Gene Page: NRG3

Summary ?
GeneID10718
SymbolNRG3
SynonymsHRG3|pro-NRG3
Descriptionneuregulin 3
ReferenceMIM:605533|HGNC:HGNC:7999|Ensembl:ENSG00000185737|HPRD:16115|Vega:OTTHUMG00000018626
Gene typeprotein-coding
Map location10q23.1
Pascal p-value0.009
Fetal beta-0.328
DMG1 (# studies)
SupportNEUROTROPHIN SIGNALING

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg045293701083635300NRG34.22E-10-0.0167.8E-7DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008083growth factor activityNAS9275162 
GO:0030971receptor tyrosine kinase bindingNAS9275162 
GO:0030297transmembrane receptor protein tyrosine kinase activator activityNAS9275162 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001558regulation of cell growthNAS9275162 
GO:0007243protein kinase cascadeIEA-
GO:0009790embryonic developmentIEA-
GO:0030879mammary gland developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS9275162 
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneNAS9275162 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ERBB SIGNALING PATHWAY 8771All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY 3631All SZGR 2.0 genes in this pathway
PID ERBB4 PATHWAY 3832All SZGR 2.0 genes in this pathway
PID ERBB NETWORK PATHWAY 1513All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP 214133All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA MF DN 4128All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway