DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_SCF_FBW7_1

Location: 1126:1132

E3 ligase: FBXW7

DEGRON score: 0.9606

ASA_SCORE: 91.4571

COIL: 0.9699

CONS_SCORE: 0.2838

DSS_SCORE: 0.8047

HELIX: 0.0097

FCONS_SCORE: 0.9746

RIG_SCORE: 0.5377

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1122P	DO229016	COCA	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.H1122P	DO229003	COCA	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.H1122P	DO23306	LINC	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.H1122P	DO227544	PACA	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1129Q	DO50458	KIRC	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.7035
p.L1140P	DO227499	LAML	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.1111
p.H1122Q	DO23184	LINC	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.H1122Q	DO23306	LINC	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2222
p.P1134L	DO52365	LUSC	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1134L	DO37839	SKCM	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1134L	ACH-000362	Leukemia	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1134L	ACH-000974	Endometrial/Uterine Cancer	CCLE	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1134L	LK-2	lung	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1134L	KMH-2	thyroid	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1134L	RMG-I	ovary	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1134L	SNG-M	endometrium	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1134L	RERF-LC-MS	lung	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1134L	ECC12	stomach	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1134L	KS-1	central_nervous_system	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1134L	8305C	thyroid	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.P1134L	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPAAT	DEG_SCF_FBW7_1	0.2778
p.T1128P	DO231064	LUSC	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.7031
p.T1128P	DO218851	SKCA	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.7031
p.A1131V	DO27556	LUSC	ICGC	PTTPAAT	DEG_SCF_FBW7_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1057:1063	PTTPAAT	FBXW7	0.6082	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1126:1132	PTTPAAT	FBXW7	0.9606	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1149:1155	PTTPAAT	FBXW7	0.697	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1172:1178	PTTPAAT	FBXW7	0.7635	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1195:1201	PTTPAAT	FBXW7	0.7319	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1218:1224	PTTPAAT	FBXW7	0.7848	More...
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	1241:1247	PTTPAAT	FBXW7	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons