Gene Page: PSMD6
Summary ?
| GeneID | 9861 |
| Symbol | PSMD6 |
| Synonyms | Rpn7|S10|SGA-113M|p42A|p44S10 |
| Description | proteasome 26S subunit, non-ATPase 6 |
| Reference | HGNC:HGNC:9564|Ensembl:ENSG00000163636|HPRD:18370|Vega:OTTHUMG00000158765 |
| Gene type | protein-coding |
| Map location | 3p14.1 |
| Pascal p-value | 2.443E-5 |
| Sherlock p-value | 0.377 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0232 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| OAZ1 | 0.94 | 0.90 |
| FDX1L | 0.90 | 0.92 |
| TPI1 | 0.89 | 0.92 |
| UROD | 0.89 | 0.88 |
| TUSC2 | 0.88 | 0.87 |
| KLHDC3 | 0.88 | 0.88 |
| COX4I1 | 0.87 | 0.82 |
| PARD6A | 0.87 | 0.88 |
| TMEM205 | 0.86 | 0.85 |
| MECR | 0.86 | 0.88 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| EIF5B | -0.59 | -0.72 |
| THOC2 | -0.55 | -0.57 |
| ZNF326 | -0.54 | -0.54 |
| SFRS12 | -0.52 | -0.52 |
| MAP4K4 | -0.52 | -0.52 |
| RBM25 | -0.51 | -0.53 |
| UPF3B | -0.50 | -0.56 |
| AC005035.1 | -0.49 | -0.50 |
| ZC3H13 | -0.47 | -0.40 |
| AC005921.3 | -0.47 | -0.75 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17353931 | |
| GO:0016887 | ATPase activity | NAS | 10723133 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006510 | ATP-dependent proteolysis | NAS | 10723133 | |
| GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | EXP | 11285280 | |
| GO:0051436 | negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle | EXP | 15029244 | |
| GO:0051437 | positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle | EXP | 12791267 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0000502 | proteasome complex | NAS | 10723133 | |
| GO:0005829 | cytosol | IEA | - | |
| GO:0043234 | protein complex | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| PAAF1 | FLJ11848 | PAAF | Rpn14 | WDR71 | proteasomal ATPase-associated factor 1 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMA2 | HC3 | MU | PMSA2 | PSC2 | proteasome (prosome, macropain) subunit, alpha type, 2 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMB5 | LMPX | MB1 | MGC104214 | X | proteasome (prosome, macropain) subunit, beta type, 5 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMC1 | MGC24583 | MGC8541 | P26S4 | S4 | p56 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMC2 | MGC3004 | MSS1 | Nbla10058 | S7 | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMC3 | MGC8487 | TBP1 | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMC4 | MGC13687 | MGC23214 | MGC8570 | MIP224 | S6 | TBP7 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMC5 | S8 | SUG1 | TBP10 | TRIP1 | p45 | p45/SUG | proteasome (prosome, macropain) 26S subunit, ATPase, 5 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMC6 | CADP44 | MGC12520 | P44 | SUG2 | p42 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD1 | MGC133040 | MGC133041 | P112 | Rpn2 | S1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD10 | dJ889N15.2 | p28 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD11 | MGC3844 | Rpn6 | S9 | p44.5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD12 | MGC75406 | Rpn5 | p55 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD13 | HSPC027 | Rpn9 | S11 | p40.5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD14 | PAD1 | POH1 | rpn11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD2 | MGC14274 | P97 | Rpn1 | S2 | TRAP2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD3 | P58 | RPN3 | S3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD4 | AF | AF-1 | ASF | MCB1 | Rpn10 | S5A | pUB-R5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD7 | MOV34 | P40 | Rpn8 | S12 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMD8 | HIP6 | HYPF | MGC1660 | Nin1p | Rpn12 | S14 | p31 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | Affinity Capture-MS | BioGRID | 17353931 |
| TELO2 | CLK2 | DKFZp434A073 | FLJ10924 | KIAA0683 | TEL2 | c305C8.3 | hCLK2 | TEL2, telomere maintenance 2, homolog (S. cerevisiae) | Affinity Capture-MS | BioGRID | 17353931 |
| UBE3C | KIAA0010 | KIAA10 | ubiquitin protein ligase E3C | Affinity Capture-Western | BioGRID | 12692129 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PROTEASOME | 48 | 28 | All SZGR 2.0 genes in this pathway |
| BIOCARTA PROTEASOME PATHWAY | 28 | 19 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY WNT | 65 | 41 | All SZGR 2.0 genes in this pathway |
| REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | 48 | 29 | All SZGR 2.0 genes in this pathway |
| REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | 76 | 48 | All SZGR 2.0 genes in this pathway |
| REACTOME ER PHAGOSOME PATHWAY | 61 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CYCLE | 421 | 253 | All SZGR 2.0 genes in this pathway |
| REACTOME ORC1 REMOVAL FROM CHROMATIN | 67 | 37 | All SZGR 2.0 genes in this pathway |
| REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | 97 | 66 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | 64 | 43 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY THE B CELL RECEPTOR BCR | 126 | 90 | All SZGR 2.0 genes in this pathway |
| REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | 51 | 31 | All SZGR 2.0 genes in this pathway |
| REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | 48 | 27 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | 200 | 136 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | 49 | 33 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF APOPTOSIS | 58 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CYCLE MITOTIC | 325 | 185 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CYCLE CHECKPOINTS | 124 | 70 | All SZGR 2.0 genes in this pathway |
| REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | 65 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE | 57 | 35 | All SZGR 2.0 genes in this pathway |
| REACTOME M G1 TRANSITION | 81 | 45 | All SZGR 2.0 genes in this pathway |
| REACTOME G1 S TRANSITION | 112 | 63 | All SZGR 2.0 genes in this pathway |
| REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | 56 | 31 | All SZGR 2.0 genes in this pathway |
| REACTOME SYNTHESIS OF DNA | 92 | 53 | All SZGR 2.0 genes in this pathway |
| REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | 51 | 30 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF MRNA | 284 | 128 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF RNA | 330 | 155 | All SZGR 2.0 genes in this pathway |
| REACTOME MITOTIC G1 G1 S PHASES | 137 | 79 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF MITOTIC CELL CYCLE | 85 | 46 | All SZGR 2.0 genes in this pathway |
| REACTOME MITOTIC M M G1 PHASES | 172 | 98 | All SZGR 2.0 genes in this pathway |
| REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX | 65 | 36 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | 84 | 50 | All SZGR 2.0 genes in this pathway |
| REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | 53 | 31 | All SZGR 2.0 genes in this pathway |
| REACTOME DNA REPLICATION | 192 | 110 | All SZGR 2.0 genes in this pathway |
| REACTOME APOPTOSIS | 148 | 94 | All SZGR 2.0 genes in this pathway |
| REACTOME HIV INFECTION | 207 | 122 | All SZGR 2.0 genes in this pathway |
| REACTOME HOST INTERACTIONS OF HIV FACTORS | 132 | 81 | All SZGR 2.0 genes in this pathway |
| REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | 72 | 38 | All SZGR 2.0 genes in this pathway |
| REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | 73 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | 64 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | 51 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME ADAPTIVE IMMUNE SYSTEM | 539 | 350 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | 251 | 156 | All SZGR 2.0 genes in this pathway |
| REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | 212 | 129 | All SZGR 2.0 genes in this pathway |
| REACTOME S PHASE | 109 | 66 | All SZGR 2.0 genes in this pathway |
| REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | 56 | 34 | All SZGR 2.0 genes in this pathway |
| REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | 52 | 30 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE DN | 712 | 443 | All SZGR 2.0 genes in this pathway |
| MOHANKUMAR TLX1 TARGETS UP | 414 | 287 | All SZGR 2.0 genes in this pathway |
| GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | All SZGR 2.0 genes in this pathway |
| ROSS AML OF FAB M7 TYPE | 68 | 44 | All SZGR 2.0 genes in this pathway |
| PENG GLUTAMINE DEPRIVATION DN | 337 | 230 | All SZGR 2.0 genes in this pathway |
| FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK UP | 63 | 48 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| PAL PRMT5 TARGETS UP | 203 | 135 | All SZGR 2.0 genes in this pathway |
| ZHU CMV ALL UP | 120 | 89 | All SZGR 2.0 genes in this pathway |
| SESTO RESPONSE TO UV C0 | 107 | 72 | All SZGR 2.0 genes in this pathway |
| ZHU CMV 24 HR UP | 93 | 65 | All SZGR 2.0 genes in this pathway |
| JIANG HYPOXIA NORMAL | 311 | 205 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 | 482 | 296 | All SZGR 2.0 genes in this pathway |
| PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP | 64 | 40 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS UP | 518 | 299 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14 | 143 | 86 | All SZGR 2.0 genes in this pathway |
| LU EZH2 TARGETS DN | 414 | 237 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |