Gene Page: WNT3

Summary ?
GeneID7473
SymbolWNT3
SynonymsINT4|TETAMS
Descriptionwingless-type MMTV integration site family member 3
ReferenceMIM:165330|HGNC:HGNC:12782|Ensembl:ENSG00000108379|HPRD:01318|Vega:OTTHUMG00000178076
Gene typeprotein-coding
Map location17q21
Pascal p-value6.742E-4
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17029291chr332402138WNT374730.13trans
rs39336521744888715WNT3ENSG00000108379.54.339E-6021709gtex_brain_ba24
rs38517811744891301WNT3ENSG00000108379.51.044E-6019123gtex_brain_ba24
rs777683801744891767WNT3ENSG00000108379.51.429E-6018657gtex_brain_ba24
rs347241241744902516WNT3ENSG00000108379.53.931E-607908gtex_brain_ba24
rs110797381744904049WNT3ENSG00000108379.51.656E-606375gtex_brain_ba24
rs99048651744908263WNT3ENSG00000108379.52.485E-1702161gtex_brain_ba24
rs21658461744941366WNT3ENSG00000108379.52.215E-60-30942gtex_brain_ba24
rs603722681744947756WNT3ENSG00000108379.55.087E-60-37332gtex_brain_ba24
rs616199461744947757WNT3ENSG00000108379.55.095E-60-37333gtex_brain_ba24
rs579869611744947821WNT3ENSG00000108379.54.932E-60-37397gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PRR110.890.62
HJURP0.880.43
PRC10.880.63
GSG20.880.55
C15orf420.880.56
TPX20.880.56
CENPF0.880.58
HELLS0.880.51
KIF2C0.870.50
NCAPH0.870.54
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.36-0.52
PTH1R-0.35-0.43
IFI27-0.35-0.52
AF347015.27-0.35-0.49
MT-CO2-0.34-0.50
MT-CYB-0.34-0.49
AIFM3-0.34-0.41
HLA-F-0.34-0.39
FBXO2-0.34-0.37
SLC9A3R2-0.34-0.27

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG WNT SIGNALING PATHWAY 151112All SZGR 2.0 genes in this pathway
KEGG HEDGEHOG SIGNALING PATHWAY 5642All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 10280All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG BASAL CELL CARCINOMA 5544All SZGR 2.0 genes in this pathway
WNT SIGNALING 8971All SZGR 2.0 genes in this pathway
PID WNT SIGNALING PATHWAY 2823All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 8858All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
HWANG PROSTATE CANCER MARKERS 2819All SZGR 2.0 genes in this pathway
THEODOROU MAMMARY TUMORIGENESIS 3124All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
APRELIKOVA BRCA1 TARGETS 4933All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578341All SZGR 2.0 genes in this pathway
CLIMENT BREAST CANCER COPY NUMBER UP 2320All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264159All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3 269159All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway