Gene Page: CD33
Summary ?
| GeneID | 945 |
| Symbol | CD33 |
| Synonyms | SIGLEC-3|SIGLEC3|p67 |
| Description | CD33 molecule |
| Reference | MIM:159590|HGNC:HGNC:1659|Ensembl:ENSG00000105383|HPRD:01165|Vega:OTTHUMG00000182891 |
| Gene type | protein-coding |
| Map location | 19q13.3 |
| Pascal p-value | 0.396 |
| Fetal beta | -0.617 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10239544 | chr7 | 66897868 | CD33 | 945 | 0.19 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PICALM | 0.94 | 0.95 |
| AC012621.2 | 0.92 | 0.93 |
| GTF2A1 | 0.92 | 0.92 |
| ZNF451 | 0.91 | 0.94 |
| PPP1R15B | 0.91 | 0.92 |
| MTDH | 0.90 | 0.93 |
| AP1GBP1 | 0.90 | 0.92 |
| CUL4B | 0.90 | 0.92 |
| DCTN4 | 0.90 | 0.91 |
| SESTD1 | 0.90 | 0.92 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.66 | -0.74 |
| AF347015.31 | -0.65 | -0.72 |
| IFI27 | -0.65 | -0.72 |
| FXYD1 | -0.65 | -0.72 |
| AF347015.21 | -0.65 | -0.75 |
| CXCL14 | -0.64 | -0.73 |
| HIGD1B | -0.63 | -0.71 |
| AF347015.8 | -0.62 | -0.71 |
| MT-CYB | -0.61 | -0.68 |
| AF347015.33 | -0.61 | -0.67 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG HEMATOPOIETIC CELL LINEAGE | 88 | 60 | All SZGR 2.0 genes in this pathway |
| BIOCARTA DC PATHWAY | 22 | 20 | All SZGR 2.0 genes in this pathway |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP | 177 | 110 | All SZGR 2.0 genes in this pathway |
| TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN | 187 | 115 | All SZGR 2.0 genes in this pathway |
| KLEIN TARGETS OF BCR ABL1 FUSION | 45 | 34 | All SZGR 2.0 genes in this pathway |
| DAIRKEE TERT TARGETS UP | 380 | 213 | All SZGR 2.0 genes in this pathway |
| GOLUB ALL VS AML DN | 24 | 14 | All SZGR 2.0 genes in this pathway |
| BROWN MYELOID CELL DEVELOPMENT UP | 165 | 100 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | All SZGR 2.0 genes in this pathway |
| LABBE WNT3A TARGETS DN | 97 | 53 | All SZGR 2.0 genes in this pathway |
| FONTAINE PAPILLARY THYROID CARCINOMA DN | 80 | 53 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |