Gene Page: SPRR3

Summary ?
GeneID6707
SymbolSPRR3
Synonyms-
Descriptionsmall proline rich protein 3
ReferenceMIM:182271|HGNC:HGNC:11268|Ensembl:ENSG00000163209|HPRD:01652|Vega:OTTHUMG00000013872
Gene typeprotein-coding
Map location1q21-q22
Fetal beta0.097
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_IGenome scan meta-analysisPsr: 0.0235 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00814 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg215431021152974771SPRR32.762E-4-0.2980.038DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6902183chr6121963786SPRR367070.1trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CNIH0.750.72
GLRX30.730.72
STARD3NL0.710.72
FAM103A10.700.68
MRPL150.700.65
SUCLG10.700.66
BBS40.700.74
ARMC100.700.70
MRPS350.700.74
C20orf1110.690.71
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.8-0.45-0.52
MT-ATP8-0.44-0.50
AF347015.18-0.44-0.55
AC100783.1-0.43-0.56
C10orf108-0.43-0.48
AF347015.15-0.43-0.50
AF347015.26-0.43-0.50
AF347015.27-0.42-0.49
MT-CYB-0.42-0.49
AC016705.1-0.41-0.56

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI10510474 
GO:0005198structural molecule activityTAS9889002 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008544epidermis developmentNAS8325635 
GO:0042060wound healingTAS10510474 
GO:0030216keratinocyte differentiationNAS8325635 
GO:0031424keratinizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN 17582All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS UP 14984All SZGR 2.0 genes in this pathway
LIU CDX2 TARGETS DN 85All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS DN 2513All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217143All SZGR 2.0 genes in this pathway
LIN SILENCED BY TUMOR MICROENVIRONMENT 10873All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223140All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419273All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN 154101All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE UP 10968All SZGR 2.0 genes in this pathway
BOSCO EPITHELIAL DIFFERENTIATION MODULE 6931All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway