Gene Page: CCNT1

Summary ?
GeneID904
SymbolCCNT1
SynonymsCCNT|CYCT1|HIVE1
Descriptioncyclin T1
ReferenceMIM:143055|HGNC:HGNC:1599|Ensembl:ENSG00000129315|HPRD:03938|Vega:OTTHUMG00000170393
Gene typeprotein-coding
Map location12q13.11
Pascal p-value0.386
Sherlock p-value0.562
Fetal beta0.954
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1
ExpressionMeta-analysis of gene expressionP value: 1.606 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg221035851249110427CCNT1-0.0320.46DMG:Nishioka_2013

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs9637082chr2121213235CCNT19040.14trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIDA16109376 
GO:0005515protein bindingIPI12944466 
GO:0017069snRNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000079regulation of cyclin-dependent protein kinase activityTAS9499409 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0006468protein amino acid phosphorylationIPI16109376 
GO:0006366transcription from RNA polymerase II promoterTAS9499409 
GO:0007049cell cycleIEA-
GO:0051301cell divisionIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA12944466 
GO:0005654nucleoplasmEXP7853496 |12676794 
GO:0005730nucleolusIDA16109376 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AFF4AF5Q31 | MCEF | MGC75036AF4/FMR2 family, member 4-HPRD,BioGRID12065898 
AHR-aryl hydrocarbon receptor-HPRD,BioGRID12917420 
CCNKCPR4 | MGC9113cyclin Kin vitro
in vivo		BioGRID10574912 
CDK9C-2k | CDC2L4 | CTK1 | PITALRE | TAKcyclin-dependent kinase 9-HPRD9872325 |10465067 
|10617616 |11145967 
|11689688 |11713532 
|11713533 |12115727 
|12894230 |14627702 
|15528190 
CDK9C-2k | CDC2L4 | CTK1 | PITALRE | TAKcyclin-dependent kinase 9CyclinT1 interacts with Cdk9.BIND9499409 
CDK9C-2k | CDC2L4 | CTK1 | PITALRE | TAKcyclin-dependent kinase 9CycT1 interacts with CDK9. This interaction was modeled on a demonstrated interaction between CycT1 from an unspecified species and human CDK9.BIND15546612 
CDK9C-2k | CDC2L4 | CTK1 | PITALRE | TAKcyclin-dependent kinase 9Affinity Capture-Western
in vitro
in vivo
Phenotypic Suppression
Reconstituted Complex
Two-hybrid		BioGRID9499409 |10656684 
|10958691 |11689688 
|12588988 |12832472 
|12944466 |15107825 
CDK9C-2k | CDC2L4 | CTK1 | PITALRE | TAKcyclin-dependent kinase 9Cyclin T1 interacts with CDK9.BIND12588988 
CDK9C-2k | CDC2L4 | CTK1 | PITALRE | TAKcyclin-dependent kinase 9-HPRD9499409 |10958691 
GRIPAP1DKFZp434P0630 | GRASP-1 | KIAA1167 | MGC126593 | MGC126595GRIP1 associated protein 1in vitro
in vivo		BioGRID11704662 
GRNGEP | GP88 | PCDGF | PEPI | PGRNgranulin-HPRD,BioGRID12588988 
GRNGEP | GP88 | PCDGF | PEPI | PGRNgranulinCyclin T1 interacts with granulin.BIND12588988 
HEXIM1CLP1 | EDG1 | FLJ13562 | HIS1 | MAQ1hexamethylene bis-acetamide inducible 1-HPRD,BioGRID12832472 
HTATSF1TAT-SF1 | dJ196E23.2HIV-1 Tat specific factor 1-HPRD,BioGRID10913173 |11780068 
MDFICHICMyoD family inhibitor domain containingAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID12944466 
MYBL2B-MYB | BMYB | MGC15600v-myb myeloblastosis viral oncogene homolog (avian)-like 2Phenotypic SuppressionBioGRID10656684 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)-HPRD,BioGRID12944920 
NCOA2GRIP1 | KAT13C | MGC138808 | NCoA-2 | TIF2nuclear receptor coactivator 2Cyclin T1 interacts with GRIP1.BIND11704662 
NUFIP1NUFIP | bA540M5.1nuclear fragile X mental retardation protein interacting protein 1Affinity Capture-Western
Reconstituted Complex		BioGRID15107825 
NUFIP1NUFIP | bA540M5.1nuclear fragile X mental retardation protein interacting protein 1CyclinT1 interacts with NUFIP.BIND15107825 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD,BioGRID12727882 
PURAPUR-ALPHA | PUR1 | PURALPHApurine-rich element binding protein A-HPRD,BioGRID11730934 
SKP2FBL1 | FBXL1 | FLB1 | MGC1366S-phase kinase-associated protein 2 (p45)-HPRD11689688 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 2717All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 3826All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY 352181All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION 10554All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION 210127All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX 4519All SZGR 2.0 genes in this pathway
REACTOME ELONGATION ARREST AND RECOVERY 3214All SZGR 2.0 genes in this pathway
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS 6132All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME HIV LIFE CYCLE 12569All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 13281All SZGR 2.0 genes in this pathway
REACTOME LATE PHASE OF HIV LIFE CYCLE 10461All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 6342All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357212All SZGR 2.0 genes in this pathway
NOUZOVA TRETINOIN AND H4 ACETYLATION 14385All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND H2O2 3929All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A UP 8152All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393244All SZGR 2.0 genes in this pathway
WHITEFORD PEDIATRIC CANCER MARKERS 11663All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS DN 10864All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668419All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE MIDDLE 9856All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN 180116All SZGR 2.0 genes in this pathway
KOHOUTEK CCNT1 TARGETS 5026All SZGR 2.0 genes in this pathway
LE NEURONAL DIFFERENTIATION DN 1916All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516308All SZGR 2.0 genes in this pathway