Gene Page: SLIT2

Summary
GeneID  9353
Symbol  SLIT2
Synonyms  FLJ14420|SLIL3|Slit-2
Description  slit homolog 2 (Drosophila)
See related  HGNC:11086|MIM:603746|Ensembl:ENSG00000145147|HPRD:04776|
Locus tag  -
Gene type  protein-coding
Map location  4p15.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 7 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TPX20.990.88
BUB1B0.990.83
BUB10.990.80
MELK0.980.81
PRC10.980.81
KIF150.980.80
CDCA20.980.77
EXO10.980.79
CEP550.980.80
MCM100.980.80
Top 10 negatively co-expressed genes
HLA-F-0.38-0.72
FBXO2-0.38-0.60
PTH1R-0.38-0.65
C5orf53-0.38-0.65
SLC9A3R2-0.38-0.41
AF347015.27-0.37-0.80
AIFM3-0.37-0.68
AF347015.31-0.37-0.80
TNFSF12-0.37-0.61
ALDOC-0.37-0.65
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingTASNeurotransmitter (GO term level: 4)10102268 
GO:0005509calcium ion bindingIEA-
GO:0004963follicle-stimulating hormone receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0031290retinal ganglion cell axon guidanceIEAaxon, Brain (GO term level: 14)-
GO:0008045motor axon guidanceTASneuron, axon (GO term level: 14)10102268 
GO:0008038neuron recognitionTASneuron (GO term level: 4)10432110 
GO:0008347glial cell migrationIMPneuron, Glial (GO term level: 8)10102268 
GO:0050772positive regulation of axonogenesisTASaxon, neurogenesis (GO term level: 14)10197527 
GO:0007399nervous system developmentTASneurite (GO term level: 5)9813312 
GO:0001657ureteric bud developmentIMP15130495 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007509mesoderm migrationIMP10102268 
GO:0007608sensory perception of smellTAS10102269 
GO:0006935chemotaxisIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0050929induction of negative chemotaxisIDA10197527 
GO:0050929induction of negative chemotaxisIMP10102268 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIDA10102268 
GO:0005615extracellular spaceIEA-
GO:0016021integral to membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GPC1FLJ38078 | glypicanglypican 1-HPRD,BioGRID10364234 |11375980 
ROBO1DUTT1 | FLJ21882 | MGC131599 | MGC133277 | SAX3roundabout, axon guidance receptor, homolog 1 (Drosophila)-HPRD,BioGRID10102268 
ROBO2KIAA1568 | SAX3roundabout, axon guidance receptor, homolog 2 (Drosophila)-HPRD,BioGRID10102268 
ROBO4FLJ20798 | MGC133352 | MGC133353 | MRBroundabout homolog 4, magic roundabout (Drosophila)Affinity Capture-WesternBioGRID12941633 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
PID_GLYPICAN_1PATHWAY 2720All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_RAC 1411All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ROBO_RECEPTOR 3026All SZGR genes in this pathway
REACTOME_NETRIN1_SIGNALING 4130All SZGR genes in this pathway
CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN 391222All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_UP 13378All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_UP 175120All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_DN 11879All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN 199124All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_DN 6743All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_DN 7752All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_UP 6045All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
PEREZ_TP53_AND_TP63_TARGETS 205145All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_DN 8871All SZGR genes in this pathway
SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP 7347All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
HATADA_METHYLATED_IN_LUNG_CANCER_UP 390236All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
SCHAEFFER_SOX9_TARGETS_IN_PROSTATE_DEVELOPMENT_DN 4533All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
FRASOR_RESPONSE_TO_ESTRADIOL_DN 8252All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_DN 8662All SZGR genes in this pathway
DELASERNA_MYOD_TARGETS_DN 5742All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
GENTILE_UV_LOW_DOSE_DN 6746All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
AMBROSINI_FLAVOPIRIDOL_TREATMENT_TP53 10963All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP 10575All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING 243155All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_1_DN 6339All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D 280158All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
PLASARI_NFIC_TARGETS_BASAL_DN 1813All SZGR genes in this pathway
WANG_MLL_TARGETS 289188All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
NABA_ECM_GLYCOPROTEINS 19699All SZGR genes in this pathway
NABA_CORE_MATRISOME 275148All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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