Gene Page: PCGF6
Summary ?
| GeneID | 84108 |
| Symbol | PCGF6 |
| Synonyms | MBLR|RNF134 |
| Description | polycomb group ring finger 6 |
| Reference | MIM:607816|HGNC:HGNC:21156|Ensembl:ENSG00000156374|HPRD:07427|Vega:OTTHUMG00000018982 |
| Gene type | protein-coding |
| Map location | 10q24.33 |
| Pascal p-value | 6.469E-4 |
| Sherlock p-value | 0.418 |
| Fetal beta | 0.65 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| LK:YES | Genome-wide Association Study | This data set included 99 genes mapped to the 22 regions. The 24 leading SNPs were also included in CV:Ripke_2013 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6536929 | 0 | PCGF6 | 84108 | 0.11 | trans | |||
| rs3752278 | chr20 | 37050816 | PCGF6 | 84108 | 0.17 | trans | ||
| rs788350 | chr20 | 37064635 | PCGF6 | 84108 | 0.18 | trans | ||
| rs1303567 | chr20 | 37106156 | PCGF6 | 84108 | 0.05 | trans | ||
| rs805554 | chr20 | 37107040 | PCGF6 | 84108 | 0.09 | trans | ||
| rs1303577 | chr20 | 37125856 | PCGF6 | 84108 | 0.17 | trans | ||
| rs1303575 | chr20 | 37128816 | PCGF6 | 84108 | 0.17 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| LIU SOX4 TARGETS DN | 309 | 191 | All SZGR 2.0 genes in this pathway |
| WANG LMO4 TARGETS DN | 352 | 225 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN | 180 | 101 | All SZGR 2.0 genes in this pathway |
| COLDREN GEFITINIB RESISTANCE UP | 85 | 57 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| SHETH LIVER CANCER VS TXNIP LOSS PAM1 | 229 | 137 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE EARLY LATE | 317 | 190 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |