Gene Page: TLN2
Summary ?
GeneID | 83660 |
Symbol | TLN2 |
Synonyms | ILWEQ |
Description | talin 2 |
Reference | MIM:607349|HGNC:HGNC:15447|Ensembl:ENSG00000171914|HPRD:09555|Vega:OTTHUMG00000133679 |
Gene type | protein-coding |
Map location | 15q22.2 |
Pascal p-value | 0.027 |
Sherlock p-value | 0.355 |
Support | STRUCTURAL PLASTICITY G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS CompositeSet Darnell FMRP targets |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
TEX9 | 0.80 | 0.56 |
NEK11 | 0.77 | 0.50 |
GNG12 | 0.76 | 0.46 |
TMEM67 | 0.75 | 0.53 |
TSPAN6 | 0.75 | 0.59 |
CRISPLD1 | 0.75 | 0.54 |
TTC30B | 0.75 | 0.57 |
LRRC9 | 0.74 | 0.44 |
C11orf70 | 0.74 | 0.39 |
NUP62CL | 0.73 | 0.49 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
ASPHD1 | -0.30 | -0.35 |
HLA-F | -0.29 | -0.33 |
ARRDC2 | -0.28 | -0.37 |
MT-CO2 | -0.28 | -0.36 |
TINAGL1 | -0.28 | -0.35 |
AF347015.33 | -0.27 | -0.35 |
GRASP | -0.27 | -0.34 |
AF347015.27 | -0.27 | -0.34 |
CA4 | -0.27 | -0.31 |
CA11 | -0.27 | -0.34 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG FOCAL ADHESION | 201 | 138 | All SZGR 2.0 genes in this pathway |
ST INTEGRIN SIGNALING PATHWAY | 82 | 62 | All SZGR 2.0 genes in this pathway |
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN | 169 | 118 | All SZGR 2.0 genes in this pathway |
KIM WT1 TARGETS 12HR UP | 162 | 116 | All SZGR 2.0 genes in this pathway |
BACOLOD RESISTANCE TO ALKYLATING AGENTS DN | 60 | 45 | All SZGR 2.0 genes in this pathway |
HELLER HDAC TARGETS SILENCED BY METHYLATION UP | 461 | 298 | All SZGR 2.0 genes in this pathway |
MASSARWEH TAMOXIFEN RESISTANCE UP | 578 | 341 | All SZGR 2.0 genes in this pathway |
GRADE COLON AND RECTAL CANCER DN | 101 | 65 | All SZGR 2.0 genes in this pathway |
BOYLAN MULTIPLE MYELOMA D UP | 89 | 62 | All SZGR 2.0 genes in this pathway |
YAGI AML WITH INV 16 TRANSLOCATION | 422 | 277 | All SZGR 2.0 genes in this pathway |
BOYLAN MULTIPLE MYELOMA PCA3 UP | 80 | 54 | All SZGR 2.0 genes in this pathway |
BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
PURBEY TARGETS OF CTBP1 AND SATB1 DN | 180 | 116 | All SZGR 2.0 genes in this pathway |
YANG BCL3 TARGETS UP | 364 | 236 | All SZGR 2.0 genes in this pathway |
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN | 308 | 187 | All SZGR 2.0 genes in this pathway |