Summary ?
GeneID8915
SymbolBCL10
SynonymsCARMEN|CIPER|CLAP|IMD37|c-E10|mE10
DescriptionB-cell CLL/lymphoma 10
ReferenceMIM:603517|HGNC:HGNC:989|Ensembl:ENSG00000142867|HPRD:04625|Vega:OTTHUMG00000009965
Gene typeprotein-coding
Map location1p22
Pascal p-value0.037
eGenePutamen basal ganglia
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs34658102185014117BCL10ENSG00000142867.81.23163E-60.03728656gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003713transcription coactivator activityIDA15207693 
GO:0008022protein C-terminus bindingIPI11053425 
GO:0031625ubiquitin protein ligase bindingIPI16395405 
GO:0051059NF-kappaB bindingIDA16280327 
GO:0019209kinase activator activityIDA15125833 
GO:0043130ubiquitin bindingIDA15082780 
GO:0043422protein kinase B bindingIPI16280327 
GO:0043621protein self-associationIPI15125833 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002237response to molecule of bacterial originIEP16831874 
GO:0002250adaptive immune responseTAS16831874 
GO:0002906negative regulation of mature B cell apoptosisIDA15878976 
GO:0002224toll-like receptor signaling pathwayIC16831874 
GO:0001843neural tube closureISS11163238 
GO:0016064immunoglobulin mediated immune responseIEA-
GO:0008219cell deathIDA10400625 
GO:0006968cellular defense responseIEA-
GO:0009620response to fungusIEA-
GO:0042981regulation of apoptosisIEA-
GO:0042226interleukin-6 biosynthetic processNAS16647297 
GO:0042327positive regulation of phosphorylationIDA15125833 
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA10400625 |14695475 
GO:0042109lymphotoxin A biosynthetic processNAS16647297 
GO:0050870positive regulation of T cell activationIEA-
GO:0050856regulation of T cell receptor signaling pathwayIEA-
GO:0031398positive regulation of protein ubiquitinationIDA14695475 
GO:0032765positive regulation of mast cell cytokine productionNAS16647297 
GO:0051260protein homooligomerizationISS16831874 
GO:0051260protein homooligomerizationTAS16831874 
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
GO:0045893positive regulation of transcription, DNA-dependentIDA15207693 
GO:0045087innate immune responseIEP16831874 
GO:0045786negative regulation of cell cycleIEA-
GO:0045416positive regulation of interleukin-8 biosynthetic processIMP17095757 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042101T cell receptor complexIDASynap (GO term level: 8)12154360 
GO:0005829cytosolEXP15122200 |15125833 |17468049 
GO:0005829cytosolIDA12154360 
GO:0005622intracellularIEA-
GO:0005634nucleusIDA16280327 
GO:0005737cytoplasmIDA11021819 |11053425 |11278692 
|15082780 
GO:0005764lysosomeIDA15082780 
GO:0048471perinuclear region of cytoplasmIDA16127295 
GO:0032449CBM complexNAS15125833 
GO:0045121membrane raftIEA-
GO:0046696lipopolysaccharide receptor complexIDA16831874 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCL10CARMEN | CIPER | CLAP | c-E10 | mE10B-cell CLL/lymphoma 10Bcl10 interacts with itself.BIND15125833 
C9orf89BinCARD | MGC110898 | MGC11115 | bA370F5.1chromosome 9 open reading frame 89-HPRD,BioGRID15637807 
CARD10BIMP1 | CARMA3 | MGC142219caspase recruitment domain family, member 10-HPRD,BioGRID11259443 |11387339 
CARD10BIMP1 | CARMA3 | MGC142219caspase recruitment domain family, member 10CARD10 interacts with BCL10.BIND11259443 
CARD11BIMP3 | CARMA1 | MGC133069caspase recruitment domain family, member 11-HPRD,BioGRID11278692 
CARD11BIMP3 | CARMA1 | MGC133069caspase recruitment domain family, member 11CARD11 interacts with BCL10.BIND11278692 
CARD14BIMP2 | CARMA2caspase recruitment domain family, member 14-HPRD,BioGRID11278692 
CARD14BIMP2 | CARMA2caspase recruitment domain family, member 14CARD14 interacts with BCL10.BIND11278692 
CARD9hCARD9caspase recruitment domain family, member 9-HPRD,BioGRID11053425 
CARD9hCARD9caspase recruitment domain family, member 9CARD9 interacts with BCL10.BIND11053425 
CASP9APAF-3 | APAF3 | CASPASE-9c | ICE-LAP6 | MCH6caspase 9, apoptosis-related cysteine peptidase-HPRD10187815 
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinase-HPRD11113112 
HIST1H2BCH2B.1 | H2B/l | H2BFL | MGC104246 | dJ221C16.3histone cluster 1, H2bcAffinity Capture-MSBioGRID17353931 
IKBKGAMCBX1 | FIP-3 | FIP3 | Fip3p | IKK-gamma | IP | IP1 | IP2 | IPD2 | NEMOinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaBcl10 interacts with NEMO.BIND14695475 
KRT33BHA3II | Ha-3II | KRTHA3A | KRTHA3B | hHa3-IIkeratin 33BAffinity Capture-MSBioGRID17353931 
MALT1DKFZp434L132 | MLT | MLT1mucosa associated lymphoid tissue lymphoma translocation gene 1-HPRD,BioGRID11090634 
MALT1DKFZp434L132 | MLT | MLT1mucosa associated lymphoid tissue lymphoma translocation gene 1Bcl10 interacts with paracaspase.BIND14695475 
NLRC4CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAFNLR family, CARD domain containing 4-HPRD,BioGRID11472070 
NLRC4CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAFNLR family, CARD domain containing 4CARD12 (CLAN) interacts with Bcl10. This interaction was modelled on a demonstrated interaction between human CARD12 and Bcl10 from an unspecified species.BIND11472070 
TNFRSF10AAPO2 | CD261 | DR4 | MGC9365 | TRAILR-1 | TRAILR1tumor necrosis factor receptor superfamily, member 10a-HPRD,BioGRID10400625 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1ATwo-hybridBioGRID10400625 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domain-HPRD,BioGRID10400625 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2-HPRD,BioGRID10753917 
UBE2NMGC131857 | MGC8489 | UBC13 | UbcH-benubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)Bcl10 interacts with UBC13.BIND14695475 
UBE2V2DDVIT1 | DDVit-1 | EDAF-1 | EDPF-1 | EDPF1 | MMS2 | UEV-2 | UEV2ubiquitin-conjugating enzyme E2 variant 2Bcl10 interacts with MMS2.BIND14695475 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG T CELL RECEPTOR SIGNALING PATHWAY 10889All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY 7556All SZGR 2.0 genes in this pathway
SA PROGRAMMED CELL DEATH 129All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY 6550All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 6651All SZGR 2.0 genes in this pathway
PID NFKAPPAB CANONICAL PATHWAY 2320All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY 5342All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 9766All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS 6443All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 12690All SZGR 2.0 genes in this pathway
REACTOME TCR SIGNALING 5446All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM TCR SIGNALING 3732All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN 13686All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS UP 13794All SZGR 2.0 genes in this pathway
BILBAN B CLL LPL UP 6339All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP 176123All SZGR 2.0 genes in this pathway
NAGASHIMA EGF SIGNALING UP 5840All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP 5540All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK TARGETS 1815All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP 8858All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2 12792All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS 5845All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM1 229137All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156106All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A UP 142104All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 120 HELA 6947All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 120 MCF10A 4328All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN 8567All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION UP 14083All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 VS CD2 DN 5235All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO CANTHARIDIN UP 1912All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN WITHOUT MGMT 48HR UP 1813All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP 223132All SZGR 2.0 genes in this pathway
TAYLOR METHYLATED IN ACUTE LYMPHOBLASTIC LEUKEMIA 7752All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE DN 204114All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA PR DN 4434All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516308All SZGR 2.0 genes in this pathway