SZGR2

Summary ?

GeneID	8428
Symbol	STK24
Synonyms	HEL-S-95\|MST3\|MST3B\|STE20\|STK3
Description	serine/threonine kinase 24
Reference	MIM:604984\|HGNC:HGNC:11403\|Ensembl:ENSG00000102572\|HPRD:10385\|
Gene type	protein-coding
Map location	13q31.2-q32.3
Pascal p-value	0.454
Sherlock p-value	0.721
DMG	1 (# studies)
eGene	Cerebellar Hemisphere Cerebellum

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	2

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg04407579	13	99228509	STK24	1.18E-4	-0.199	0.029	DMG:Wockner_2014
cg19300307	13	99136580	STK24	1.277E-4	0.741	0.03	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0005524	ATP binding	IEA		-
GO:0004674	protein serine/threonine kinase activity	IEA		-
GO:0004713	protein tyrosine kinase activity	IEA		-
GO:0016740	transferase activity	IEA		-
GO:0016301	kinase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0007165	signal transduction	TAS		9353338
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APOD	-	apolipoprotein D	Affinity Capture-MS	BioGRID	17353931
CCT2	99D8.1 \| CCT-beta \| CCTB \| MGC142074 \| MGC142076 \| PRO1633 \| TCP-1-beta	chaperonin containing TCP1, subunit 2 (beta)	Affinity Capture-MS	BioGRID	18782753
CCT3	CCT-gamma \| CCTG \| PIG48 \| TCP-1-gamma \| TRIC5	chaperonin containing TCP1, subunit 3 (gamma)	Affinity Capture-MS	BioGRID	18782753
CCT4	CCT-DELTA \| Cctd \| MGC126164 \| MGC126165 \| SRB	chaperonin containing TCP1, subunit 4 (delta)	Affinity Capture-MS	BioGRID	18782753
CCT5	CCT-epsilon \| CCTE \| KIAA0098 \| TCP-1-epsilon	chaperonin containing TCP1, subunit 5 (epsilon)	Affinity Capture-MS	BioGRID	18782753
CCT6A	CCT-zeta \| CCT-zeta-1 \| CCT6 \| Cctz \| HTR3 \| MGC126214 \| MGC126215 \| MoDP-2 \| TCP-1-zeta \| TCP20 \| TCPZ \| TTCP20	chaperonin containing TCP1, subunit 6A (zeta 1)	Affinity Capture-MS	BioGRID	18782753
CCT7	CCT-ETA \| Ccth \| MGC110985 \| Nip7-1 \| TCP-1-eta	chaperonin containing TCP1, subunit 7 (eta)	Affinity Capture-MS	BioGRID	18782753
CCT8	C21orf112 \| Cctq \| D21S246 \| KIAA0002 \| PRED71	chaperonin containing TCP1, subunit 8 (theta)	Affinity Capture-MS	BioGRID	18782753
CTTNBP2	C7orf8 \| CORTBP2 \| FLJ34229 \| KIAA1758 \| MGC104579 \| Orf4	cortactin binding protein 2	Affinity Capture-MS	BioGRID	18782753
CTTNBP2NL	DKFZp547A023 \| FLJ13278	CTTNBP2 N-terminal like	Affinity Capture-MS Affinity Capture-Western	BioGRID	18782753
DDX5	DKFZp686J01190 \| G17P1 \| HLR1 \| HUMP68 \| p68	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	Affinity Capture-MS	BioGRID	17353931
DSP	DPI \| DPII	desmoplakin	Affinity Capture-MS	BioGRID	17353931
FABP5	E-FABP \| EFABP \| PA-FABP \| PAFABP	fatty acid binding protein 5 (psoriasis-associated)	Affinity Capture-MS	BioGRID	17353931
FAM40A	FLJ14743 \| KIAA1761 \| MGC148091 \| RP4-773N10.1	family with sequence similarity 40, member A	Affinity Capture-MS	BioGRID	17353931 \|18782753
FAM40B	-	family with sequence similarity 40, member B	Affinity Capture-MS	BioGRID	18782753
FGFR1OP2	DKFZp564O1863 \| HSPC123-like	FGFR1 oncogene partner 2	Affinity Capture-MS	BioGRID	18782753
G3BP2	-	GTPase activating protein (SH3 domain) binding protein 2	Affinity Capture-MS	BioGRID	17353931
HNRNPA3	2610510D13Rik \| D10S102 \| FBRNP \| HNRPA3 \| MGC138232 \| MGC142030	heterogeneous nuclear ribonucleoprotein A3	Affinity Capture-MS	BioGRID	17353931
HNRNPH3	2H9 \| FLJ34092 \| HNRPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	Affinity Capture-MS	BioGRID	17353931
JPH3	CAGL237 \| FLJ44707 \| HDL2 \| JP-3 \| JP3 \| TNRC22	junctophilin 3	Affinity Capture-MS	BioGRID	17353931
MCC	DKFZp762O1615 \| FLJ38893 \| FLJ46755 \| MCC1	mutated in colorectal cancers	Affinity Capture-MS	BioGRID	17353931
MOBKL3	2C4D \| CGI-95 \| MGC12264 \| MOB1 \| MOB3 \| PREI3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	Affinity Capture-MS	BioGRID	17353931 \|18782753
PDCD10	CCM3 \| MGC1212 \| MGC24477 \| TFAR15	programmed cell death 10	Affinity Capture-MS Two-hybrid	BioGRID	16189514 \|17353931 \|18782753
PDCD6IP	AIP1 \| Alix \| DRIP4 \| HP95 \| MGC17003	programmed cell death 6 interacting protein	Affinity Capture-MS	BioGRID	17353931
PPP2CA	PP2Ac \| PP2CA \| RP-C	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Affinity Capture-MS	BioGRID	18782753
PPP2CB	PP2CB	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	Affinity Capture-MS	BioGRID	17353931
PPP2R1A	MGC786 \| PR65A	protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform	Affinity Capture-MS	BioGRID	17353931 \|18782753
PPP2R1B	MGC26454 \| PR65B	protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform	Affinity Capture-MS	BioGRID	18782753
RP5-1000E10.4	DKFZp686A0768 \| FLJ21168 \| SIKE	suppressor of IKK epsilon	Affinity Capture-MS	BioGRID	18782753
SLMAP	FLJ42206 \| KIAA1601 \| MGC138760 \| MGC138761 \| SLAP	sarcolemma associated protein	Affinity Capture-MS	BioGRID	17353931 \|18782753
STK25	DKFZp686J1430 \| SOK1 \| YSK1	serine/threonine kinase 25 (STE20 homolog, yeast)	Affinity Capture-MS	BioGRID	17353931
STRN	MGC125642 \| SG2NA	striatin, calmodulin binding protein	Affinity Capture-MS Affinity Capture-Western	BioGRID	17353931 \|18782753
STRN3	SG2NA	striatin, calmodulin binding protein 3	Affinity Capture-MS	BioGRID	17353931 \|18782753
STRN4	FLJ35594 \| ZIN \| zinedin	striatin, calmodulin binding protein 4	Affinity Capture-MS	BioGRID	17353931 \|18782753
SYNCRIP	GRY-RBP \| HNRPQ1 \| NSAP1 \| RP1-3J17.2 \| dJ3J17.2 \| hnRNP-Q \| pp68	synaptotagmin binding, cytoplasmic RNA interacting protein	Affinity Capture-MS	BioGRID	17353931
TCP1	CCT-alpha \| CCT1 \| CCTa \| D6S230E \| TCP-1-alpha	t-complex 1	Affinity Capture-MS	BioGRID	18782753
TRAF3IP3	DJ434O14.3 \| FLJ44151 \| MGC117354 \| MGC163289 \| T3JAM	TRAF3 interacting protein 3	Affinity Capture-MS Affinity Capture-Western	BioGRID	18782753
ZBTB24	BIF1 \| PATZ2 \| ZNF450	zinc finger and BTB domain containing 24	Affinity Capture-MS	BioGRID	17353931

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	40	26	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS	148	94	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE	54	37	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP	176	123	All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP	214	134	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS DN	25	13	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
UEDA CENTRAL CLOCK	88	62	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN	121	79	All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO MERCAPTOPURINE AND LD MTX UP	10	6	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
JIANG VHL TARGETS	138	91	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D8	40	29	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3	720	440	All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3	491	310	All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP	198	128	All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION	175	125	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA MS DN	46	24	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS DN	87	66	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN DN	88	68	All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION	456	287	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP	281	183	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-122	670	676	m8	hsa-miR-122a	UGGAGUGUGACAAUGGUGUUUGU
miR-128	482	488	m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	482	488	m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-139	509	515	1A	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-190	793	799	m8	hsa-miR-190	UGAUAUGUUUGAUAUAUUAGGU
miR-320	811	817	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-381	432	438	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-455	268	274	1A	hsa-miR-455	UAUGUGCCUUUGGACUACAUCG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: STK24