SZGR2

Summary ?

GeneID	842
Symbol	CASP9
Synonyms	APAF-3\|APAF3\|ICE-LAP6\|MCH6\|PPP1R56
Description	caspase 9
Reference	MIM:602234\|HGNC:HGNC:1511\|Ensembl:ENSG00000132906\|HPRD:03756\|Vega:OTTHUMG00000002256
Gene type	protein-coding
Map location	1p36.21
Pascal p-value	0.677
Sherlock p-value	0.329
Fetal beta	-1.335
DMG	1 (# studies)
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg20153829	1	15848307	CASP9	3.371E-4	0.304	0.041	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs12718316	chr7	49035889	CASP9	842		0.05		trans
rs4132419	chr7	49066632	CASP9	842		0.16		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
CARD11	0.75	0.58
CHRNA2	0.73	0.55
ATP2A3	0.71	0.08
AL133445.2	0.71	0.31
SUSD2	0.71	0.38
EPN3	0.68	0.43
FAM19A4	0.68	0.56
FAM20A	0.68	0.27
CHRNA3	0.68	0.44
PLCB4	0.68	0.34

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
PLEKHO1	-0.18	-0.24
EMID1	-0.17	-0.32
IER5L	-0.16	-0.09
WDR86	-0.16	-0.20
NR2C2AP	-0.15	-0.22
TMEM44	-0.15	-0.18
RPL35	-0.15	-0.30
TMEM159	-0.15	-0.15
RPL18	-0.15	-0.38
CHRDL1	-0.15	-0.09

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	-	HPRD	15657060
APAF1	CED4 \| DKFZp781B1145	apoptotic peptidase activating factor 1	-	HPRD,BioGRID	9390557 \|9488720
APAF1	CED4 \| DKFZp781B1145	apoptotic peptidase activating factor 1	APAF1 interacts with CASP9.	BIND	15829969
APAF1	CED4 \| DKFZp781B1145	apoptotic peptidase activating factor 1	-	HPRD	9390557 \|9488720 \|9539746 \|9837928 \|10376594
BCL10	CARMEN \| CIPER \| CLAP \| c-E10 \| mE10	B-cell CLL/lymphoma 10	-	HPRD	10187815
BCL2L1	BCL-XL/S \| BCL2L \| BCLX \| Bcl-X \| DKFZp781P2092 \| bcl-xL \| bcl-xS	BCL2-like 1	-	HPRD,BioGRID	9539746
BIRC2	API1 \| HIAP2 \| Hiap-2 \| MIHB \| RNF48 \| cIAP1	baculoviral IAP repeat-containing 2	-	HPRD,BioGRID	9545235
BIRC3	AIP1 \| API2 \| CIAP2 \| HAIP1 \| HIAP1 \| MALT2 \| MIHC \| RNF49	baculoviral IAP repeat-containing 3	-	HPRD,BioGRID	9545235
BIRC5	API4 \| EPR-1	baculoviral IAP repeat-containing 5	-	HPRD,BioGRID	11069302
BIRC6	APOLLON \| BRUCE \| FLJ13726 \| FLJ13786 \| KIAA1289	baculoviral IAP repeat-containing 6	-	HPRD	15300255
BIRC6	APOLLON \| BRUCE \| FLJ13726 \| FLJ13786 \| KIAA1289	baculoviral IAP repeat-containing 6	BRUCE interacts with Casp-9. This interaction was modeled on a demonstrated interaction between mouse BRUCE and human Casp-9.	BIND	15200957
BIRC6	APOLLON \| BRUCE \| FLJ13726 \| FLJ13786 \| KIAA1289	baculoviral IAP repeat-containing 6	Apollon interacts with and ubiquitinates Caspase-9.	BIND	15300255
BIRC7	KIAP \| LIVIN \| ML-IAP \| MLIAP \| RNF50	baculoviral IAP repeat-containing 7	-	HPRD,BioGRID	11024045
BIRC8	ILP-2 \| ILP2 \| hILP2	baculoviral IAP repeat-containing 8	-	HPRD,BioGRID	11390657
CARD8	CARDINAL \| DACAR \| DKFZp779L0366 \| Dakar \| FLJ18119 \| FLJ18121 \| KIAA0955 \| MGC57162 \| NDPP \| NDPP1 \| TUCAN	caspase recruitment domain family, member 8	-	HPRD	11408476
CASP10	ALPS2 \| FLICE2 \| MCH4	caspase 10, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	8962078
CASP2	CASP-2 \| ICH-1L \| ICH-1L/1S \| ICH1 \| NEDD2	caspase 2, apoptosis-related cysteine peptidase	Phenotypic Suppression	BioGRID	11832478
CASP3	CPP32 \| CPP32B \| SCA-1	caspase 3, apoptosis-related cysteine peptidase	-	HPRD	11230124
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	Biochemical Activity Phenotypic Suppression	BioGRID	8962078 \|11832478
CASP9	APAF-3 \| APAF3 \| CASPASE-9c \| ICE-LAP6 \| MCH6	caspase 9, apoptosis-related cysteine peptidase	-	HPRD	9651578
CYCS	CYC \| HCS	cytochrome c, somatic	-	HPRD	12147322
DCC	CRC18 \| CRCR1	deleted in colorectal carcinoma	-	HPRD,BioGRID	11248093
DSP	DPI \| DPII	desmoplakin	-	HPRD	15500642
GZMB	CCPI \| CGL-1 \| CGL1 \| CSP-B \| CSPB \| CTLA1 \| CTSGL1 \| HLP \| SECT	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	-	HPRD	8900201
HSPD1	CPN60 \| GROEL \| HSP60 \| HSP65 \| HuCHA60 \| SPG13	heat shock 60kDa protein 1 (chaperonin)	-	HPRD	11230124
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	mitogen-activated protein kinase 1	-	HPRD,BioGRID	12792650
MAPK3	ERK1 \| HS44KDAP \| HUMKER1A \| MGC20180 \| P44ERK1 \| P44MAPK \| PRKM3	mitogen-activated protein kinase 3	-	HPRD	12792650
MGC29506	FLJ32987 \| PACAP	hypothetical protein MGC29506	-	HPRD	11350957
NAIP	BIRC1 \| FLJ18088 \| FLJ42520 \| FLJ58811 \| NLRB1 \| psiNAIP	NLR family, apoptosis inhibitory protein	-	HPRD,BioGRID	15280366
NLRP1	CARD7 \| CLR17.1 \| DEFCAP \| DEFCAP-L/S \| DKFZp586O1822 \| KIAA0926 \| NAC \| NALP1 \| PP1044 \| SLEV1 \| VAMAS1	NLR family, pyrin domain containing 1	-	HPRD,BioGRID	11076957
NOD1	CARD4 \| CLR7.1 \| NLRC1	nucleotide-binding oligomerization domain containing 1	Nod1 interacts with and regulates Caspase-9	BIND	10329646
NOD1	CARD4 \| CLR7.1 \| NLRC1	nucleotide-binding oligomerization domain containing 1	-	HPRD,BioGRID	10329646
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	CASP9 (caspase-9) cleaves RB-1 (hRB) at the LEND consensus site to produce the p76 form.	BIND	15735701
XIAP	API3 \| BIRC4 \| ILP1 \| MIHA \| XLP2	X-linked inhibitor of apoptosis	XIAP interacts with and ubiquitinates Caspase-9.	BIND	15300255
XIAP	API3 \| BIRC4 \| ILP1 \| MIHA \| XLP2	X-linked inhibitor of apoptosis	Affinity Capture-Western Far Western Reconstituted Complex Two-hybrid	BioGRID	9545235 \|11390657 \|15280366 \|16189514
XIAP	API3 \| BIRC4 \| ILP1 \| MIHA \| XLP2	X-linked inhibitor of apoptosis	-	HPRD	9545235 \|11927604

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG P53 SIGNALING PATHWAY	69	45	All SZGR 2.0 genes in this pathway
KEGG APOPTOSIS	88	62	All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY	76	53	All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE	169	110	All SZGR 2.0 genes in this pathway
KEGG PARKINSONS DISEASE	133	78	All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS	53	43	All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE	185	109	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER	62	47	All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER	70	56	All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER	52	45	All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER	89	75	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER	54	47	All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS	73	58	All SZGR 2.0 genes in this pathway
BIOCARTA AKT PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA CHEMICAL PATHWAY	22	15	All SZGR 2.0 genes in this pathway
BIOCARTA CASPASE PATHWAY	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA D4GDI PATHWAY	13	8	All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA DEATH PATHWAY	33	24	All SZGR 2.0 genes in this pathway
BIOCARTA RAS PATHWAY	23	20	All SZGR 2.0 genes in this pathway
BIOCARTA MITOCHONDRIA PATHWAY	21	15	All SZGR 2.0 genes in this pathway
BIOCARTA HSP27 PATHWAY	15	11	All SZGR 2.0 genes in this pathway
BIOCARTA TFF PATHWAY	21	15	All SZGR 2.0 genes in this pathway
SA CASPASE CASCADE	19	13	All SZGR 2.0 genes in this pathway
SA PROGRAMMED CELL DEATH	12	9	All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY	69	51	All SZGR 2.0 genes in this pathway
PID HIV NEF PATHWAY	35	26	All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY	52	39	All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY	35	30	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4	90	67	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME PI3K EVENTS IN ERBB4 SIGNALING	38	28	All SZGR 2.0 genes in this pathway
REACTOME PI3K EVENTS IN ERBB2 SIGNALING	44	34	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	97	66	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	126	90	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME PI3K AKT ACTIVATION	38	29	All SZGR 2.0 genes in this pathway
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	12	10	All SZGR 2.0 genes in this pathway
REACTOME GAB1 SIGNALOSOME	38	29	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF APOPTOSIS	58	34	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME PI 3K CASCADE	56	39	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	10	5	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS	148	94	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME NOD1 2 SIGNALING PATHWAY	30	22	All SZGR 2.0 genes in this pathway
REACTOME PIP3 ACTIVATES AKT SIGNALING	29	20	All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	46	33	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	30	21	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 DN	52	34	All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN	391	222	All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS DN	186	114	All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP	176	123	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN	394	258	All SZGR 2.0 genes in this pathway
MARKS HDAC TARGETS UP	23	15	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
TSUNODA CISPLATIN RESISTANCE DN	51	38	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP	292	168	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE DN	77	49	All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS	66	48	All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC	182	116	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA DN	39	29	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND UP	77	52	All SZGR 2.0 genes in this pathway
XU CREBBP TARGETS DN	44	31	All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS DN	16	11	All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP	71	49	All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA UP	52	33	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
GAJATE RESPONSE TO TRABECTEDIN UP	67	45	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP	388	234	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP	439	257	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN	546	362	All SZGR 2.0 genes in this pathway
CLIMENT BREAST CANCER COPY NUMBER DN	8	7	All SZGR 2.0 genes in this pathway
BREDEMEYER RAG SIGNALING VIA ATM NOT VIA NFKB DN	38	23	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
NICK RESPONSE TO PROC TREATMENT DN	27	18	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS	535	325	All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP	83	63	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP	91	59	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP	90	58	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF	222	159	All SZGR 2.0 genes in this pathway

Gene Page: CASP9