Gene Page: CD3E

Summary ?
GeneID916
SymbolCD3E
SynonymsIMD18|T3E|TCRE
DescriptionCD3e molecule
ReferenceMIM:186830|HGNC:HGNC:1674|Ensembl:ENSG00000198851|HPRD:08923|Vega:OTTHUMG00000166968
Gene typeprotein-coding
Map location11q23
Pascal p-value0.036
Fetal beta0.047
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 3
GSMA_IGenome scan meta-analysisPsr: 0.006 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg0772887411118213272CD3E6.1E-5-5.331DMG:vanEijk_2014
cg2484124411118213330CD3E7.77E-5-5.77DMG:vanEijk_2014
cg2461219811118175631CD3E1.39E-5-6.459DMG:vanEijk_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs621071chr1182682810CD3E9160.11trans
rs2190759chr1755794698CD3E9160.19trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
EXTL10.710.67
MAST30.700.63
ANXA110.690.68
EPB490.680.61
SYNPO0.680.66
KCNK10.680.67
DGKZ0.680.65
ADRB10.670.59
CAMK2A0.670.67
RASAL10.670.63
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TUBB2B-0.43-0.52
GTF3C6-0.43-0.47
FAM36A-0.43-0.46
C9orf46-0.43-0.54
BCL7C-0.42-0.57
DYNLT1-0.42-0.61
KIAA1949-0.42-0.47
EXOSC8-0.42-0.53
PDE9A-0.42-0.52
YBX1-0.42-0.50

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005057receptor signaling protein activityTAS1370449 
GO:0004888transmembrane receptor activityNAS9485181 
GO:0017124SH3 domain bindingIPI12110186 
GO:0030159receptor signaling complex scaffold activityNAS9886373 
GO:0042608T cell receptor bindingNAS11186279 
GO:0019901protein kinase bindingNAS12110186 
GO:0046982protein heterodimerization activityIPI9485181 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayTAS8530500 
GO:0007172signal complex assemblyTAS8490660 
GO:0006461protein complex assemblyNAS9886373 
GO:0042981regulation of apoptosisNAS12567487 
GO:0042110T cell activationNAS12110186 
GO:0042102positive regulation of T cell proliferationIMP12110186 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042101T cell receptor complexNASSynap (GO term level: 8)9485181 
GO:0009897external side of plasma membraneIDA11390434 
GO:0005886plasma membraneEXP11048639 |11827988 |15489916 
|17652306 
GO:0005886plasma membraneIDA11390434 
GO:0005887integral to plasma membraneNAS9485181 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD247CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZCD247 molecule-HPRD9485181 
CD3EAPASE-1 | CAST | MGC118851 | PAF49CD3e molecule, epsilon associated proteinAffinity Capture-Western
Reconstituted Complex		BioGRID10373416 
CD3GCD3-GAMMA | FLJ17620 | FLJ17664 | FLJ79544 | FLJ94613 | MGC138597 | T3GCD3g molecule, gamma (CD3-TCR complex)Affinity Capture-WesternBioGRID9582308 
CD79BB29 | IGBCD79b molecule, immunoglobulin-associated beta-HPRD7541024 
JAK3JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)Affinity Capture-WesternBioGRID11349123 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD11855827 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1Reconstituted ComplexBioGRID12110186 
NCK2GRB4 | NCKbetaNCK adaptor protein 2-HPRD,BioGRID12110186 
NCLC23 | FLJ45706nucleolinReconstituted ComplexBioGRID11115514 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD,BioGRID9312149 |11689561 
|11855827 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD11855827 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinaseReconstituted ComplexBioGRID7761456 
TOP2BTOPIIB | top2betatopoisomerase (DNA) II beta 180kDa-HPRD,BioGRID8626450 
TRA@FLJ22602 | MGC117436 | MGC22624 | MGC23964 | MGC71411 | TCRA | TCRD | TRAT cell receptor alpha locus-HPRD9485181 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDaReconstituted ComplexBioGRID7761456 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDa-HPRD11855827 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG HEMATOPOIETIC CELL LINEAGE 8860All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 10889All SZGR 2.0 genes in this pathway
KEGG PRIMARY IMMUNODEFICIENCY 3528All SZGR 2.0 genes in this pathway
BIOCARTA CSK PATHWAY 2420All SZGR 2.0 genes in this pathway
BIOCARTA CTL PATHWAY 1511All SZGR 2.0 genes in this pathway
BIOCARTA TCAPOPTOSIS PATHWAY 118All SZGR 2.0 genes in this pathway
BIOCARTA IL17 PATHWAY 1712All SZGR 2.0 genes in this pathway
BIOCARTA IL12 PATHWAY 2317All SZGR 2.0 genes in this pathway
BIOCARTA TCRA PATHWAY 1310All SZGR 2.0 genes in this pathway
BIOCARTA NO2IL12 PATHWAY 1714All SZGR 2.0 genes in this pathway
BIOCARTA TOB1 PATHWAY 2114All SZGR 2.0 genes in this pathway
BIOCARTA STATHMIN PATHWAY 1917All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY 4937All SZGR 2.0 genes in this pathway
BIOCARTA TCYTOTOXIC PATHWAY 1411All SZGR 2.0 genes in this pathway
BIOCARTA THELPER PATHWAY 1411All SZGR 2.0 genes in this pathway
BIOCARTA CTLA4 PATHWAY 2118All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 6651All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY 6354All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY 5342All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 10278All SZGR 2.0 genes in this pathway
PID IL23 PATHWAY 3730All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY 6556All SZGR 2.0 genes in this pathway
PID IL12 STAT4 PATHWAY 3329All SZGR 2.0 genes in this pathway
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 7037All SZGR 2.0 genes in this pathway
REACTOME TCR SIGNALING 5446All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM TCR SIGNALING 3732All SZGR 2.0 genes in this pathway
REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 1615All SZGR 2.0 genes in this pathway
REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE 1414All SZGR 2.0 genes in this pathway
REACTOME GENERATION OF SECOND MESSENGER MOLECULES 2725All SZGR 2.0 genes in this pathway
REACTOME PD1 SIGNALING 1814All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY 6348All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN UP 184125All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261153All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
FERRANDO TAL1 NEIGHBORS 2115All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
SHIPP DLBCL VS FOLLICULAR LYMPHOMA DN 4528All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN 7657All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION UP 8767All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
MOREIRA RESPONSE TO TSA DN 1816All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259185All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252155All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
ZHAN VARIABLE EARLY DIFFERENTIATION GENES UP 159All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253192All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718401All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP 221120All SZGR 2.0 genes in this pathway