Gene Page: KLK4
Summary ?
| GeneID | 9622 |
| Symbol | KLK4 |
| Synonyms | AI2A1|ARM1|EMSP|EMSP1|KLK-L1|PRSS17|PSTS|kallikrein |
| Description | kallikrein related peptidase 4 |
| Reference | MIM:603767|HGNC:HGNC:6365|Ensembl:ENSG00000167749|HPRD:04793|Vega:OTTHUMG00000182964 |
| Gene type | protein-coding |
| Map location | 19q13.41 |
| Pascal p-value | 0.046 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| GFOD1 | 0.88 | 0.88 |
| TGOLN2 | 0.88 | 0.88 |
| PLEKHM3 | 0.87 | 0.87 |
| TRAPPC10 | 0.87 | 0.90 |
| PHLPP2 | 0.87 | 0.88 |
| CELSR2 | 0.87 | 0.89 |
| HTT | 0.87 | 0.87 |
| SIK2 | 0.86 | 0.88 |
| DNAJC16 | 0.86 | 0.87 |
| SH3PXD2A | 0.86 | 0.85 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| GNG11 | -0.53 | -0.58 |
| C1orf54 | -0.53 | -0.59 |
| AF347015.21 | -0.52 | -0.53 |
| SYCP3 | -0.52 | -0.59 |
| DBI | -0.51 | -0.58 |
| C1orf61 | -0.51 | -0.57 |
| RHOC | -0.50 | -0.55 |
| AL050337.1 | -0.49 | -0.57 |
| IL32 | -0.48 | -0.55 |
| VAMP5 | -0.47 | -0.45 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004252 | serine-type endopeptidase activity | IEA | glutamate (GO term level: 7) | - |
| GO:0003824 | catalytic activity | IEA | - | |
| GO:0008270 | zinc ion binding | IEA | - | |
| GO:0008233 | peptidase activity | IEA | - | |
| GO:0046872 | metal ion binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006508 | proteolysis | IEA | - | |
| GO:0006508 | proteolysis | NAS | 10438493 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005576 | extracellular region | TAS | 10077646 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID UPA UPAR PATHWAY | 42 | 30 | All SZGR 2.0 genes in this pathway |
| MOHANKUMAR TLX1 TARGETS UP | 414 | 287 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| NELSON RESPONSE TO ANDROGEN UP | 86 | 61 | All SZGR 2.0 genes in this pathway |