DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_SCF_FBW7_1

Location: 1195:1201

E3 ligase: FBXW7

DEGRON score: 0.7319

ASA_SCORE: 92.4143

COIL: 0.9686

CONS_SCORE: 0.2706

DSS_SCORE: 0.7738

HELIX: 0.0109

FCONS_SCORE: 0.9176

RIG_SCORE: 0.5495

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1191S	DO15623	HNSC	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1191L	DO15623	HNSC	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1191L	DO26444	LUSC	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.L1209P	DO228815	LICA	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.1111
p.T1197P	DO224576	LUSC	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.7031
p.S1190P	DO218854	SKCA	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.1944
p.T1211A	DO48044	STAD	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1057:1063	PTTPAAT	FBXW7	0.6082	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1126:1132	PTTPAAT	FBXW7	0.9606	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1149:1155	PTTPAAT	FBXW7	0.697	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1172:1178	PTTPAAT	FBXW7	0.7635	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1195:1201	PTTPAAT	FBXW7	0.7319	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1218:1224	PTTPAAT	FBXW7	0.7848	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1241:1247	PTTPAAT	FBXW7	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons