Gene Page: UBE3A

Summary
GeneID  7337
Symbol  UBE3A
Synonyms  ANCR|AS|E6-AP|EPVE6AP|FLJ26981|HPVE6A
Description  ubiquitin protein ligase E3A
See related  HGNC:12496|MIM:601623|Ensembl:ENSG00000114062|HPRD:03375|
Locus tag  -
Gene type  protein-coding
Map location  15q11-q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ARL20.450.30
CLEC9A0.410.14
CNFN0.410.22
HLA-DPB10.410.29
HLA-DRA0.390.23
HLA-DMA0.380.22
TRAC0.380.22
HLA-DPA10.380.23
CDC42EP10.380.26
CD740.380.19
Top 10 negatively co-expressed genes
GNB4-0.17-0.09
DPP4-0.16-0.09
C14orf37-0.16-0.08
NAV3-0.16-0.06
PCDH11Y-0.16-0.15
PDE4D-0.16-0.06
MPPED1-0.16-0.07
SSBP2-0.16-0.04
RAB39-0.15-0.05
KLHL1-0.15-0.06
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI16493710 
GO:0004842ubiquitin-protein ligase activityIEA-
GO:0016874ligase activityIEA-
GO:0016881acid-amino acid ligase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentTASBrain (GO term level: 7)8988171 
GO:0006464protein modification processIEA-
GO:0006508proteolysisTAS8221889 
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0006511ubiquitin-dependent protein catabolic processTAS8221889 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolIEA-
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0043234protein complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BARD1-BRCA1 associated RING domain 1Reconstituted ComplexBioGRID12890688 
BLKMGC10442B lymphoid tyrosine kinase-HPRD,BioGRID10449731 
BPY2BPY2A | VCY2 | VCY2Abasic charge, Y-linked, 2-HPRD,BioGRID12207887 
BPY2BBPY2 | VCY2 | VCY2Bbasic charge, Y-linked, 2B-HPRD12207887 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetReconstituted ComplexBioGRID12890688 
CUL7KIAA0076 | dJ20C7.5cullin 7-HPRD12481031 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinaseReconstituted Complex
Two-hybrid		BioGRID10449731 
MCM7CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146minichromosome maintenance complex component 7-HPRD,BioGRID9852095 
PGRNR3C3 | PRprogesterone receptor-HPRD,BioGRID9891052 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD9143503 |9369221 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2Reconstituted ComplexBioGRID15175323 
UBE2D1E2(17)KB1 | SFT | UBC4/5 | UBCH5 | UBCH5Aubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)-HPRD,BioGRID10066826 
UBE2D2E2(17)KB2 | PUBC1 | UBC4 | UBC4/5 | UBCH5Bubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)Biochemical Activity
Reconstituted Complex
Two-hybrid		BioGRID9182527 |9990509 
UBE2D3E2(17)KB3 | MGC43926 | MGC5416 | UBC4/5 | UBCH5Cubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)-HPRD,BioGRID9990509 
UBE2E1UBCH6ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)-HPRD8576257 
UBE2G1E217K | UBC7 | UBE2Gubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)-HPRD10558980 
UBE2G2UBC7ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)-HPRD10558980 
UBE2L3E2-F1 | L-UBC | UBCH7 | UbcM4ubiquitin-conjugating enzyme E2L 3UbcH7 interacts with E6AP.BIND9153201 
Biochemical Activity
Co-crystal Structure		BioGRID8576257 |9990509 
|10558980 
-HPRD8576257 |10558980 
UBE2L6MGC40331 | RIG-B | UBCH8ubiquitin-conjugating enzyme E2L 6UbcH8 interacts with E6AP.BIND9153201 
-HPRD10558980 
UBQLN2CHAP1 | CHAP1/DSK2 | Dsk2 | HRIHFB2157 | LIC-2 | N4BP4 | PLIC-2 | PLIC2 | RIHFB2157ubiquilin 2-HPRD,BioGRID10983987 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 13898All SZGR genes in this pathway
BIOCARTA_PROTEASOME_PATHWAY 2819All SZGR genes in this pathway
PID_AR_PATHWAY 6146All SZGR genes in this pathway
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 212129All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_DN 196131All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_5_6WK_UP 11668All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_DN 10064All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_UP 292168All SZGR genes in this pathway
PARK_HSC_VS_MULTIPOTENT_PROGENITORS_DN 1812All SZGR genes in this pathway
MAGRANGEAS_MULTIPLE_MYELOMA_IGLL_VS_IGLK_UP 4224All SZGR genes in this pathway
GUO_HEX_TARGETS_UP 8154All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
XU_RESPONSE_TO_TRETINOIN_DN 138All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_DN 215132All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN 261183All SZGR genes in this pathway
XU_GH1_EXOGENOUS_TARGETS_DN 12069All SZGR genes in this pathway
WONG_PROTEASOME_GENE_MODULE 4935All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
MATZUK_EARLY_ANTRAL_FOLLICLE 1311All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_UP 5541All SZGR genes in this pathway
GREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB 14583All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
BRIDEAU_IMPRINTED_GENES 6347All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway


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