DAG1 | 0.75 | 0.85 |
| SLC7A5 | 0.74 | 0.75 |
| C5orf33 | 0.73 | 0.72 |
| ERLIN2 | 0.73 | 0.73 |
| ADCYAP1R1 | 0.71 | 0.82 |
| PYGB | 0.71 | 0.71 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.54 | -0.58 |
| MT-CO2 | -0.50 | -0.54 |
| AC098691.2 | -0.48 | -0.52 |
| MYL3 | -0.46 | -0.44 |
| AF347015.27 | -0.46 | -0.50 |
| NOSTRIN | -0.46 | -0.46 |
| AL050337.1 | -0.46 | -0.48 |
| AF347015.8 | -0.46 | -0.50 |
| AF347015.31 | -0.46 | -0.51 |
| SYCP3 | -0.45 | -0.47 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| BENPORATH PRC2 TARGETS | 652 | 441 | All SZGR 2.0 genes in this pathway |
| BANDRES RESPONSE TO CARMUSTIN WITHOUT MGMT 48HR DN | 32 | 25 | All SZGR 2.0 genes in this pathway |
| BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN | 161 | 105 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |