DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_SCF_FBW7_1

Location: 1241:1247

E3 ligase: FBXW7

DEGRON score: 0.9657

ASA_SCORE: 93.4857

COIL: 0.9697

CONS_SCORE: 0.4094

DSS_SCORE: 0.789

HELIX: 0.01

FCONS_SCORE: 1.2854

RIG_SCORE: 0.5195

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1246T	DO44441	HNSC	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.6028
p.P1237S	DO222708	MELA	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.S1236P	DO227544	PACA	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.1944
p.S1236P	ACH-000186	Lung Cancer	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.1944
p.S1236P	NCI-H2444	lung	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.1944
p.P1244L	DO37827	SKCM	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.7582
p.A1246V	ACH-000920	Leukemia	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.5825
p.A1245T	ACH-000995	Leukemia	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.6028
p.P1237T	ACH-001127	Leukemia	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1237T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1255L	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.1111
p.P1255L	NCI-H2444	lung	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.1111
p.P1255L	NCI-H835	lung	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.1111
p.P1244Q	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.7035
p.P1244T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1057:1063	PTTPAAT	FBXW7	0.6082	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1126:1132	PTTPAAT	FBXW7	0.9606	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1149:1155	PTTPAAT	FBXW7	0.697	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1172:1178	PTTPAAT	FBXW7	0.7635	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1195:1201	PTTPAAT	FBXW7	0.7319	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1218:1224	PTTPAAT	FBXW7	0.7848	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1241:1247	PTTPAAT	FBXW7	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons