DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_SCF_FBW7_1

Location: 1218:1224

E3 ligase: FBXW7

DEGRON score: 0.7848

ASA_SCORE: 93.3714

COIL: 0.9693

CONS_SCORE: 0.3378

DSS_SCORE: 0.7756

HELIX: 0.0106

FCONS_SCORE: 0.9958

RIG_SCORE: 0.5495

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1209P	DO228815	LICA	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.0833
p.T1220I	DO46657	PAAD	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.7078
p.T1220P	DO46771	PAEN	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.7031
p.S1213P	DO218878	SKCA	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.1944
p.S1213P	SJSA-1	bone	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.1944
p.S1213P	A2780	ovary	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.1944
p.S1213P	NB5	autonomic_ganglia	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.1944
p.S1213P	SNU-C1	large_intestine	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.1944
p.S1213P	LC-1-sq	lung	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.1944
p.S1213P	SCaBER	urinary_tract	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.1944
p.S1213P	NCI-H835	lung	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.1944
p.P1214S	DO37437	SKCM	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1214S	DO47636	SKCM	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.S1227F	DO37931	SKCM	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.25
p.T1211A	DO48044	STAD	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.1389
p.P1226L	ACH-000151	Leukemia	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1226L	JM1	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1225L	ACH-000464	Brain Cancer	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.3056
p.P1225L	CAS-1	central_nervous_system	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.3056
p.P1214H	NCI-H835	lung	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1214H	LC-1-sq	lung	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1214H	SCaBER	urinary_tract	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1214H	SJSA-1	bone	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1214H	A2780	ovary	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1214H	SNU-C1	large_intestine	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1057:1063	PTTPAAT	FBXW7	0.6082	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1126:1132	PTTPAAT	FBXW7	0.9606	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1149:1155	PTTPAAT	FBXW7	0.697	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1172:1178	PTTPAAT	FBXW7	0.7635	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1195:1201	PTTPAAT	FBXW7	0.7319	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1218:1224	PTTPAAT	FBXW7	0.7848	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1241:1247	PTTPAAT	FBXW7	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons