Gene Page: ATG10
Summary ?
| GeneID | 83734 |
| Symbol | ATG10 |
| Synonyms | APG10|APG10L|pp12616 |
| Description | autophagy related 10 |
| Reference | MIM:610800|HGNC:HGNC:20315|HPRD:16497| |
| Gene type | protein-coding |
| Map location | 5q14.1 |
| Pascal p-value | 0.009 |
| Sherlock p-value | 0.291 |
| eGene | Anterior cingulate cortex BA24 Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Nucleus accumbens basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs74906189 | 5 | 81261923 | ATG10 | ENSG00000152348.11 | 1.07E-6 | 0.02 | -5921 | gtex_brain_ba24 |
| rs4391141 | 5 | 81263522 | ATG10 | ENSG00000152348.11 | 1.212E-6 | 0.02 | -4322 | gtex_brain_ba24 |
| rs111549985 | 5 | 81268070 | ATG10 | ENSG00000152348.11 | 1.387E-6 | 0.02 | 226 | gtex_brain_ba24 |
| rs73134709 | 5 | 81268499 | ATG10 | ENSG00000152348.11 | 1.401E-6 | 0.02 | 655 | gtex_brain_ba24 |
| rs34981833 | 5 | 81272732 | ATG10 | ENSG00000152348.11 | 1.568E-6 | 0.02 | 4888 | gtex_brain_ba24 |
| rs2406909 | 5 | 81276087 | ATG10 | ENSG00000152348.11 | 8.336E-7 | 0.02 | 8243 | gtex_brain_ba24 |
| rs2897554 | 5 | 81276241 | ATG10 | ENSG00000152348.11 | 8.353E-7 | 0.02 | 8397 | gtex_brain_ba24 |
| rs12108681 | 5 | 81278375 | ATG10 | ENSG00000152348.11 | 1.42E-6 | 0.02 | 10531 | gtex_brain_ba24 |
| rs145230108 | 5 | 81281364 | ATG10 | ENSG00000152348.11 | 1.914E-6 | 0.02 | 13520 | gtex_brain_ba24 |
| rs113046446 | 5 | 81296479 | ATG10 | ENSG00000152348.11 | 1.632E-6 | 0.02 | 28635 | gtex_brain_ba24 |
| rs6875409 | 5 | 81297077 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 29233 | gtex_brain_ba24 |
| rs61024879 | 5 | 81301825 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 33981 | gtex_brain_ba24 |
| rs2406910 | 5 | 81308719 | ATG10 | ENSG00000152348.11 | 8.353E-7 | 0.02 | 40875 | gtex_brain_ba24 |
| rs111733984 | 5 | 81310879 | ATG10 | ENSG00000152348.11 | 2.846E-6 | 0.02 | 43035 | gtex_brain_ba24 |
| rs2406911 | 5 | 81312256 | ATG10 | ENSG00000152348.11 | 2.243E-6 | 0.02 | 44412 | gtex_brain_ba24 |
| rs111907176 | 5 | 81312399 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 44555 | gtex_brain_ba24 |
| rs17243791 | 5 | 81322547 | ATG10 | ENSG00000152348.11 | 1.232E-6 | 0.02 | 54703 | gtex_brain_ba24 |
| rs73134722 | 5 | 81326622 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 58778 | gtex_brain_ba24 |
| rs7733122 | 5 | 81351443 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 83599 | gtex_brain_ba24 |
| rs112413913 | 5 | 81359709 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 91865 | gtex_brain_ba24 |
| rs5869104 | 5 | 81359771 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 91927 | gtex_brain_ba24 |
| rs73134739 | 5 | 81370760 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 102916 | gtex_brain_ba24 |
| rs12108833 | 5 | 81371755 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 103911 | gtex_brain_ba24 |
| rs144580806 | 5 | 81375335 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 107491 | gtex_brain_ba24 |
| rs111842222 | 5 | 81377257 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 109413 | gtex_brain_ba24 |
| rs73134747 | 5 | 81378294 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 110450 | gtex_brain_ba24 |
| rs2629744 | 5 | 81381997 | ATG10 | ENSG00000152348.11 | 1.507E-6 | 0.02 | 114153 | gtex_brain_ba24 |
| rs112355050 | 5 | 81386035 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 118191 | gtex_brain_ba24 |
| rs324914 | 5 | 81389950 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 122106 | gtex_brain_ba24 |
| rs324910 | 5 | 81400264 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 132420 | gtex_brain_ba24 |
| rs57621982 | 5 | 81406770 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 138926 | gtex_brain_ba24 |
| rs199607724 | 5 | 81422172 | ATG10 | ENSG00000152348.11 | 8.566E-7 | 0.02 | 154328 | gtex_brain_ba24 |
| rs139245895 | 5 | 81422885 | ATG10 | ENSG00000152348.11 | 1.227E-6 | 0.02 | 155041 | gtex_brain_ba24 |
| rs4293895 | 5 | 81425592 | ATG10 | ENSG00000152348.11 | 1.554E-6 | 0.02 | 157748 | gtex_brain_ba24 |
| rs73136777 | 5 | 81434479 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 166635 | gtex_brain_ba24 |
| rs73136782 | 5 | 81443520 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 175676 | gtex_brain_ba24 |
| rs1428940 | 5 | 81447995 | ATG10 | ENSG00000152348.11 | 1.648E-6 | 0.02 | 180151 | gtex_brain_ba24 |
| rs60733727 | 5 | 81448283 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 180439 | gtex_brain_ba24 |
| rs2407064 | 5 | 81457358 | ATG10 | ENSG00000152348.11 | 3.777E-7 | 0.02 | 189514 | gtex_brain_ba24 |
| rs10068160 | 5 | 81466075 | ATG10 | ENSG00000152348.11 | 1.319E-6 | 0.02 | 198231 | gtex_brain_ba24 |
| rs4081859 | 5 | 81466669 | ATG10 | ENSG00000152348.11 | 1.319E-6 | 0.02 | 198825 | gtex_brain_ba24 |
| rs17245188 | 5 | 81469082 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 201238 | gtex_brain_ba24 |
| rs6452447 | 5 | 81482522 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 214678 | gtex_brain_ba24 |
| rs891159 | 5 | 81491087 | ATG10 | ENSG00000152348.11 | 1.321E-6 | 0.02 | 223243 | gtex_brain_ba24 |
| rs4703870 | 5 | 81492643 | ATG10 | ENSG00000152348.11 | 1.321E-6 | 0.02 | 224799 | gtex_brain_ba24 |
| rs79616997 | 5 | 81504600 | ATG10 | ENSG00000152348.11 | 1.319E-6 | 0.02 | 236756 | gtex_brain_ba24 |
| rs1543911 | 5 | 81504841 | ATG10 | ENSG00000152348.11 | 1.636E-6 | 0.02 | 236997 | gtex_brain_ba24 |
| rs2059891 | 5 | 81508792 | ATG10 | ENSG00000152348.11 | 1.326E-6 | 0.02 | 240948 | gtex_brain_ba24 |
| rs146817970 | 5 | 81512947 | ATG10 | ENSG00000152348.11 | 1.326E-6 | 0.02 | 245103 | gtex_brain_ba24 |
| rs6888977 | 5 | 81533735 | ATG10 | ENSG00000152348.11 | 1.319E-6 | 0.02 | 265891 | gtex_brain_ba24 |
| rs7707921 | 5 | 81538046 | ATG10 | ENSG00000152348.11 | 1.319E-6 | 0.02 | 270202 | gtex_brain_ba24 |
| rs6884232 | 5 | 81550043 | ATG10 | ENSG00000152348.11 | 1.319E-6 | 0.02 | 282199 | gtex_brain_ba24 |
| rs1019806 | 5 | 81551659 | ATG10 | ENSG00000152348.11 | 1.319E-6 | 0.02 | 283815 | gtex_brain_ba24 |
| rs4703879 | 5 | 81553815 | ATG10 | ENSG00000152348.11 | 1.319E-6 | 0.02 | 285971 | gtex_brain_ba24 |
| rs2407153 | 5 | 81555328 | ATG10 | ENSG00000152348.11 | 1.319E-6 | 0.02 | 287484 | gtex_brain_ba24 |
| rs749402 | 5 | 81561325 | ATG10 | ENSG00000152348.11 | 1.225E-6 | 0.02 | 293481 | gtex_brain_ba24 |
| rs749401 | 5 | 81561369 | ATG10 | ENSG00000152348.11 | 1.225E-6 | 0.02 | 293525 | gtex_brain_ba24 |
| rs73138787 | 5 | 81568934 | ATG10 | ENSG00000152348.11 | 7.302E-7 | 0.02 | 301090 | gtex_brain_ba24 |
| rs3738 | 5 | 81569293 | ATG10 | ENSG00000152348.11 | 6.294E-7 | 0.02 | 301449 | gtex_brain_ba24 |
| rs3739 | 5 | 81569311 | ATG10 | ENSG00000152348.11 | 6.303E-7 | 0.02 | 301467 | gtex_brain_ba24 |
| rs226203 | 5 | 81570394 | ATG10 | ENSG00000152348.11 | 3.639E-7 | 0.02 | 302550 | gtex_brain_ba24 |
| rs11346477 | 5 | 81571266 | ATG10 | ENSG00000152348.11 | 6.426E-7 | 0.02 | 303422 | gtex_brain_ba24 |
| rs226202 | 5 | 81571669 | ATG10 | ENSG00000152348.11 | 6.426E-7 | 0.02 | 303825 | gtex_brain_ba24 |
| rs226199 | 5 | 81572464 | ATG10 | ENSG00000152348.11 | 6.426E-7 | 0.02 | 304620 | gtex_brain_ba24 |
| rs226198 | 5 | 81573992 | ATG10 | ENSG00000152348.11 | 1.319E-6 | 0.02 | 306148 | gtex_brain_ba24 |
| rs6880209 | 5 | 81574182 | ATG10 | ENSG00000152348.11 | 6.426E-7 | 0.02 | 306338 | gtex_brain_ba24 |
| rs226197 | 5 | 81574925 | ATG10 | ENSG00000152348.11 | 6.426E-7 | 0.02 | 307081 | gtex_brain_ba24 |
| rs178931 | 5 | 81575601 | ATG10 | ENSG00000152348.11 | 6.426E-7 | 0.02 | 307757 | gtex_brain_ba24 |
| rs226196 | 5 | 81576965 | ATG10 | ENSG00000152348.11 | 6.426E-7 | 0.02 | 309121 | gtex_brain_ba24 |
| rs10607783 | 5 | 81579072 | ATG10 | ENSG00000152348.11 | 6.107E-7 | 0.02 | 311228 | gtex_brain_ba24 |
| rs226194 | 5 | 81585026 | ATG10 | ENSG00000152348.11 | 6.426E-7 | 0.02 | 317182 | gtex_brain_ba24 |
| rs862245 | 5 | 81585737 | ATG10 | ENSG00000152348.11 | 6.426E-7 | 0.02 | 317893 | gtex_brain_ba24 |
| rs862244 | 5 | 81586801 | ATG10 | ENSG00000152348.11 | 6.426E-7 | 0.02 | 318957 | gtex_brain_ba24 |
| rs862243 | 5 | 81586829 | ATG10 | ENSG00000152348.11 | 6.426E-7 | 0.02 | 318985 | gtex_brain_ba24 |
| rs862242 | 5 | 81587566 | ATG10 | ENSG00000152348.11 | 6.426E-7 | 0.02 | 319722 | gtex_brain_ba24 |
| rs862241 | 5 | 81588011 | ATG10 | ENSG00000152348.11 | 6.426E-7 | 0.02 | 320167 | gtex_brain_ba24 |
| rs6870335 | 5 | 81590070 | ATG10 | ENSG00000152348.11 | 6.342E-7 | 0.02 | 322226 | gtex_brain_ba24 |
| rs226206 | 5 | 81593019 | ATG10 | ENSG00000152348.11 | 6.228E-7 | 0.02 | 325175 | gtex_brain_ba24 |
| rs226205 | 5 | 81593654 | ATG10 | ENSG00000152348.11 | 1.313E-6 | 0.02 | 325810 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| WANG LMO4 TARGETS UP | 372 | 227 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP | 211 | 136 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS EARLY PROGENITOR | 532 | 309 | All SZGR 2.0 genes in this pathway |
| CUI TCF21 TARGETS 2 DN | 830 | 547 | All SZGR 2.0 genes in this pathway |
| FOSTER KDM1A TARGETS UP | 266 | 142 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |
| MIZUSHIMA AUTOPHAGOSOME FORMATION | 19 | 15 | All SZGR 2.0 genes in this pathway |