Gene Page: FRMPD4
Summary ?
| GeneID | 9758 |
| Symbol | FRMPD4 |
| Synonyms | PDZD10|PDZK10 |
| Description | FERM and PDZ domain containing 4 |
| Reference | MIM:300838|HGNC:HGNC:29007|Ensembl:ENSG00000169933|HPRD:10011|Vega:OTTHUMG00000021138 |
| Gene type | protein-coding |
| Map location | Xp22.2 |
| Fetal beta | -1.33 |
| eGene | Myers' cis & trans |
| Support | CompositeSet Darnell FMRP targets Potential synaptic genes |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4078312 | chr1 | 29815644 | FRMPD4 | 9758 | 0.08 | trans | ||
| rs16897381 | chr8 | 123771005 | FRMPD4 | 9758 | 0.17 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ERBB2 | 0.90 | 0.79 |
| MMP14 | 0.88 | 0.84 |
| EPHB4 | 0.86 | 0.77 |
| FSTL1 | 0.86 | 0.77 |
| PDPN | 0.86 | 0.72 |
| SLC2A10 | 0.85 | 0.76 |
| IQGAP2 | 0.84 | 0.70 |
| EEPD1 | 0.84 | 0.82 |
| PLCE1 | 0.83 | 0.69 |
| CHST14 | 0.83 | 0.71 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C5orf53 | -0.41 | -0.44 |
| AF347015.31 | -0.38 | -0.45 |
| MYL3 | -0.37 | -0.41 |
| MT-CO2 | -0.37 | -0.45 |
| MT1G | -0.37 | -0.46 |
| AF347015.27 | -0.36 | -0.44 |
| AF347015.33 | -0.36 | -0.42 |
| AF347015.21 | -0.36 | -0.49 |
| FXYD1 | -0.35 | -0.36 |
| S100B | -0.35 | -0.36 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| BENPORATH PRC2 TARGETS | 652 | 441 | All SZGR 2.0 genes in this pathway |
| SHIPP DLBCL CURED VS FATAL DN | 45 | 30 | All SZGR 2.0 genes in this pathway |
| LU AGING BRAIN DN | 153 | 120 | All SZGR 2.0 genes in this pathway |
| SU SALIVARY GLAND | 16 | 9 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER WITH H3K27ME3 DN | 228 | 114 | All SZGR 2.0 genes in this pathway |
| MUELLER COMMON TARGETS OF AML FUSIONS DN | 31 | 21 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 1HR DN | 222 | 147 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |