Gene Page: MMP2

Summary
GeneID  4313
Symbol  MMP2
Synonyms  CLG4|CLG4A|MMP-II|MONA|TBE-1
Description  matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
See related  HGNC:7166|MIM:120360|Ensembl:ENSG00000087245|HPRD:00386|
Locus tag  -
Gene type  protein-coding
Map location  16q13-q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.4072 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI15146192 
GO:0004222metalloendopeptidase activityIEA-
GO:0004222metalloendopeptidase activityTAS2834383 
GO:0008270zinc ion bindingTAS2834383 
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001955blood vessel maturationIEA-
GO:0006508proteolysisTAS2834383 
GO:0008152metabolic processIEA-
GO:0030574collagen catabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005578proteinaceous extracellular matrixIEA-
GO:0005615extracellular spaceTAS2834383 
GO:0030017sarcomereIEA-
GO:0005886plasma membraneIEA-
GO:0043231intracellular membrane-bounded organelleIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
A2MCPAMD5 | DKFZp779B086 | FWP007 | S863-7alpha-2-macroglobulinReconstituted ComplexBioGRID9344465 
BACE1ASP2 | BACE | FLJ90568 | HSPC104 | KIAA1149beta-site APP-cleaving enzyme 1-HPRD12586836 
BCANBEHAB | CSPG7 | MGC13038brevican-HPRD,BioGRID10986281 
CCL7FIC | MARC | MCP-3 | MCP3 | MGC138463 | MGC138465 | NC28 | SCYA6 | SCYA7chemokine (C-C motif) ligand 7-HPRD,BioGRID10947989 |12149192 
CLDN1CLD1 | ILVASC | SEMP1claudin 1-HPRD11382769 
COL18A1FLJ27325 | FLJ34914 | KNO | KNO1 | MGC74745collagen, type XVIII, alpha 1-HPRD,BioGRID12023034 
COL1A1OI4collagen, type I, alpha 1-HPRD,BioGRID11368514 
COL6A3DKFZp686D23123 | DKFZp686K04147 | DKFZp686N0262 | FLJ34702 | FLJ98399collagen, type VI, alpha 3-HPRD8862926 
COL7A1EBD1 | EBDCT | EBR1collagen, type VII, alpha 1-HPRD10652000 
CXCL12PBSF | SCYB12 | SDF-1a | SDF-1b | SDF1 | SDF1A | SDF1B | TLSF-a | TLSF-b | TPAR1chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)-HPRD,BioGRID11571304 
ITGAVCD51 | DKFZp686A08142 | MSK8 | VNRAintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)-HPRD,BioGRID11134507 
LCN2NGALlipocalin 2-HPRD,BioGRID7683678 
MMP17MT4-MMPmatrix metallopeptidase 17 (membrane-inserted)-HPRD,BioGRID10551873 
PZPCPAMD6 | MGC133093pregnancy-zone proteinReconstituted ComplexBioGRID9344465 
SPOCK1FLJ37170 | SPOCK | TESTICAN | TIC1sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1-HPRD12810672 
TGFB1CED | DPD1 | TGFB | TGFbetatransforming growth factor, beta 1-HPRD,BioGRID10652271 
THBS1THBS | TSP | TSP1thrombospondin 1-HPRD,BioGRID10900205 
THBS2TSP2thrombospondin 2-HPRD,BioGRID10900205 
TIMP2CSC-21KTIMP metallopeptidase inhibitor 2-HPRD,BioGRID9933646 |10991943 
|12032297 |12374789 
TIMP3HSMRK222 | K222 | K222TA2 | SFDTIMP metallopeptidase inhibitor 3-HPRD,BioGRID10196161 
TIMP4-TIMP metallopeptidase inhibitor 4-HPRD,BioGRID9182583 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 11878All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_BLADDER_CANCER 4233All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY 6653All SZGR genes in this pathway
PID_ER_NONGENOMIC_PATHWAY 4135All SZGR genes in this pathway
PID_AVB3_OPN_PATHWAY 3129All SZGR genes in this pathway
PID_FRA_PATHWAY 3728All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_AMB2_NEUTROPHILS_PATHWAY 4132All SZGR genes in this pathway
PID_ATF2_PATHWAY 5943All SZGR genes in this pathway
PID_FOXM1_PATHWAY 4030All SZGR genes in this pathway
PID_BETA_CATENIN_NUC_PATHWAY 8060All SZGR genes in this pathway
PID_SYNDECAN_2_PATHWAY 3327All SZGR genes in this pathway
REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX 2911All SZGR genes in this pathway
REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION 8742All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS 1612All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP 285181All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_UP 183119All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_DN 182111All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_DN 7442All SZGR genes in this pathway
WILCOX_RESPONSE_TO_PROGESTERONE_DN 6644All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_DN 242165All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN 281186All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_DN 187115All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
BARIS_THYROID_CANCER_DN 5945All SZGR genes in this pathway
ROYLANCE_BREAST_CANCER_16Q_COPY_NUMBER_DN 2619All SZGR genes in this pathway
OUELLET_CULTURED_OVARIAN_CANCER_INVASIVE_VS_LMP_DN 3520All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP 169127All SZGR genes in this pathway
MAHADEVAN_GIST_MORPHOLOGICAL_SWITCH 1511All SZGR genes in this pathway
BAKER_HEMATOPOESIS_STAT1_TARGETS 109All SZGR genes in this pathway
BAKER_HEMATOPOIESIS_STAT3_TARGETS 1612All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
AGARWAL_AKT_PATHWAY_TARGETS 109All SZGR genes in this pathway
YAN_ESCAPE_FROM_ANOIKIS 2419All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
KARAKAS_TGFB1_SIGNALING 1815All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
KENNY_CTNNB1_TARGETS_UP 5030All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_UP 197110All SZGR genes in this pathway
ROSS_AML_WITH_PML_RARA_FUSION 7762All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP 7151All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_UP 205126All SZGR genes in this pathway
SMITH_TERT_TARGETS_DN 8769All SZGR genes in this pathway
MANALO_HYPOXIA_UP 207145All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_UP 14083All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_UP 183111All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_6HR 5938All SZGR genes in this pathway
DELASERNA_MYOD_TARGETS_DN 5742All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_12HR 3523All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_DN 5233All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
WESTON_VEGFA_TARGETS 10871All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C5 2111All SZGR genes in this pathway
VERRECCHIA_DELAYED_RESPONSE_TO_TGFB1 3926All SZGR genes in this pathway
LIU_SMARCA4_TARGETS 6439All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
JI_CARCINOGENESIS_BY_KRAS_AND_STK11_DN 1712All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
YAGUE_PRETUMOR_DRUG_RESISTANCE_DN 1311All SZGR genes in this pathway
QI_PLASMACYTOMA_DN 10063All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
ALONSO_METASTASIS_EMT_UP 3624All SZGR genes in this pathway
ALONSO_METASTASIS_UP 198128All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
JU_AGING_TERC_TARGETS_UP 106All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K27ME3 269159All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
VALK_AML_WITH_FLT3_ITD 4022All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_2 8650All SZGR genes in this pathway
NIELSEN_LEIOMYOSARCOMA_CNN1_DN 2018All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_DN 11683All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_UP 13485All SZGR genes in this pathway
KANG_AR_TARGETS_UP 1710All SZGR genes in this pathway
STEGER_ADIPOGENESIS_DN 2515All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_UP 169105All SZGR genes in this pathway
KOHOUTEK_CCNT2_TARGETS 5835All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
DELACROIX_RAR_TARGETS_UP 4833All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_UP 266142All SZGR genes in this pathway
ANASTASSIOU_CANCER_MESENCHYMAL_TRANSITION_SIGNATURE 6440All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-29299305m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-324-3p415421m8hsa-miR-324-3pCCACUGCCCCAGGUGCUGCUGG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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