DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_SCF_FBW7_1

Location: 1172:1178

E3 ligase: FBXW7

DEGRON score: 0.7635

ASA_SCORE: 92.3429

COIL: 0.9684

CONS_SCORE: 0.1898

DSS_SCORE: 0.7882

HELIX: 0.0107

FCONS_SCORE: 0.67

RIG_SCORE: 0.5493

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1180L	DO15623	HNSC	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.G1170R	DO22237	LGG	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.T1174P	DO51953	PRAD	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.7031
p.P1182S	DO37996	SKCM	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1175S	DO38123	SKCM	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.6752
p.P1167L	ACH-000918	Leukemia	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.1944
p.P1167L	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.1944
p.A1171V	ACH-000998	Colon/Colorectal Cancer	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.3056
p.A1171V	CW-2	large_intestine	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1057:1063	PTTPAAT	FBXW7	0.6082	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1126:1132	PTTPAAT	FBXW7	0.9606	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1149:1155	PTTPAAT	FBXW7	0.697	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1172:1178	PTTPAAT	FBXW7	0.7635	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1195:1201	PTTPAAT	FBXW7	0.7319	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1218:1224	PTTPAAT	FBXW7	0.7848	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1241:1247	PTTPAAT	FBXW7	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons