DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_SCF_FBW7_1

Location: 1057:1063

E3 ligase: FBXW7

DEGRON score: 0.6082

ASA_SCORE: 89.1571

COIL: 0.9554

CONS_SCORE: 0.2079

DSS_SCORE: 0.743

HELIX: 0.0159

FCONS_SCORE: 0.661

RIG_SCORE: 0.5947

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1067R	DO10662	COAD	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1071L	DO227499	LAML	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.1111
p.T1059P	DO227499	LAML	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.7031
p.L1064P	DO224584	LUSC	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.3056
p.L1064P	DO227544	PACA	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.3056
p.L1064P	DO230499	PRAD	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.3056
p.L1064P	DO230590	PRAD	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.3056
p.L1064P	DO230512	PRAD	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.3056
p.L1064P	DO51086	PRAD	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.3056
p.P1060L	DO220886	MELA	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.7582
p.P1053S	DO222494	MELA	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1053S	ACH-000304	Skin Cancer	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1053S	ACH-001239	Skin Cancer	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1053S	WM-115	skin	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1047S	DO218900	SKCA	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.0556
p.P1065S	DO51257	SKCM	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.T1058R	ACH-000281	Pancreatic Cancer	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.6765
p.T1058R	KP-2	pancreas	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.6765
p.P1060S	ACH-000925	Lung Cancer	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.6752
p.P1065L	ACH-001127	Leukemia	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1065L	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1057:1063	PTTPAAT	FBXW7	0.6082	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1126:1132	PTTPAAT	FBXW7	0.9606	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1149:1155	PTTPAAT	FBXW7	0.697	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1172:1178	PTTPAAT	FBXW7	0.7635	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1195:1201	PTTPAAT	FBXW7	0.7319	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1218:1224	PTTPAAT	FBXW7	0.7848	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1241:1247	PTTPAAT	FBXW7	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons