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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SKP1

Summary

GeneID

6500

Symbol

SKP1

Synonyms

EMC19|MGC34403|OCP-II|OCP2|SKP1A|TCEB1L|p19A

Description

S-phase kinase-associated protein 1

Locus tag

Gene type

protein-coding

Map location

5q31

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Expression

P value: 1.419

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

RPS6KA1

0.73

0.80

TMEM189

0.71

0.78

LAMP1

0.70

0.81

PLOD3

0.69

0.74

C14orf49

0.69

0.66

CHST6

0.67

0.62

PRR5L

0.67

0.69

CD82

0.67

0.63

GAL3ST1

0.67

0.58

LITAF

0.66

0.71

Top 10 negatively co-expressed genes

CLEC2B

-0.30

-0.27

SYCP3

-0.30

-0.40

AP000679.1

-0.29

PLAC9

-0.29

CARD16

-0.28

-0.23

FAM159B

-0.27

-0.44

GNG11

-0.27

-0.31

NOX1

-0.27

-0.30

IL32

-0.27

-0.36

RPL9

-0.26

-0.33

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003674

molecular_function

GO:0005515

protein binding

IEA

GO:0005515

protein binding

IPI

14685242 |15070733 |17274640

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006511

ubiquitin-dependent protein catabolic process

IEA

GO:0008150

biological_process

GO:0051437

positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle

EXP

12791267

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005829

cytosol

EXP

9660940 |12820959 |15469984

GO:0005575

cellular_component

GO:0005654

nucleoplasm

EXP

11231585

GO:0019005

SCF ubiquitin ligase complex

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BTRC	BETA-TRCP \| FBW1A \| FBXW1 \| FBXW1A \| FWD1 \| MGC4643 \| bTrCP \| bTrCP1 \| betaTrCP	beta-transducin repeat containing	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9660940 \|10531035 \|10644755 \|10918611 \|12609982
BTRC		beta-transducin repeat containing	Skp1 interacts with Fbw1a.	BIND	10531035
CACYBP	GIG5 \| MGC87971 \| PNAS-107 \| RP1-102G20.6 \| S100A6BP \| SIP	calcyclin binding protein	-	HPRD,BioGRID	11389839
CCNA2	CCN1 \| CCNA	cyclin A2	-	HPRD,BioGRID	9858587
CDCA3	GRCC8 \| MGC2577 \| TOME-1	cell division cycle associated 3	-	HPRD,BioGRID	12679038
CDK9	C-2k \| CDC2L4 \| CTK1 \| PITALRE \| TAK	cyclin-dependent kinase 9	Affinity Capture-Western Reconstituted Complex	BioGRID	11689688
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	Affinity Capture-Western	BioGRID	11389839
CUL1	MGC149834 \| MGC149835	cullin 1	-	HPRD	9827542
			Affinity Capture-Western	BioGRID	9430629 \|12609982 \|12628165
			SKP1A interacts with Cul1 [15-410] to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex.	BIND	11961546
CUL7	KIAA0076 \| dJ20C7.5	cullin 7	-	HPRD,BioGRID	12481031
FBXL11	CXXC8 \| DKFZp434M1735 \| FBL11 \| FBL7 \| FLJ00115 \| FLJ46431 \| JHDM1A \| KDM2A \| KIAA1004 \| LILINA	F-box and leucine-rich repeat protein 11	An unspecified isoform of SKP1 interacts with FBL11.	BIND	15070733
FBXL2	DKFZp564P0622 \| FBL2 \| FBL3	F-box and leucine-rich repeat protein 2	-	HPRD	10508920
FBXL2	DKFZp564P0622 \| FBL2 \| FBL3	F-box and leucine-rich repeat protein 2	Skp1 interacts with Fbl2.	BIND	10531037
FBXL3	FBL3 \| FBL3A \| FBXL3A	F-box and leucine-rich repeat protein 3	Skp1 interacts with Fbl3a	BIND	10531035
FBXL3	FBL3 \| FBL3A \| FBXL3A	F-box and leucine-rich repeat protein 3	-	HPRD,BioGRID	10531035
FBXL4	FBL4 \| FBL5	F-box and leucine-rich repeat protein 4	Skp1 interacts with Fbl4.	BIND	10531037
FBXL4	FBL4 \| FBL5	F-box and leucine-rich repeat protein 4	-	HPRD,BioGRID	10531037
FBXL5	FBL4 \| FBL5 \| FLR1	F-box and leucine-rich repeat protein 5	Skp1 interacts with Fbl5.	BIND	10531037
FBXL5	FBL4 \| FBL5 \| FLR1	F-box and leucine-rich repeat protein 5	-	HPRD,BioGRID	10531037
FBXL7	FBL6 \| FBL7	F-box and leucine-rich repeat protein 7	An unspecified isoform of SKP1 interacts with FBL7.	BIND	15070733
FBXL8	FBL8 \| FLJ11278 \| MGC19959	F-box and leucine-rich repeat protein 8	-	HPRD	10531037
FBXO17	FBG4 \| FBX26 \| FBXO26 \| FLJ11798 \| FLJ25205 \| Fbx17 \| MGC9379	F-box protein 17	-	HPRD	10531037
FBXO18	FBH1 \| FLJ14590 \| Fbx18 \| MGC131916 \| MGC141935 \| MGC141937	F-box protein, helicase, 18	-	HPRD,BioGRID	11956208
FBXO18	FBH1 \| FLJ14590 \| Fbx18 \| MGC131916 \| MGC141935 \| MGC141937	F-box protein, helicase, 18	FBH1 interacts with SKP1.	BIND	11956208
FBXO2	FBG1 \| FBX2 \| Fbs1 \| NFB42	F-box protein 2	-	HPRD	10531035
FBXO3	DKFZp564B092 \| FBA \| FBX3	F-box protein 3	Skp1 interacts with Fbx3.	BIND	10531037
FBXO32	FLJ32424 \| Fbx32 \| MAFbx \| MGC33610	F-box protein 32	-	HPRD,BioGRID	11717410
FBXO34	CGI-301 \| DKFZp547C162 \| FLJ20725 \| Fbx34 \| MGC126434 \| MGC126435	F-box protein 34	Two-hybrid	BioGRID	16169070
FBXO4	DKFZp547N213 \| FBX4 \| FLJ10141	F-box protein 4	Skp1 interacts with Fbx4.	BIND	10531035
FBXO4	DKFZp547N213 \| FBX4 \| FLJ10141	F-box protein 4	-	HPRD,BioGRID	10531035
FBXO41	FLJ37709 \| Fbx41	F-box protein 41	An unspecified isoform of SKP1 interacts with KIAA1940.	BIND	15070733
FBXO44	DKFZp781J0852 \| FBG3 \| FBX30 \| FBX6A \| Fbx44 \| Fbxo6a \| MGC14140	F-box protein 44	-	HPRD,BioGRID	10531035
FBXO5	EMI1 \| FBX5 \| Fbxo31	F-box protein 5	Reconstituted Complex Two-hybrid	BioGRID	10531035
FBXO5	EMI1 \| FBX5 \| Fbxo31	F-box protein 5	Skp1 interacts with Fbx5.	BIND	10531035
FBXO6	FBG2 \| FBS2 \| FBX6 \| Fbx6b	F-box protein 6	Skp1 interacts with Fbx6a.	BIND	10531035
FBXO7	DKFZp686B08113 \| FBX \| FBX07 \| FBX7 \| PARK15 \| PKPS	F-box protein 7	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10531035
			Skp1 interacts with Fbx7.	BIND	10531037
			Skp1 interacts with Fbx7.	BIND	10531035
FBXO9	DKFZp434C0118 \| FBX9 \| KIAA0936 \| NY-REN-57 \| VCIA1 \| dJ341E18.2	F-box protein 9	-	HPRD	10531035
FBXW11	BTRC2 \| BTRCP2 \| FBW1B \| FBXW1B \| Fbw11 \| Hos \| KIAA0696	F-box and WD repeat domain containing 11	Affinity Capture-Western	BioGRID	10644755
FBXW2	FBW2 \| Fwd2 \| MGC117371 \| Md6	F-box and WD repeat domain containing 2	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10531035
			Skp1 interacts with Fbw2.	BIND	10531037
			Skp1 interacts with Fbw2.	BIND	10531035
			An unspecified isoform of SKP1 interacts with FBW2.	BIND	15070733
FBXW4P1	FBW3 \| FBXW3 \| SHFM3P1	F-box and WD repeat domain containing 4 pseudogene 1	An unspecified isoform of SKP1 interacts with FBW3.	BIND	15070733
FBXW7	AGO \| CDC4 \| DKFZp686F23254 \| FBW6 \| FBW7 \| FBX30 \| FBXO30 \| FBXW6 \| FLJ16457 \| SEL-10 \| SEL10	F-box and WD repeat domain containing 7	-	HPRD,BioGRID	11585921
FBXW8	FBW6 \| FBW8 \| FBX29 \| FBXO29 \| FBXW6 \| MGC33534	F-box and WD repeat domain containing 8	An unspecified isoform of SKP1 interacts with an unspecified isoform of FBW6.	BIND	15070733
			Affinity Capture-Western	BioGRID	12481031
			-	HPRD	10531037
GPS1	COPS1 \| CSN1 \| MGC71287	G protein pathway suppressor 1	-	HPRD	11337588
RBX1	BA554C12.1 \| MGC13357 \| MGC1481 \| RNF75 \| ROC1	ring-box 1	Affinity Capture-Western	BioGRID	12628165
SIAH1	FLJ08065 \| HUMSIAH \| Siah-1 \| Siah-1a \| hSIAH1	seven in absentia homolog 1 (Drosophila)	-	HPRD	11389839
SKP2	FBL1 \| FBXL1 \| FLB1 \| MGC1366	S-phase kinase-associated protein 2 (p45)	Skp2-Fbox interacts with SKP1A to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex.	BIND	11961546
			-	HPRD	9430629 \|9827542\|11099048
			Affinity Capture-Western Co-crystal Structure Reconstituted Complex Two-hybrid	BioGRID	9827542 \|10531035 \|10559858 \|10918611 \|11099048 \|12609982
SUGT1	SGT1	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)	Reconstituted Complex	BioGRID	12746458
TBK1	FLJ11330 \| NAK \| T2K	TANK-binding kinase 1	Affinity Capture-MS	BioGRID	14743216
TBL1X	EBI \| SMAP55 \| TBL1	transducin (beta)-like 1X-linked	-	HPRD,BioGRID	11389839
ZC3HC1	1110054L24Rik \| HSPC216 \| NIPA	zinc finger, C3HC-type containing 1	NIPA interacts with an unspecified isoform Skp1.	BIND	16009132

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_CELL_CYCLE	128	84	All SZGR genes in this pathway
KEGG_OOCYTE_MEIOSIS	114	79	All SZGR genes in this pathway
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS	138	98	All SZGR genes in this pathway
KEGG_WNT_SIGNALING_PATHWAY	151	112	All SZGR genes in this pathway
KEGG_TGF_BETA_SIGNALING_PATHWAY	86	64	All SZGR genes in this pathway
BIOCARTA_SKP2E2F_PATHWAY	10	6	All SZGR genes in this pathway
BIOCARTA_P27_PATHWAY	13	10	All SZGR genes in this pathway
PID_NOTCH_PATHWAY	59	49	All SZGR genes in this pathway
PID_BETA_CATENIN_DEG_PATHWAY	18	17	All SZGR genes in this pathway
PID_BETA_CATENIN_NUC_PATHWAY	80	60	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_WNT	65	41	All SZGR genes in this pathway
REACTOME_CELL_CYCLE	421	253	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4	90	67	All SZGR genes in this pathway
REACTOME_PROLACTIN_RECEPTOR_SIGNALING	14	11	All SZGR genes in this pathway
REACTOME_NUCLEAR_SIGNALING_BY_ERBB4	38	30	All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR	97	66	All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS	64	43	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR	126	90	All SZGR genes in this pathway
REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	46	28	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH1	70	46	All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC	325	185	All SZGR genes in this pathway
REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_	65	40	All SZGR genes in this pathway
REACTOME_G1_PHASE	38	23	All SZGR genes in this pathway
REACTOME_G1_S_TRANSITION	112	63	All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES	137	79	All SZGR genes in this pathway
REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE	85	46	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS	107	86	All SZGR genes in this pathway
REACTOME_IL1_SIGNALING	39	30	All SZGR genes in this pathway
REACTOME_CIRCADIAN_CLOCK	53	40	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH	103	64	All SZGR genes in this pathway
REACTOME_HIV_INFECTION	207	122	All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS	132	81	All SZGR genes in this pathway
REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1	51	32	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM	539	350	All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM	270	204	All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION	251	156	All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	212	129	All SZGR genes in this pathway
REACTOME_S_PHASE	109	66	All SZGR genes in this pathway
REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21	56	34	All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP	567	375	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP	305	185	All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN	537	339	All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP	530	342	All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_PRENEOPLASTIC_UP	20	10	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	1142	669	All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_UP	150	93	All SZGR genes in this pathway
LUI_THYROID_CANCER_PAX8_PPARG_DN	45	29	All SZGR genes in this pathway
LUI_TARGETS_OF_PAX8_PPARG_FUSION	34	23	All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN	712	443	All SZGR genes in this pathway
YANG_BREAST_CANCER_ESR1_BULK_UP	27	15	All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN	1024	594	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN	514	330	All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP	424	268	All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_CIS	65	38	All SZGR genes in this pathway
DER_IFN_ALPHA_RESPONSE_UP	74	48	All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_DN	121	79	All SZGR genes in this pathway
DER_IFN_BETA_RESPONSE_UP	102	67	All SZGR genes in this pathway
DER_IFN_GAMMA_RESPONSE_UP	71	45	All SZGR genes in this pathway
PARK_HSC_AND_MULTIPOTENT_PROGENITORS	50	33	All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP	151	103	All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_DN	57	39	All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_UP	71	49	All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_DN	52	33	All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_DN	88	58	All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_UP	123	75	All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN	434	302	All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_DN	54	43	All SZGR genes in this pathway
ALONSO_METASTASIS_UP	198	128	All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_DN	210	128	All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_UP	167	99	All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_BRCA1_DN	44	28	All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP	518	299	All SZGR genes in this pathway
NIELSEN_GIST	98	66	All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP	548	370	All SZGR genes in this pathway
GREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB	145	83	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP	344	215	All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN	784	464	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-130/301	50	56	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-145	420	427	1A,m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-148/152	51	57	m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-496	755	762	1A,m8	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-7	471	478	1A,m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.