SZGR2

Summary ?

GeneID	8554
Symbol	PIAS1
Synonyms	DDXBP1\|GBP\|GU/RH-II\|ZMIZ3
Description	protein inhibitor of activated STAT 1
Reference	MIM:603566\|HGNC:HGNC:2752\|HPRD:16029\|
Gene type	protein-coding
Map location	15q
Pascal p-value	0.58
Sherlock p-value	0.148
Fetal beta	0.416
DMG	1 (# studies)

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Nishioka_2013	Genome-wide DNA methylation analysis	The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls.	1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg06790275	15	68346669	PIAS1		-0.027	0.57	DMG:Nishioka_2013

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
PHF23	0.82	0.85
TMED9	0.81	0.82
ADRM1	0.79	0.82
TIMM22	0.79	0.79
CTNNBIP1	0.79	0.82
R3HCC1	0.79	0.79
POLR2E	0.79	0.80
SAMM50	0.79	0.80
GRWD1	0.79	0.82
VPS4A	0.79	0.81

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MT-CO2	-0.70	-0.73
AF347015.31	-0.70	-0.71
AF347015.2	-0.68	-0.74
AF347015.8	-0.68	-0.72
MT-CYB	-0.67	-0.71
AF347015.33	-0.67	-0.70
AF347015.15	-0.66	-0.71
AF347015.27	-0.65	-0.70
AF347015.21	-0.64	-0.67
AF347015.9	-0.61	-0.69

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	-	HPRD	11877418
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	Two-hybrid	BioGRID	11117529
AXIN1	AXIN \| MGC52315	axin 1	-	HPRD	12223491
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	CASP8 (caspase-8) interacts with PIAS-1.	BIND	15782135
CEBPA	C/EBP-alpha \| CEBP	CCAAT/enhancer binding protein (C/EBP), alpha	C/EBP-alpha interacts with PIAS1.	BIND	15588942
CEBPE	C/EBP-epsilon \| CRP1	CCAAT/enhancer binding protein (C/EBP), epsilon	C/EBP-epsilon interacts with PIAS1.	BIND	15588942
CEBPE	C/EBP-epsilon \| CRP1	CCAAT/enhancer binding protein (C/EBP), epsilon	-	HPRD	15588942
CSRP2	CRP2 \| LMO5 \| SmLIM	cysteine and glycine-rich protein 2	CRP2 interacts with PIAS1.	BIND	11672422
CSRP2	CRP2 \| LMO5 \| SmLIM	cysteine and glycine-rich protein 2	-	HPRD,BioGRID	11672422
DCLRE1A	KIAA0086 \| PSO2 \| SNM1 \| SNM1A \| hSNM1	DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae)	-	HPRD	15572677
DDX21	DKFZp686F21172 \| GUA \| GURDB \| RH-II/GU \| RH-II/GuA	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	-	HPRD	9177271
DNM1	DNM	dynamin 1	-	HPRD	15123615
DNMT3A	DNMT3A2 \| M.HsaIIIA	DNA (cytosine-5-)-methyltransferase 3 alpha	-	HPRD,BioGRID	14752048
ELK3	ERP \| NET \| SAP2	ELK3, ETS-domain protein (SRF accessory protein 2)	-	HPRD	15580297
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	ER-alpha interacts with PIAS1.	BIND	15666801
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	-	HPRD	15666801
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	-	HPRD	11867732
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	-	HPRD	12393906
NR2F2	ARP1 \| COUP-TFII \| COUPTFB \| MGC117452 \| SVP40 \| TFCOUP2	nuclear receptor subfamily 2, group F, member 2	-	HPRD	15611122 \|15666827
NR3C2	MCR \| MGC133092 \| MLR \| MR	nuclear receptor subfamily 3, group C, member 2	-	HPRD	14500761
PIAS2	MGC102682 \| MIZ1 \| PIASX \| PIASX-ALPHA \| PIASX-BETA \| SIZ2 \| ZMIZ4 \| miz	protein inhibitor of activated STAT, 2	-	HPRD	11877418
PIAS4	FLJ12419 \| MGC35296 \| PIASY \| Piasg \| ZMIZ6	protein inhibitor of activated STAT, 4	-	HPRD	11877418
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	-	HPRD	14500712
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	-	HPRD	15657437
SATB2	FLJ21474 \| FLJ32076 \| KIAA1034 \| MGC119474 \| MGC119477	SATB homeobox 2	-	HPRD	14701874
SP100	DKFZp686E07254 \| FLJ00340 \| FLJ34579	SP100 nuclear antigen	Biochemical Activity	BioGRID	18691969
SP3	DKFZp686O1631 \| SPR-2	Sp3 transcription factor	-	HPRD,BioGRID	12356736
STAB2	DKFZp434E0321 \| FEEL-2 \| FELE-2 \| FELL \| FELL-2 \| FEX2 \| HARE \| STAB-2	stabilin 2	Affinity Capture-Western	BioGRID	14701874
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	-	HPRD,BioGRID	9724754 \|10805787 \|12855578\|10805787
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	-	HPRD	9724754 \|10805787 \|12855578
SUFU	PRO1280 \| SUFUH \| SUFUXL	suppressor of fused homolog (Drosophila)	-	HPRD	14611647
SUMO1	DAP-1 \| GMP1 \| OFC10 \| PIC1 \| SENP2 \| SMT3 \| SMT3C \| SMT3H3 \| SUMO-1 \| UBL1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	SUMO-1 interacts with PIAS1.	BIND	14609633
SUMO1	DAP-1 \| GMP1 \| OFC10 \| PIC1 \| SENP2 \| SMT3 \| SMT3C \| SMT3H3 \| SUMO-1 \| UBL1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	-	HPRD,BioGRID	11583632
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Biochemical Activity Reconstituted Complex Two-hybrid	BioGRID	10380882 \|11583632
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	PIAS1 interacts with p53. This interaction was modeled on a demonstrated interaction between human PIAS1 and p53 from an unspecified species.	BIND	15133049
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD	11583632 \|11788578 \|11867732 \|15133049
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	Ubc9 interacts with PIAS1.	BIND	14609633
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	-	HPRD	12177000
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	Reconstituted Complex Two-hybrid	BioGRID	11583632 \|12356736 \|14609633

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG UBIQUITIN MEDIATED PROTEOLYSIS	138	98	All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY	155	105	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
ST JAK STAT PATHWAY	9	8	All SZGR 2.0 genes in this pathway
PID AR PATHWAY	61	46	All SZGR 2.0 genes in this pathway
PID TCPTP PATHWAY	43	33	All SZGR 2.0 genes in this pathway
PID RANBP2 PATHWAY	11	11	All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY	40	34	All SZGR 2.0 genes in this pathway
PID IL6 7 PATHWAY	47	40	All SZGR 2.0 genes in this pathway
PID HEDGEHOG GLI PATHWAY	48	35	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF IFNG SIGNALING	14	10	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON GAMMA SIGNALING	63	48	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING	159	116	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP	332	228	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO ANDROGEN UP	29	21	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO FORSKOLIN DN	9	7	All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN	384	230	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP	404	246	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN	805	505	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP	552	347	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP	487	286	All SZGR 2.0 genes in this pathway
AMIT DELAYED EARLY GENES	18	15	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 40 HELA	42	29	All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN UP	86	61	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE DN	87	59	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C1	72	45	All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE	261	166	All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN	264	168	All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN	373	196	All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED	728	415	All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP	125	89	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B	549	316	All SZGR 2.0 genes in this pathway

Gene Page: PIAS1