Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase

Found 28 literature records

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Entrez IDDescription
51364BLU may be one of the critical tumor suppressor genes on chromosome 3p21.3 involved in the development of nasopharyngeal carcinoma
11186RASSF1A is a target tumor suppressor from 3p21.3 in nasopharyngeal carcinoma
51364"BLU, a candidate tumor suppressor gene, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma."
10912Results show that GADD45G can act as a functional new-age tumor suppressor but being frequently inactivated epigenetically in multiple tumors.
57575"Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation."
10395DLC1 appears to be a major tumor suppressor genes implicated in the pathogenesis of these tumors
23705"TSLC1 inhibits nasopharyngeal carcinoma cell growth by arresting cells in G(0)-G(1) phase in normal culture conditions. Without serum, TSLC1 induced apoptosis. TSLC1 is a tumor suppressor gene in NPC; its loss is seen in lymphatic metastasis."
56999These findings support ADAMTS9 as a putative tumor suppressor gene in vivo in NPC that is significantly associated with lymph node metastases.
139285Tumor suppressor WTX gene mutation is rare in acute leukemias.
3394"IRF8 was identified as a functional tumor suppressor, which is frequently silenced by epigenetic mechanism in multiple carcinomas"
4057Lactotransferrin is likely to be a candidate tumor suppressor and downregulates the development of nasopharyngeal carcinoma (NPC) by inhibiting NPC proliferation through induction of cell cycle arrest and modulation of the MAPK signaling pathway.
4978"OPCML is a broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies."
401317"Collectively, these results suggest that LOC401317 is directly regulated by p53 and exerts antitumor effects in HNE2 nasopharyngeal carcinoma cells."
4013Tumor suppressor function of BCSC-1 in nasopharyngeal carcinoma.
4013increased E-cadherin and alpha-catenin expression and reduced Wnt signaling might be involved in the mechanisms of tumor suppressor function of BCSC-1.
5728The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells.
7070Functional characterization of THY1 as a tumor suppressor gene with antiinvasive activity in nasopharyngeal carcinoma.
56999"The ADAMTS9 gene (ADAM metallopeptidase with thrombospondin type 1 motif, 9); has been characterized as a novel tumor suppressor gene in and epigenetically silenced in association with lymph node metastases in nasopharyngeal carcinoma."
7980TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma.
1848Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype.
1002CDH4 as a novel putative tumor suppressor gene epigenetically silenced by promoter hypermethylation in nasopharyngeal carcinoma.
406929"The miR-138 might be a tumor suppressor in nasopharyngeal carcinoma, which is exerted partially by inhibiting CCND1 expression."
4057Lactotransferrin acts as a tumor suppressor in nasopharyngeal carcinoma by repressing AKT through multiple mechanisms.
127700"Data revealed novel aspects of the interplay between autophagy and apoptosis in nasopharyngeal carcinoma cells, which underlies the tumor suppression function of NOR1."
27250PDCD4 as tumor suppressor regulated miR-184-mediated direct targeting of BCL2 and C-MYC.
51700"findings suggest that CYB5R2 may be a functional tumor suppressor gene, frequently inactivated by hypermethylation of its promoter in nasopharyngeal carcinoma"
6288"homozygous SAA1.5/1.5 genotype appears to be a recessive susceptibility gene, which has lost the antiangiogenic function, whereas SAA1.1 and SAA1.3 are the dominant alleles of the tumor suppressor phenotype."
2272Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines.

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