Summary ?
GeneID6500
SymbolSKP1
SynonymsEMC19|OCP-II|OCP2|SKP1A|TCEB1L|p19A
DescriptionS-phase kinase-associated protein 1
ReferenceMIM:601434|HGNC:HGNC:10899|HPRD:03255|
Gene typeprotein-coding
Map location5q31
Pascal p-value0.538
Sherlock p-value0.099
Fetal beta0.251
DMG1 (# studies)
eGeneMyers' cis & trans
Meta
SupportINTRACELLULAR SIGNAL TRANSDUCTION

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
ExpressionMeta-analysis of gene expressionP value: 1.419 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg027174865133512833SKP14.8E-6-0.3390.01DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1570589chr9116874354SKP165000.15trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RPS6KA10.730.80
TMEM1890.710.78
LAMP10.700.81
PLOD30.690.74
C14orf490.690.66
CHST60.670.62
PRR5L0.670.69
CD820.670.63
GAL3ST10.670.58
LITAF0.660.71
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CLEC2B-0.30-0.27
SYCP3-0.30-0.40
AP000679.1-0.29-0.29
PLAC9-0.29-0.29
CARD16-0.28-0.23
FAM159B-0.27-0.44
GNG11-0.27-0.31
NOX1-0.27-0.30
IL32-0.27-0.36
RPL9-0.26-0.33

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI14685242 |15070733 |17274640 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0008150biological_processND-
GO:0051437positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP12791267 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9660940 |12820959 |15469984 
GO:0005575cellular_componentND-
GO:0005654nucleoplasmEXP11231585 
GO:0019005SCF ubiquitin ligase complexIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BTRCBETA-TRCP | FBW1A | FBXW1 | FBXW1A | FWD1 | MGC4643 | bTrCP | bTrCP1 | betaTrCPbeta-transducin repeat containingAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID9660940 |10531035 
|10644755 |10918611 
|12609982 
BTRCBETA-TRCP | FBW1A | FBXW1 | FBXW1A | FWD1 | MGC4643 | bTrCP | bTrCP1 | betaTrCPbeta-transducin repeat containingSkp1 interacts with Fbw1a.BIND10531035 
CACYBPGIG5 | MGC87971 | PNAS-107 | RP1-102G20.6 | S100A6BP | SIPcalcyclin binding protein-HPRD,BioGRID11389839 
CCNA2CCN1 | CCNAcyclin A2-HPRD,BioGRID9858587 
CDCA3GRCC8 | MGC2577 | TOME-1cell division cycle associated 3-HPRD,BioGRID12679038 
CDK9C-2k | CDC2L4 | CTK1 | PITALRE | TAKcyclin-dependent kinase 9Affinity Capture-Western
Reconstituted Complex
BioGRID11689688 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAffinity Capture-WesternBioGRID11389839 
CUL1MGC149834 | MGC149835cullin 1-HPRD9827542 
CUL1MGC149834 | MGC149835cullin 1Affinity Capture-WesternBioGRID9430629 |12609982 
|12628165 
CUL1MGC149834 | MGC149835cullin 1SKP1A interacts with Cul1 [15-410] to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex.BIND11961546 
CUL7KIAA0076 | dJ20C7.5cullin 7-HPRD,BioGRID12481031 
FBXL11CXXC8 | DKFZp434M1735 | FBL11 | FBL7 | FLJ00115 | FLJ46431 | JHDM1A | KDM2A | KIAA1004 | LILINAF-box and leucine-rich repeat protein 11An unspecified isoform of SKP1 interacts with FBL11.BIND15070733 
FBXL2DKFZp564P0622 | FBL2 | FBL3F-box and leucine-rich repeat protein 2-HPRD10508920 
FBXL2DKFZp564P0622 | FBL2 | FBL3F-box and leucine-rich repeat protein 2Skp1 interacts with Fbl2.BIND10531037 
FBXL3FBL3 | FBL3A | FBXL3AF-box and leucine-rich repeat protein 3Skp1 interacts with Fbl3aBIND10531035 
FBXL3FBL3 | FBL3A | FBXL3AF-box and leucine-rich repeat protein 3-HPRD,BioGRID10531035 
FBXL4FBL4 | FBL5F-box and leucine-rich repeat protein 4Skp1 interacts with Fbl4.BIND10531037 
FBXL4FBL4 | FBL5F-box and leucine-rich repeat protein 4-HPRD,BioGRID10531037 
FBXL5FBL4 | FBL5 | FLR1F-box and leucine-rich repeat protein 5Skp1 interacts with Fbl5.BIND10531037 
FBXL5FBL4 | FBL5 | FLR1F-box and leucine-rich repeat protein 5-HPRD,BioGRID10531037 
FBXL7FBL6 | FBL7F-box and leucine-rich repeat protein 7An unspecified isoform of SKP1 interacts with FBL7.BIND15070733 
FBXL8FBL8 | FLJ11278 | MGC19959F-box and leucine-rich repeat protein 8-HPRD10531037 
FBXO17FBG4 | FBX26 | FBXO26 | FLJ11798 | FLJ25205 | Fbx17 | MGC9379F-box protein 17-HPRD10531037 
FBXO18FBH1 | FLJ14590 | Fbx18 | MGC131916 | MGC141935 | MGC141937F-box protein, helicase, 18-HPRD,BioGRID11956208 
FBXO18FBH1 | FLJ14590 | Fbx18 | MGC131916 | MGC141935 | MGC141937F-box protein, helicase, 18FBH1 interacts with SKP1.BIND11956208 
FBXO2FBG1 | FBX2 | Fbs1 | NFB42F-box protein 2-HPRD10531035 
FBXO3DKFZp564B092 | FBA | FBX3F-box protein 3Skp1 interacts with Fbx3.BIND10531037 
FBXO32FLJ32424 | Fbx32 | MAFbx | MGC33610F-box protein 32-HPRD,BioGRID11717410 
FBXO34CGI-301 | DKFZp547C162 | FLJ20725 | Fbx34 | MGC126434 | MGC126435F-box protein 34Two-hybridBioGRID16169070 
FBXO4DKFZp547N213 | FBX4 | FLJ10141F-box protein 4Skp1 interacts with Fbx4.BIND10531035 
FBXO4DKFZp547N213 | FBX4 | FLJ10141F-box protein 4-HPRD,BioGRID10531035 
FBXO41FLJ37709 | Fbx41F-box protein 41An unspecified isoform of SKP1 interacts with KIAA1940.BIND15070733 
FBXO44DKFZp781J0852 | FBG3 | FBX30 | FBX6A | Fbx44 | Fbxo6a | MGC14140F-box protein 44-HPRD,BioGRID10531035 
FBXO5EMI1 | FBX5 | Fbxo31F-box protein 5Reconstituted Complex
Two-hybrid
BioGRID10531035 
FBXO5EMI1 | FBX5 | Fbxo31F-box protein 5Skp1 interacts with Fbx5.BIND10531035 
FBXO6FBG2 | FBS2 | FBX6 | Fbx6bF-box protein 6Skp1 interacts with Fbx6a.BIND10531035 
FBXO7DKFZp686B08113 | FBX | FBX07 | FBX7 | PARK15 | PKPSF-box protein 7Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID10531035 
FBXO7DKFZp686B08113 | FBX | FBX07 | FBX7 | PARK15 | PKPSF-box protein 7Skp1 interacts with Fbx7.BIND10531037 
FBXO7DKFZp686B08113 | FBX | FBX07 | FBX7 | PARK15 | PKPSF-box protein 7Skp1 interacts with Fbx7.BIND10531035 
FBXO9DKFZp434C0118 | FBX9 | KIAA0936 | NY-REN-57 | VCIA1 | dJ341E18.2F-box protein 9-HPRD10531035 
FBXW11BTRC2 | BTRCP2 | FBW1B | FBXW1B | Fbw11 | Hos | KIAA0696F-box and WD repeat domain containing 11Affinity Capture-WesternBioGRID10644755 
FBXW2FBW2 | Fwd2 | MGC117371 | Md6F-box and WD repeat domain containing 2Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID10531035 
FBXW2FBW2 | Fwd2 | MGC117371 | Md6F-box and WD repeat domain containing 2Skp1 interacts with Fbw2.BIND10531037 
FBXW2FBW2 | Fwd2 | MGC117371 | Md6F-box and WD repeat domain containing 2Skp1 interacts with Fbw2.BIND10531035 
FBXW2FBW2 | Fwd2 | MGC117371 | Md6F-box and WD repeat domain containing 2An unspecified isoform of SKP1 interacts with FBW2.BIND15070733 
FBXW4P1FBW3 | FBXW3 | SHFM3P1F-box and WD repeat domain containing 4 pseudogene 1An unspecified isoform of SKP1 interacts with FBW3.BIND15070733 
FBXW7AGO | CDC4 | DKFZp686F23254 | FBW6 | FBW7 | FBX30 | FBXO30 | FBXW6 | FLJ16457 | SEL-10 | SEL10F-box and WD repeat domain containing 7-HPRD,BioGRID11585921 
FBXW8FBW6 | FBW8 | FBX29 | FBXO29 | FBXW6 | MGC33534F-box and WD repeat domain containing 8An unspecified isoform of SKP1 interacts with an unspecified isoform of FBW6.BIND15070733 
FBXW8FBW6 | FBW8 | FBX29 | FBXO29 | FBXW6 | MGC33534F-box and WD repeat domain containing 8Affinity Capture-WesternBioGRID12481031 
FBXW8FBW6 | FBW8 | FBX29 | FBXO29 | FBXW6 | MGC33534F-box and WD repeat domain containing 8-HPRD10531037 
GPS1COPS1 | CSN1 | MGC71287G protein pathway suppressor 1-HPRD11337588 
RBX1BA554C12.1 | MGC13357 | MGC1481 | RNF75 | ROC1ring-box 1Affinity Capture-WesternBioGRID12628165 
SIAH1FLJ08065 | HUMSIAH | Siah-1 | Siah-1a | hSIAH1seven in absentia homolog 1 (Drosophila)-HPRD11389839 
SKP2FBL1 | FBXL1 | FLB1 | MGC1366S-phase kinase-associated protein 2 (p45)Skp2-Fbox interacts with SKP1A to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex.BIND11961546 
SKP2FBL1 | FBXL1 | FLB1 | MGC1366S-phase kinase-associated protein 2 (p45)-HPRD9430629 |9827542|11099048 
SKP2FBL1 | FBXL1 | FLB1 | MGC1366S-phase kinase-associated protein 2 (p45)Affinity Capture-Western
Co-crystal Structure
Reconstituted Complex
Two-hybrid
BioGRID9827542 |10531035 
|10559858 |10918611 
|11099048 |12609982 
SUGT1SGT1SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)Reconstituted ComplexBioGRID12746458 
TBK1FLJ11330 | NAK | T2KTANK-binding kinase 1Affinity Capture-MSBioGRID14743216 
TBL1XEBI | SMAP55 | TBL1transducin (beta)-like 1X-linked-HPRD,BioGRID11389839 
ZC3HC11110054L24Rik | HSPC216 | NIPAzinc finger, C3HC-type containing 1NIPA interacts with an unspecified isoform Skp1.BIND16009132 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CELL CYCLE 12884All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS 11479All SZGR 2.0 genes in this pathway
KEGG UBIQUITIN MEDIATED PROTEOLYSIS 13898All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY 151112All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY 8664All SZGR 2.0 genes in this pathway
BIOCARTA SKP2E2F PATHWAY 106All SZGR 2.0 genes in this pathway
BIOCARTA P27 PATHWAY 1310All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY 5949All SZGR 2.0 genes in this pathway
PID BETA CATENIN DEG PATHWAY 1817All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY 8060All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY WNT 6541All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4 9067All SZGR 2.0 genes in this pathway
REACTOME PROLACTIN RECEPTOR SIGNALING 1411All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR SIGNALING BY ERBB4 3830All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 9766All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS 6443All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 12690All SZGR 2.0 genes in this pathway
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 4628All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH1 7046All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325185All SZGR 2.0 genes in this pathway
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 6540All SZGR 2.0 genes in this pathway
REACTOME G1 PHASE 3823All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION 11263All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 13779All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MITOTIC CELL CYCLE 8546All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 10786All SZGR 2.0 genes in this pathway
REACTOME IL1 SIGNALING 3930All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN CLOCK 5340All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH 10364All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 13281All SZGR 2.0 genes in this pathway
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 5132All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251156All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212129All SZGR 2.0 genes in this pathway
REACTOME S PHASE 10966All SZGR 2.0 genes in this pathway
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 5634All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305185All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537339All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST PRENEOPLASTIC UP 2010All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP 15093All SZGR 2.0 genes in this pathway
LUI THYROID CANCER PAX8 PPARG DN 4529All SZGR 2.0 genes in this pathway
LUI TARGETS OF PAX8 PPARG FUSION 3423All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
YANG BREAST CANCER ESR1 BULK UP 2715All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514330All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424268All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL CIS 6538All SZGR 2.0 genes in this pathway
DER IFN ALPHA RESPONSE UP 7448All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN 12179All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP 10267All SZGR 2.0 genes in this pathway
DER IFN GAMMA RESPONSE UP 7145All SZGR 2.0 genes in this pathway
PARK HSC AND MULTIPOTENT PROGENITORS 5033All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP 151103All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS DN 5739All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN UP 7149All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA DN 5233All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN 8858All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP 12375All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX DN 5443All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198128All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN 210128All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 UP 16799All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER BRCA1 DN 4428All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
NIELSEN GIST 9866All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 14583All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP 344215All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784464All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-130/3015056m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-1454204271A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-148/1525157m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-4967557621A,m8hsa-miR-496AUUACAUGGCCAAUCUC
miR-74714781A,m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG