Gene Page: TNK1
Summary ?
| GeneID | 8711 |
| Symbol | TNK1 |
| Synonyms | - |
| Description | tyrosine kinase, non-receptor, 1 |
| Reference | MIM:608076|HGNC:HGNC:11940|Ensembl:ENSG00000174292|HPRD:09730|Vega:OTTHUMG00000178174 |
| Gene type | protein-coding |
| Map location | 17p13.1 |
| Pascal p-value | 0.038 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | TNK1 | 8711 | 0.05 | trans | ||
| rs7584986 | chr2 | 184111432 | TNK1 | 8711 | 0.06 | trans | ||
| rs10008800 | chr4 | 5773180 | TNK1 | 8711 | 0.05 | trans | ||
| rs10491487 | chr5 | 80323367 | TNK1 | 8711 | 0.03 | trans | ||
| rs9364293 | chr6 | 169199078 | TNK1 | 8711 | 0.06 | trans | ||
| rs16955618 | chr15 | 29937543 | TNK1 | 8711 | 4.485E-4 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| DIRAS3 | 0.62 | 0.47 |
| FEZF1 | 0.62 | 0.30 |
| AC009163.1 | 0.60 | 0.41 |
| AVP | 0.60 | -0.12 |
| PMCH | 0.60 | 0.32 |
| DNALI1 | 0.59 | 0.43 |
| HCRT | 0.59 | 0.16 |
| C2orf70 | 0.59 | 0.32 |
| OXT | 0.59 | -0.08 |
| TMEM146 | 0.59 | 0.38 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SPARCL1 | -0.20 | -0.32 |
| SOHLH1 | -0.20 | -0.41 |
| ITPKA | -0.19 | -0.31 |
| CABP1 | -0.19 | -0.38 |
| GRASP | -0.18 | -0.30 |
| TRPV6 | -0.18 | -0.25 |
| ALDH1A1 | -0.18 | -0.31 |
| EPHX4 | -0.18 | -0.26 |
| NNMT | -0.18 | -0.31 |
| SLC26A4 | -0.18 | -0.17 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP | 180 | 114 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF ICP WITH H3K27ME3 | 206 | 108 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| RATTENBACHER BOUND BY CELF1 | 467 | 251 | All SZGR 2.0 genes in this pathway |