Gene Page: BCL10
Summary ?
GeneID | 8915 |
Symbol | BCL10 |
Synonyms | CARMEN|CIPER|CLAP|IMD37|c-E10|mE10 |
Description | B-cell CLL/lymphoma 10 |
Reference | MIM:603517|HGNC:HGNC:989|Ensembl:ENSG00000142867|HPRD:04625|Vega:OTTHUMG00000009965 |
Gene type | protein-coding |
Map location | 1p22 |
Pascal p-value | 0.037 |
eGene | Putamen basal ganglia Meta |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs34658102 | 1 | 85014117 | BCL10 | ENSG00000142867.8 | 1.23163E-6 | 0.03 | 728656 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0003713 | transcription coactivator activity | IDA | 15207693 | |
GO:0008022 | protein C-terminus binding | IPI | 11053425 | |
GO:0031625 | ubiquitin protein ligase binding | IPI | 16395405 | |
GO:0051059 | NF-kappaB binding | IDA | 16280327 | |
GO:0019209 | kinase activator activity | IDA | 15125833 | |
GO:0043130 | ubiquitin binding | IDA | 15082780 | |
GO:0043422 | protein kinase B binding | IPI | 16280327 | |
GO:0043621 | protein self-association | IPI | 15125833 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0002237 | response to molecule of bacterial origin | IEP | 16831874 | |
GO:0002250 | adaptive immune response | TAS | 16831874 | |
GO:0002906 | negative regulation of mature B cell apoptosis | IDA | 15878976 | |
GO:0002224 | toll-like receptor signaling pathway | IC | 16831874 | |
GO:0001843 | neural tube closure | ISS | 11163238 | |
GO:0016064 | immunoglobulin mediated immune response | IEA | - | |
GO:0008219 | cell death | IDA | 10400625 | |
GO:0006968 | cellular defense response | IEA | - | |
GO:0009620 | response to fungus | IEA | - | |
GO:0042981 | regulation of apoptosis | IEA | - | |
GO:0042226 | interleukin-6 biosynthetic process | NAS | 16647297 | |
GO:0042327 | positive regulation of phosphorylation | IDA | 15125833 | |
GO:0051092 | positive regulation of NF-kappaB transcription factor activity | IDA | 10400625 |14695475 | |
GO:0042109 | lymphotoxin A biosynthetic process | NAS | 16647297 | |
GO:0050870 | positive regulation of T cell activation | IEA | - | |
GO:0050856 | regulation of T cell receptor signaling pathway | IEA | - | |
GO:0031398 | positive regulation of protein ubiquitination | IDA | 14695475 | |
GO:0032765 | positive regulation of mast cell cytokine production | NAS | 16647297 | |
GO:0051260 | protein homooligomerization | ISS | 16831874 | |
GO:0051260 | protein homooligomerization | TAS | 16831874 | |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | IEP | 12761501 | |
GO:0045893 | positive regulation of transcription, DNA-dependent | IDA | 15207693 | |
GO:0045087 | innate immune response | IEP | 16831874 | |
GO:0045786 | negative regulation of cell cycle | IEA | - | |
GO:0045416 | positive regulation of interleukin-8 biosynthetic process | IMP | 17095757 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0042101 | T cell receptor complex | IDA | Synap (GO term level: 8) | 12154360 |
GO:0005829 | cytosol | EXP | 15122200 |15125833 |17468049 | |
GO:0005829 | cytosol | IDA | 12154360 | |
GO:0005622 | intracellular | IEA | - | |
GO:0005634 | nucleus | IDA | 16280327 | |
GO:0005737 | cytoplasm | IDA | 11021819 |11053425 |11278692 |15082780 | |
GO:0005764 | lysosome | IDA | 15082780 | |
GO:0048471 | perinuclear region of cytoplasm | IDA | 16127295 | |
GO:0032449 | CBM complex | NAS | 15125833 | |
GO:0045121 | membrane raft | IEA | - | |
GO:0046696 | lipopolysaccharide receptor complex | IDA | 16831874 |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
BCL10 | CARMEN | CIPER | CLAP | c-E10 | mE10 | B-cell CLL/lymphoma 10 | Bcl10 interacts with itself. | BIND | 15125833 |
C9orf89 | BinCARD | MGC110898 | MGC11115 | bA370F5.1 | chromosome 9 open reading frame 89 | - | HPRD,BioGRID | 15637807 |
CARD10 | BIMP1 | CARMA3 | MGC142219 | caspase recruitment domain family, member 10 | - | HPRD,BioGRID | 11259443 |11387339 |
CARD10 | BIMP1 | CARMA3 | MGC142219 | caspase recruitment domain family, member 10 | CARD10 interacts with BCL10. | BIND | 11259443 |
CARD11 | BIMP3 | CARMA1 | MGC133069 | caspase recruitment domain family, member 11 | - | HPRD,BioGRID | 11278692 |
CARD11 | BIMP3 | CARMA1 | MGC133069 | caspase recruitment domain family, member 11 | CARD11 interacts with BCL10. | BIND | 11278692 |
CARD14 | BIMP2 | CARMA2 | caspase recruitment domain family, member 14 | - | HPRD,BioGRID | 11278692 |
CARD14 | BIMP2 | CARMA2 | caspase recruitment domain family, member 14 | CARD14 interacts with BCL10. | BIND | 11278692 |
CARD9 | hCARD9 | caspase recruitment domain family, member 9 | - | HPRD,BioGRID | 11053425 |
CARD9 | hCARD9 | caspase recruitment domain family, member 9 | CARD9 interacts with BCL10. | BIND | 11053425 |
CASP9 | APAF-3 | APAF3 | CASPASE-9c | ICE-LAP6 | MCH6 | caspase 9, apoptosis-related cysteine peptidase | - | HPRD | 10187815 |
CHUK | IKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16 | conserved helix-loop-helix ubiquitous kinase | - | HPRD | 11113112 |
HIST1H2BC | H2B.1 | H2B/l | H2BFL | MGC104246 | dJ221C16.3 | histone cluster 1, H2bc | Affinity Capture-MS | BioGRID | 17353931 |
IKBKG | AMCBX1 | FIP-3 | FIP3 | Fip3p | IKK-gamma | IP | IP1 | IP2 | IPD2 | NEMO | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | Bcl10 interacts with NEMO. | BIND | 14695475 |
KRT33B | HA3II | Ha-3II | KRTHA3A | KRTHA3B | hHa3-II | keratin 33B | Affinity Capture-MS | BioGRID | 17353931 |
MALT1 | DKFZp434L132 | MLT | MLT1 | mucosa associated lymphoid tissue lymphoma translocation gene 1 | - | HPRD,BioGRID | 11090634 |
MALT1 | DKFZp434L132 | MLT | MLT1 | mucosa associated lymphoid tissue lymphoma translocation gene 1 | Bcl10 interacts with paracaspase. | BIND | 14695475 |
NLRC4 | CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAF | NLR family, CARD domain containing 4 | - | HPRD,BioGRID | 11472070 |
NLRC4 | CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAF | NLR family, CARD domain containing 4 | CARD12 (CLAN) interacts with Bcl10. This interaction was modelled on a demonstrated interaction between human CARD12 and Bcl10 from an unspecified species. | BIND | 11472070 |
TNFRSF10A | APO2 | CD261 | DR4 | MGC9365 | TRAILR-1 | TRAILR1 | tumor necrosis factor receptor superfamily, member 10a | - | HPRD,BioGRID | 10400625 |
TNFRSF1A | CD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60 | tumor necrosis factor receptor superfamily, member 1A | Two-hybrid | BioGRID | 10400625 |
TRADD | Hs.89862 | MGC11078 | TNFRSF1A-associated via death domain | - | HPRD,BioGRID | 10400625 |
TRAF2 | MGC:45012 | TRAP | TRAP3 | TNF receptor-associated factor 2 | - | HPRD,BioGRID | 10753917 |
UBE2N | MGC131857 | MGC8489 | UBC13 | UbcH-ben | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) | Bcl10 interacts with UBC13. | BIND | 14695475 |
UBE2V2 | DDVIT1 | DDVit-1 | EDAF-1 | EDPF-1 | EDPF1 | MMS2 | UEV-2 | UEV2 | ubiquitin-conjugating enzyme E2 variant 2 | Bcl10 interacts with MMS2. | BIND | 14695475 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG T CELL RECEPTOR SIGNALING PATHWAY | 108 | 89 | All SZGR 2.0 genes in this pathway |
KEGG B CELL RECEPTOR SIGNALING PATHWAY | 75 | 56 | All SZGR 2.0 genes in this pathway |
SA PROGRAMMED CELL DEATH | 12 | 9 | All SZGR 2.0 genes in this pathway |
PID BCR 5PATHWAY | 65 | 50 | All SZGR 2.0 genes in this pathway |
PID TCR PATHWAY | 66 | 51 | All SZGR 2.0 genes in this pathway |
PID NFKAPPAB CANONICAL PATHWAY | 23 | 20 | All SZGR 2.0 genes in this pathway |
PID CD8 TCR PATHWAY | 53 | 42 | All SZGR 2.0 genes in this pathway |
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | 97 | 66 | All SZGR 2.0 genes in this pathway |
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | 64 | 43 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR | 126 | 90 | All SZGR 2.0 genes in this pathway |
REACTOME TCR SIGNALING | 54 | 46 | All SZGR 2.0 genes in this pathway |
REACTOME DOWNSTREAM TCR SIGNALING | 37 | 32 | All SZGR 2.0 genes in this pathway |
REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
REACTOME ADAPTIVE IMMUNE SYSTEM | 539 | 350 | All SZGR 2.0 genes in this pathway |
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN | 136 | 86 | All SZGR 2.0 genes in this pathway |
LIU SOX4 TARGETS UP | 137 | 94 | All SZGR 2.0 genes in this pathway |
BILBAN B CLL LPL UP | 63 | 39 | All SZGR 2.0 genes in this pathway |
NAGASHIMA NRG1 SIGNALING UP | 176 | 123 | All SZGR 2.0 genes in this pathway |
NAGASHIMA EGF SIGNALING UP | 58 | 40 | All SZGR 2.0 genes in this pathway |
ENK UV RESPONSE EPIDERMIS DN | 508 | 354 | All SZGR 2.0 genes in this pathway |
LAU APOPTOSIS CDKN2A UP | 55 | 40 | All SZGR 2.0 genes in this pathway |
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
SCHEIDEREIT IKK TARGETS | 18 | 15 | All SZGR 2.0 genes in this pathway |
HUMMERICH SKIN CANCER PROGRESSION UP | 88 | 58 | All SZGR 2.0 genes in this pathway |
RASHI RESPONSE TO IONIZING RADIATION 2 | 127 | 92 | All SZGR 2.0 genes in this pathway |
SCHEIDEREIT IKK INTERACTING PROTEINS | 58 | 45 | All SZGR 2.0 genes in this pathway |
SHETH LIVER CANCER VS TXNIP LOSS PAM1 | 229 | 137 | All SZGR 2.0 genes in this pathway |
GROSS HYPOXIA VIA ELK3 DN | 156 | 106 | All SZGR 2.0 genes in this pathway |
GROSS HYPOXIA VIA ELK3 AND HIF1A UP | 142 | 104 | All SZGR 2.0 genes in this pathway |
NUYTTEN NIPP1 TARGETS UP | 769 | 437 | All SZGR 2.0 genes in this pathway |
NUYTTEN EZH2 TARGETS UP | 1037 | 673 | All SZGR 2.0 genes in this pathway |
AMIT EGF RESPONSE 120 HELA | 69 | 47 | All SZGR 2.0 genes in this pathway |
AMIT EGF RESPONSE 120 MCF10A | 43 | 28 | All SZGR 2.0 genes in this pathway |
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN | 85 | 67 | All SZGR 2.0 genes in this pathway |
ALCALAY AML BY NPM1 LOCALIZATION UP | 140 | 83 | All SZGR 2.0 genes in this pathway |
ZHAN MULTIPLE MYELOMA CD1 VS CD2 DN | 52 | 35 | All SZGR 2.0 genes in this pathway |
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP | 314 | 201 | All SZGR 2.0 genes in this pathway |
ZHANG RESPONSE TO CANTHARIDIN UP | 19 | 12 | All SZGR 2.0 genes in this pathway |
BANDRES RESPONSE TO CARMUSTIN WITHOUT MGMT 48HR UP | 18 | 13 | All SZGR 2.0 genes in this pathway |
MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
CHEN HOXA5 TARGETS 9HR UP | 223 | 132 | All SZGR 2.0 genes in this pathway |
TAYLOR METHYLATED IN ACUTE LYMPHOBLASTIC LEUKEMIA | 77 | 52 | All SZGR 2.0 genes in this pathway |
GRESHOCK CANCER COPY NUMBER UP | 323 | 240 | All SZGR 2.0 genes in this pathway |
CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
ROME INSULIN TARGETS IN MUSCLE DN | 204 | 114 | All SZGR 2.0 genes in this pathway |
ZHAN MULTIPLE MYELOMA PR DN | 44 | 34 | All SZGR 2.0 genes in this pathway |
PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | All SZGR 2.0 genes in this pathway |
BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |
RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF | 516 | 308 | All SZGR 2.0 genes in this pathway |