SZGR2

Summary ?

GeneID	84687
Symbol	PPP1R9B
Synonyms	PPP1R6\|PPP1R9\|SPINO\|Spn
Description	protein phosphatase 1 regulatory subunit 9B
Reference	MIM:603325\|HGNC:HGNC:9298\|Ensembl:ENSG00000108819\|HPRD:04506\|Vega:OTTHUMG00000162008
Gene type	protein-coding
Map location	17q21.33
Pascal p-value	0.287
Fetal beta	0.115
Support	INTRACELLULAR SIGNAL TRANSDUCTION G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanPSD G2Cdb.humanPSP Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 2
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.9202

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003779	actin binding	IEA		-
GO:0005515	protein binding	IPI		11278317
GO:0004864	protein phosphatase inhibitor activity	NAS		11278317
GO:0008157	protein phosphatase 1 binding	NAS		11278317
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007399	nervous system development	IEA	neurite (GO term level: 5)	-
GO:0001560	regulation of cell growth by extracellular stimulus	TAS		11278317
GO:0008380	RNA splicing	NAS		11278317
GO:0007050	cell cycle arrest	TAS		11278317
GO:0007096	regulation of exit from mitosis	NAS		11278317
GO:0007275	multicellular organismal development	IEA		-
GO:0030154	cell differentiation	IEA		-
GO:0042127	regulation of cell proliferation	NAS		11278317
GO:0030308	negative regulation of cell growth	IDA		11278317
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0042995	cell projection	IEA	axon (GO term level: 4)	-
GO:0045202	synapse	IEA	neuron, Synap, Neurotransmitter, Glial (GO term level: 2)	-
GO:0000164	protein phosphatase type 1 complex	TAS		11278317
GO:0005856	cytoskeleton	IEA		-
GO:0005634	nucleus	IEA		-
GO:0005654	nucleoplasm	IMP		11278317
GO:0005737	cytoplasm	IDA		11278317
GO:0030054	cell junction	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTA1	ACTA \| ASMA \| CFTD \| CFTD1 \| CFTDM \| MPFD \| NEM1 \| NEM2 \| NEM3	actin, alpha 1, skeletal muscle	Reconstituted Complex	BioGRID	12417592
ACTC1	ACTC \| CMD1R \| CMH11	actin, alpha, cardiac muscle 1	-	HPRD	12270929\|12417592
ADRA1A	ADRA1C \| ADRA1L1 \| ALPHA1AAR	adrenergic, alpha-1A-, receptor	-	HPRD	11154706
ADRA2A	ADRA2 \| ADRA2R \| ADRAR \| ALPHA2AAR \| ZNF32	adrenergic, alpha-2A-, receptor	Reconstituted Complex	BioGRID	11154706
ADRA2B	ADRA2L1 \| ADRA2RL1 \| ADRARL1 \| ALPHA2BAR	adrenergic, alpha-2B-, receptor	Reconstituted Complex	BioGRID	11154706
ADRA2C	ADRA2L2 \| ADRA2RL2 \| ADRARL2 \| ALPHA2CAR	adrenergic, alpha-2C-, receptor	Reconstituted Complex	BioGRID	11154706
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	-	HPRD,BioGRID	11278317
CDKN2A	ARF \| CDK4I \| CDKN2 \| CMM2 \| INK4 \| INK4a \| MLM \| MTS1 \| TP16 \| p14 \| p14ARF \| p16 \| p16INK4 \| p16INK4a \| p19	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	SPINO interacts with p14ARF.	BIND	11278317
DCX	DBCN \| DC \| LISX \| SCLH \| XLIS	doublecortin	-	HPRD	14550532
DRD2	D2DR \| D2R	dopamine receptor D2	-	HPRD,BioGRID	10391935
PPP1CA	MGC15877 \| MGC1674 \| PP-1A \| PPP1A	protein phosphatase 1, catalytic subunit, alpha isoform	Affinity Capture-Western Reconstituted Complex	BioGRID	10194355
PPP1CB	MGC3672 \| PP-1B \| PPP1CD	protein phosphatase 1, catalytic subunit, beta isoform	Affinity Capture-Western Reconstituted Complex	BioGRID	10194355
PPP1CC	PPP1G	protein phosphatase 1, catalytic subunit, gamma isoform	Affinity Capture-Western Reconstituted Complex	BioGRID	10194355 \|10391935
PPP1R2	IPP2 \| MGC87148	protein phosphatase 1, regulatory (inhibitor) subunit 2	-	HPRD,BioGRID	12270929
PPP1R9A	FLJ20068 \| KIAA1222 \| NRB1 \| NRBI \| Neurabin-I	protein phosphatase 1, regulatory (inhibitor) subunit 9A	-	HPRD	10514494
PPYR1	MGC116897 \| NPY4-R \| NPY4R \| PP1 \| Y4	pancreatic polypeptide receptor 1	-	HPRD	10194355 \|10391935 \|12270929
RASGRF1	CDC25 \| CDC25L \| GNRP \| GRF1 \| GRF55 \| H-GRF55 \| PP13187	Ras protein-specific guanine nucleotide-releasing factor 1	Affinity Capture-Western	BioGRID	12531897
TGOLN2	MGC14722 \| TGN38 \| TGN46 \| TGN48 \| TGN51 \| TTGN2	trans-golgi network protein 2	-	HPRD,BioGRID	10514494
TIAM1	FLJ36302	T-cell lymphoma invasion and metastasis 1	-	HPRD,BioGRID	12531897

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
LIU SOX4 TARGETS DN	309	191	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP	473	314	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN	110	78	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON	335	181	All SZGR 2.0 genes in this pathway
LEIN LOCALIZED TO DISTAL AND PROXIMAL DENDRITES	17	12	All SZGR 2.0 genes in this pathway
SENGUPTA EBNA1 ANTICORRELATED	173	85	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP	140	94	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-125/351	146	152	1A	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	146	152	1A	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-133	1143	1149	1A	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
				hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
				hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
				hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-148/152	619	626	1A,m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-182	759	765	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-200bc/429	1316	1322	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-216	440	446	m8	hsa-miR-216	UAAUCUCAGCUGGCAACUGUG
miR-335	431	437	1A	hsa-miR-335^brain	UCAAGAGCAAUAACGAAAAAUGU
miR-34/449	311	317	1A	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-346	192	199	1A,m8	hsa-miR-346^brain	UGUCUGCCCGCAUGCCUGCCUCU
miR-96	758	765	1A,m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PPP1R9B